hepatitis C virus
E902136
Hepatitis C virus is a bloodborne RNA virus that primarily infects the liver, often causing chronic hepatitis, cirrhosis, and an increased risk of liver cancer.
All labels observed (3)
| Label | Occurrences |
|---|---|
| Hepacivirus C | 1 |
| hepatitis C virus canonical | 1 |
| non-A, non-B hepatitis virus | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074031 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: hepatitis C virus Context triple: [Cepheid, developsTestFor, hepatitis C virus]
-
A.
JC virus
JC virus is a human polyomavirus that typically causes asymptomatic infection but can lead to severe demyelinating brain disease in immunocompromised individuals.
-
B.
John Cunningham virus
John Cunningham virus is a human polyomavirus that typically remains latent but can cause the severe demyelinating brain disease progressive multifocal leukoencephalopathy in immunocompromised individuals.
-
C.
Nadvirna
Nadvirna is a town in western Ukraine known as a local administrative and industrial center in the Ivano-Frankivsk region.
-
D.
HFLD
HFLD is a shorthand reference to Luke Bryan’s country song “Huntin’, Fishin’ and Lovin’ Every Day,” which celebrates an outdoors-oriented, small-town lifestyle.
-
E.
HIV-1
HIV-1 is the primary virus responsible for the global HIV/AIDS pandemic, characterized by its rapid mutation and attack on the human immune system’s CD4+ T cells.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: hepatitis C virus Target entity description: Hepatitis C virus is a bloodborne RNA virus that primarily infects the liver, often causing chronic hepatitis, cirrhosis, and an increased risk of liver cancer.
-
A.
JC virus
JC virus is a human polyomavirus that typically causes asymptomatic infection but can lead to severe demyelinating brain disease in immunocompromised individuals.
-
B.
John Cunningham virus
John Cunningham virus is a human polyomavirus that typically remains latent but can cause the severe demyelinating brain disease progressive multifocal leukoencephalopathy in immunocompromised individuals.
-
C.
Nadvirna
Nadvirna is a town in western Ukraine known as a local administrative and industrial center in the Ivano-Frankivsk region.
-
D.
HFLD
HFLD is a shorthand reference to Luke Bryan’s country song “Huntin’, Fishin’ and Lovin’ Every Day,” which celebrates an outdoors-oriented, small-town lifestyle.
-
E.
HIV-1
HIV-1 is the primary virus responsible for the global HIV/AIDS pandemic, characterized by its rapid mutation and attack on the human immune system’s CD4+ T cells.
- F. None of above. chosen
Statements (79)
| Predicate | Object |
|---|---|
| instanceOf |
bloodborne pathogen
ⓘ
hepatitis virus ⓘ virus ⓘ |
| associatedDisease |
acute hepatitis C
ⓘ
chronic hepatitis C ⓘ extrahepatic manifestations ⓘ hepatitis C ⓘ hepatocellular carcinoma ⓘ liver cirrhosis ⓘ membranoproliferative glomerulonephritis ⓘ mixed cryoglobulinemia ⓘ |
| diagnosedBy |
HCV RNA PCR test
ⓘ
anti-HCV antibody test ⓘ |
| discoveredBy |
Charles M. Rice
ⓘ
Harvey J. Alter ⓘ Michael Houghton ⓘ |
| discoveryYear | 1989 ⓘ |
| encodesProtein |
NS2 protein
ⓘ
NS3 protease-helicase ⓘ NS4A protein ⓘ NS4B protein ⓘ NS5A protein ⓘ
linked to:
HCV NS5A protein
NS5B RNA-dependent RNA polymerase ⓘ
linked to:
HCV NS5B RNA-dependent RNA polymerase
core protein ⓘ envelope glycoprotein E1 ⓘ envelope glycoprotein E2 ⓘ |
| entryReceptor |
CD81
ⓘ
SR-BI ⓘ claudin-1 ⓘ occludin ⓘ |
| enveloped | true ⓘ |
| family | Flaviviridae ⓘ |
| genomeLength | approximately 9600 nucleotides ⓘ |
| genomeOrganization | single open reading frame ⓘ |
| genomePolarity | positive-sense ⓘ |
| genomeSegmented | non-segmented ⓘ |
| genomeStrandedness | single-stranded ⓘ |
| genomeType | single-stranded RNA ⓘ |
| genus | Hepacivirus ⓘ |
| globalBurden | major cause of chronic liver disease worldwide ⓘ |
| hasGenotype |
genotype 1
ⓘ
genotype 2 ⓘ genotype 3 ⓘ genotype 4 ⓘ genotype 5 ⓘ genotype 6 ⓘ genotype 7 ⓘ |
| hasVaccine | false ⓘ |
| order | Amarillovirales ⓘ |
| parentTaxon |
Hepacivirus C
ⓘ
linked to:
hepatitis C virus
|
| previousName |
non-A, non-B hepatitis virus
ⓘ
linked to:
hepatitis C virus
|
| primaryPreventionMethod |
harm reduction for injection drug use
ⓘ
infection control in healthcare settings ⓘ safe injection practices ⓘ screening of blood products ⓘ |
| primaryTargetOrgan | liver ⓘ |
| primaryTropism | hepatocytes ⓘ |
| replicationSite | cytoplasm of hepatocytes ⓘ |
| riskFactorFor |
end-stage liver disease
ⓘ
liver transplantation ⓘ |
| shape | spherical ⓘ |
| taxonRank | species ⓘ |
| transmissionRoute |
bloodborne
ⓘ
contaminated blood transfusion ⓘ inadequately sterilized medical equipment ⓘ needle sharing ⓘ occupational exposure ⓘ parenteral ⓘ percutaneous exposure ⓘ vertical transmission ⓘ |
| treatedBy |
NS3/4A protease inhibitors
ⓘ
NS5A inhibitors ⓘ NS5B polymerase inhibitors ⓘ direct-acting antivirals ⓘ glecaprevir ⓘ ledipasvir ⓘ pibrentasvir ⓘ sofosbuvir ⓘ
linked to:
Sovaldi
velpatasvir ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: hepatitis C virus Description of subject: Hepatitis C virus is a bloodborne RNA virus that primarily infects the liver, often causing chronic hepatitis, cirrhosis, and an increased risk of liver cancer.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: hepatitis C virus
linked to: hepatitis C virus