CB2 receptor
E278052
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
All labels observed (6)
| Label | Occurrences |
|---|---|
| CB2 receptor canonical | 5 |
| CB2R | 1 |
| CNR2 gene | 1 |
| cannabinoid receptor 2 | 1 |
| cannabinoid receptor 2 (macrophage) | 1 |
| cannabinoid receptor type 2 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2523399 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CB2 receptor Context triple: [THC, actsOnReceptor, CB2 receptor]
-
A.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
B.
rimonabant
Rimonabant is a selective cannabinoid CB1 receptor antagonist that was developed as an anti-obesity drug but withdrawn due to psychiatric side effects.
-
C.
endocannabinoid system
The endocannabinoid system is a widespread cell-signaling network in the body that helps regulate processes such as mood, appetite, pain, memory, and immune function through cannabinoid receptors, endogenous ligands, and metabolic enzymes.
-
D.
CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
-
E.
CBD
CBD is a non-intoxicating compound found in cannabis that is widely used for its potential therapeutic effects, such as reducing anxiety, pain, and inflammation.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CB2 receptor Target entity description: The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
A.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
B.
rimonabant
Rimonabant is a selective cannabinoid CB1 receptor antagonist that was developed as an anti-obesity drug but withdrawn due to psychiatric side effects.
-
C.
endocannabinoid system
The endocannabinoid system is a widespread cell-signaling network in the body that helps regulate processes such as mood, appetite, pain, memory, and immune function through cannabinoid receptors, endogenous ligands, and metabolic enzymes.
-
D.
CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
-
E.
CBD
CBD is an international treaty adopted in 1992 that aims to conserve biological diversity, promote sustainable use of its components, and ensure fair and equitable sharing of benefits arising from genetic resources.
- F. None of above. chosen
Statements (53)
| Predicate | Object |
|---|---|
| instanceOf |
G protein-coupled receptor
ⓘ
cannabinoid receptor ⓘ |
| activatedBy |
phytocannabinoids
ⓘ
synthetic cannabinoids ⓘ Δ9-tetrahydrocannabinol ⓘ |
| belongsToFamily | class A rhodopsin-like GPCRs ⓘ |
| couplesTo | Gi/o proteins ⓘ |
| encodedBy |
CNR2 gene
ⓘ
linked to:
CB2 receptor
|
| hasAlternativeName |
CB2R
ⓘ
linked to:
CB2 receptor
cannabinoid receptor 2 ⓘ
linked to:
CB2 receptor
cannabinoid receptor type 2 ⓘ
linked to:
CB2 receptor
|
| hasEndogenousLigand |
2-arachidonoylglycerol
ⓘ
anandamide ⓘ endocannabinoids ⓘ |
| hasLowExpressionIn | central nervous system ⓘ |
| hasMolecularFunction |
G protein-coupled receptor activity
ⓘ
cannabinoid receptor activity ⓘ |
| hasOrthologIn |
mouse Cnr2
ⓘ
rat Cnr2 ⓘ |
| hasTherapeuticPotentialIn |
autoimmune disorders
ⓘ
cancer ⓘ chronic pain ⓘ inflammatory diseases ⓘ neurodegenerative diseases ⓘ |
| hasTransmembraneDomains | 7 ⓘ |
| highlyExpressedIn |
B cells
ⓘ
macrophages ⓘ monocytes ⓘ natural killer cells ⓘ peripheral blood leukocytes ⓘ spleen ⓘ tonsils ⓘ |
| inhibits | adenylate cyclase ⓘ |
| involvedIn |
allergic inflammation
ⓘ
autoimmune disease mechanisms ⓘ bone remodeling ⓘ fibrosis ⓘ immunomodulation ⓘ neuroinflammation ⓘ pain modulation ⓘ |
| isDrugTargetFor |
analgesic agents
ⓘ
anti-fibrotic drugs ⓘ anti-inflammatory agents ⓘ anti-osteoporotic drugs ⓘ immunomodulatory drugs ⓘ |
| locatedIn | cell membrane ⓘ |
| modulates |
MAP kinase signaling pathways
ⓘ
cytokine release ⓘ immune responses ⓘ inflammatory responses ⓘ ion channel activity ⓘ |
| primarilyExpressedIn |
immune system
ⓘ
peripheral tissues ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CB2 receptor Description of subject: The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
Referenced by (10)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: CB2 receptor
linked to: CB2 receptor
linked to: CB2 receptor
linked to: CB2 receptor