rat Cnr2
E939679
Rat Cnr2 is the rat gene encoding the cannabinoid receptor type 2 (CB2), a G protein–coupled receptor involved in modulating immune and inflammatory responses.
All labels observed (1)
| Label | Occurrences |
|---|---|
| rat Cnr2 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11698308 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: rat Cnr2 Context triple: [CB2 receptor, hasOrthologIn, rat Cnr2]
-
A.
C2r
C2r is the standard magnetic polarity chron code assigned to the Gauss–Matuyama geomagnetic reversal interval in the geomagnetic polarity timescale.
-
B.
CNR
CNR is an acronym commonly used for the College of Natural Resources, an academic unit focused on environmental science, resource management, and related fields.
-
C.
CNR
CNR is the stock ticker symbol for Canadian National Railway, a major North American freight railway company.
-
D.
R2N
R2N is the symbol used to designate the R2 Nord commuter rail line in the Barcelona suburban railway network.
-
E.
RANC
RANC is the Royal Australian Navy’s principal officer training institution, responsible for educating and preparing naval officers for service.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: rat Cnr2 Target entity description: Rat Cnr2 is the rat gene encoding the cannabinoid receptor type 2 (CB2), a G protein–coupled receptor involved in modulating immune and inflammatory responses.
-
A.
C2r
C2r is the standard magnetic polarity chron code assigned to the Gauss–Matuyama geomagnetic reversal interval in the geomagnetic polarity timescale.
-
B.
CNR
CNR is an acronym commonly used for the College of Natural Resources, an academic unit focused on environmental science, resource management, and related fields.
-
C.
CNR
CNR is the stock ticker symbol for Canadian National Railway, a major North American freight railway company.
-
D.
R2N
R2N is the symbol used to designate the R2 Nord commuter rail line in the Barcelona suburban railway network.
-
E.
RANC
RANC is the Royal Australian Navy’s principal officer training institution, responsible for educating and preparing naval officers for service.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
gene
ⓘ
protein-coding gene ⓘ |
| associatedProtein | CB2 ⓘ |
| associatedWith |
anti-inflammatory effects
ⓘ
immunomodulation ⓘ |
| biologicalProcess |
G protein–coupled receptor signaling pathway
ⓘ
immune response modulation ⓘ inflammatory response modulation ⓘ neuroinflammatory response ⓘ regulation of cytokine production ⓘ regulation of pain perception ⓘ signal transduction ⓘ |
| cellularLocation |
cell surface
ⓘ
plasma membrane ⓘ |
| couplesTo | Gi/o proteins ⓘ |
| effectOfActivation |
decrease in intracellular cAMP levels
ⓘ
inhibition of adenylyl cyclase ⓘ modulation of ion channel activity ⓘ |
| encodes |
CB2 receptor
ⓘ
cannabinoid receptor type 2 ⓘ |
| expressedIn |
B lymphocytes
ⓘ
immune cells ⓘ lymph nodes ⓘ macrophages ⓘ microglia ⓘ spleen ⓘ |
| fullName |
cannabinoid receptor 2 (macrophage)
ⓘ
linked to:
CB2 receptor
|
| geneSymbol | Cnr2 ⓘ |
| ligand |
2-arachidonoylglycerol
ⓘ
anandamide ⓘ endocannabinoids ⓘ synthetic cannabinoid agonists ⓘ |
| locatedIn | rat genome ⓘ |
| molecularFunction |
G protein–coupled receptor activity
ⓘ
GTPase activity modulation via G proteins ⓘ cannabinoid receptor activity ⓘ |
| organism |
Rattus norvegicus
ⓘ
linked to:
Norway rat (Rattus norvegicus)
|
| orthologOf |
human CNR2
ⓘ
mouse Cnr2 ⓘ |
| pathway | endocannabinoid signaling pathway ⓘ |
| receptorType |
G protein–coupled receptor
ⓘ
class A rhodopsin-like GPCR ⓘ |
| relatedTo |
endocannabinoid system
ⓘ
pain and inflammation pathways ⓘ |
| species | rat ⓘ |
| targetOf |
cannabinoid receptor agonists
ⓘ
cannabinoid receptor antagonists ⓘ |
| usedIn |
rat models of inflammation
ⓘ
rat models of neuropathic pain ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: rat Cnr2 Description of subject: Rat Cnr2 is the rat gene encoding the cannabinoid receptor type 2 (CB2), a G protein–coupled receptor involved in modulating immune and inflammatory responses.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.