HCV NS5B RNA-dependent RNA polymerase
E1239451
UNEXPLORED
HCV NS5B RNA-dependent RNA polymerase is the viral enzyme in hepatitis C virus responsible for replicating its RNA genome and a key target for direct-acting antiviral drugs.
All labels observed (3)
| Label | Occurrences |
|---|---|
| HCV NS5B RNA-dependent RNA polymerase canonical | 1 |
| HCV NS5B polymerase | 1 |
| NS5B RNA-dependent RNA polymerase | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T16852061 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: HCV NS5B RNA-dependent RNA polymerase Context triple: [Harvoni, hasTarget, HCV NS5B RNA-dependent RNA polymerase]
-
A.
HCV NS5A protein
HCV NS5A protein is a multifunctional nonstructural hepatitis C virus protein essential for viral RNA replication and assembly, and a key target of several direct-acting antiviral drugs.
-
B.
HIV-1 reverse transcriptase
HIV-1 reverse transcriptase is a viral enzyme that converts the HIV-1 RNA genome into DNA, making it a key target for antiretroviral drugs used in HIV treatment.
-
C.
HIV-1 integrase
HIV-1 integrase is a viral enzyme that inserts HIV-1’s genetic material into the host cell’s DNA, making it a key target for antiretroviral drugs.
-
D.
SARS-CoV-2 RNA-dependent RNA polymerase
SARS-CoV-2 RNA-dependent RNA polymerase is the key viral enzyme responsible for replicating the coronavirus’s RNA genome and is a primary target for antiviral drugs such as remdesivir.
-
E.
hepatitis C virus
Hepatitis C virus is a bloodborne RNA virus that primarily infects the liver, often causing chronic hepatitis, cirrhosis, and an increased risk of liver cancer.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: HCV NS5B RNA-dependent RNA polymerase Target entity description: HCV NS5B RNA-dependent RNA polymerase is the viral enzyme in hepatitis C virus responsible for replicating its RNA genome and a key target for direct-acting antiviral drugs.
-
A.
HCV NS5A protein
HCV NS5A protein is a multifunctional nonstructural hepatitis C virus protein essential for viral RNA replication and assembly, and a key target of several direct-acting antiviral drugs.
-
B.
HIV-1 reverse transcriptase
HIV-1 reverse transcriptase is a viral enzyme that converts the HIV-1 RNA genome into DNA, making it a key target for antiretroviral drugs used in HIV treatment.
-
C.
HIV-1 integrase
HIV-1 integrase is a viral enzyme that inserts HIV-1’s genetic material into the host cell’s DNA, making it a key target for antiretroviral drugs.
-
D.
SARS-CoV-2 RNA-dependent RNA polymerase
SARS-CoV-2 RNA-dependent RNA polymerase is the key viral enzyme responsible for replicating the coronavirus’s RNA genome and is a primary target for antiviral drugs such as remdesivir.
-
E.
hepatitis C virus
Hepatitis C virus is a bloodborne RNA virus that primarily infects the liver, often causing chronic hepatitis, cirrhosis, and an increased risk of liver cancer.
- F. None of above. chosen
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: HCV NS5B RNA-dependent RNA polymerase