THC

E55576

organic compound phytocannabinoid psychoactive drug terpenophenolic compound

THC (tetrahydrocannabinol) is the primary psychoactive compound in cannabis responsible for the plant’s mind-altering effects.

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All labels observed (3)

Label	Occurrences
THC canonical	7
delta-9-THC	1
Δ⁹-THC	1

How this entity was disambiguated

This entity first appeared as the object of triple T442798 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: THC
Context triple: [Cannabis, producesCompound, THC]

A. Cannabis
Cannabis is a genus of flowering plants best known for producing psychoactive and medicinal compounds such as THC and CBD, widely used for recreational, therapeutic, and industrial (hemp) purposes.
B. Canna
Canna is a small, historically rich island in Scotland’s Inner Hebrides, known for its wildlife, archaeological sites, and ownership by the National Trust for Scotland.
C. CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
D. Papaver somniferum
Papaver somniferum is the opium poppy, a flowering plant cultivated both for its edible seeds and for producing opiates such as morphine and codeine.
E. Cresco
Cresco is a small city in northeastern Iowa known for its agricultural community and historic architecture.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: THC
Target entity description: THC (tetrahydrocannabinol) is the primary psychoactive compound in cannabis responsible for the plant’s mind-altering effects.

A. Cannabis
Cannabis is a genus of flowering plants best known for producing psychoactive and medicinal compounds such as THC and CBD, widely used for recreational, therapeutic, and industrial (hemp) purposes.
B. Canna
Canna is a small, historically rich island in Scotland’s Inner Hebrides, known for its wildlife, archaeological sites, and ownership by the National Trust for Scotland.
C. CBG
CBG is the National Rail station code for Cambridge railway station in Cambridge, England.
D. Papaver somniferum
Papaver somniferum is the opium poppy, a flowering plant cultivated both for its edible seeds and for producing opiates such as morphine and codeine.
E. Cresco
Cresco is a small city in northeastern Iowa known for its agricultural community and historic architecture.
F. None of above. chosen

Statements (70)

Predicate	Object
instanceOf	organic compound ⓘ phytocannabinoid ⓘ psychoactive drug ⓘ terpenophenolic compound ⓘ
actsOnReceptor	CB1 receptor ⓘ CB2 receptor ⓘ
administrationRoute	inhalation ⓘ oral ⓘ sublingual ⓘ topical ⓘ
alsoKnownAs	delta-9-THC ⓘ linked to: THC delta-9-tetrahydrocannabinol ⓘ Δ⁹-THC ⓘ linked to: THC
biosynthesizedFrom	THCA (tetrahydrocannabinolic acid) ⓘ
boilingPoint	157 °C ⓘ
canCause	acute cognitive impairment ⓘ
chemicalFormula	C21H30O2 ⓘ
chemicalName	tetrahydrocannabinol ⓘ
conversionProcess	decarboxylation of THCA ⓘ
dependencePotential	can lead to cannabis use disorder in some users ⓘ
detectableIn	blood ⓘ hair ⓘ saliva ⓘ urine ⓘ
discoveredIn	20th century ⓘ
drugClass	cannabinoid receptor agonist ⓘ
durationInhalation	2–4 hours ⓘ
durationOral	4–8 hours ⓘ
excretionRoute	feces ⓘ urine ⓘ
foundIn	Cannabis indica ⓘ linked to: Cannabis Cannabis sativa ⓘ linked to: Cannabis
isolatedBy	Raphael Mechoulam ⓘ
IUPACName	(−)-trans-Δ⁹-tetrahydrocannabinol ⓘ
legalStatus	controlled substance in many countries ⓘ
legalUse	medical use in some jurisdictions ⓘ recreational use in some jurisdictions ⓘ
meltingPoint	66 °C ⓘ
metabolizedIn	liver ⓘ
molarMass	314.46 g/mol ⓘ
onsetInhalation	within minutes ⓘ
onsetOral	30–120 minutes ⓘ
origin	plant-derived ⓘ
potentialTherapeuticUse	analgesic ⓘ antiemetic ⓘ appetite stimulant ⓘ
primaryMetabolite	11-hydroxy-THC ⓘ
psychoactiveEffect	altered perception ⓘ altered time perception ⓘ euphoria ⓘ impairment of short-term memory ⓘ increased appetite ⓘ relaxation ⓘ
receptorSystem	endocannabinoid system ⓘ
relatedCompound	CBD (cannabidiol) ⓘ CBN (cannabinol) ⓘ
role	primary psychoactive constituent of cannabis ⓘ
scheduleUS	Schedule I controlled substance at federal level (except certain formulations) ⓘ
secondaryMetabolite	THC-COOH ⓘ
sideEffect	anxiety ⓘ dry mouth ⓘ impaired coordination ⓘ paranoia ⓘ red eyes ⓘ tachycardia ⓘ
solubility	insoluble in water ⓘ soluble in lipids ⓘ soluble in organic solvents ⓘ
usedIn	prescription medicine dronabinol (synthetic THC) ⓘ
yearIsolated	1964 ⓘ