Restless legs syndrome
E873102
Restless legs syndrome is a neurological sleep-related disorder characterized by an uncontrollable urge to move the legs, typically worsening at rest and at night.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Restless legs syndrome canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10582929 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Restless legs syndrome Context triple: [Sleep, hasDisorder, Restless legs syndrome]
-
A.
Restless Heart Syndrome
"Restless Heart Syndrome" is a song by American punk rock band Green Day from their rock opera album "21st Century Breakdown," known for its introspective lyrics and dynamic shifts in musical style.
-
B.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
-
C.
The Asthenic Syndrome
The Asthenic Syndrome is a 1989 Soviet black comedy-drama film by Kira Muratova, renowned for its experimental structure and bleak, satirical portrayal of late-Soviet society.
-
D.
Insomnias
"Insomnias" is a surrealist work by American artist Dorothea Tanning, reflecting her dreamlike, psychologically charged style.
-
E.
multiple system atrophy
Multiple system atrophy is a rare, progressive neurodegenerative disorder characterized by a combination of autonomic failure, parkinsonism, and/or cerebellar ataxia due to widespread nervous system damage.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Restless legs syndrome Target entity description: Restless legs syndrome is a neurological sleep-related disorder characterized by an uncontrollable urge to move the legs, typically worsening at rest and at night.
-
A.
Restless Heart Syndrome
"Restless Heart Syndrome" is a song by American punk rock band Green Day from their rock opera album "21st Century Breakdown," known for its introspective lyrics and dynamic shifts in musical style.
-
B.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
-
C.
The Asthenic Syndrome
The Asthenic Syndrome is a 1989 Soviet black comedy-drama film by Kira Muratova, renowned for its experimental structure and bleak, satirical portrayal of late-Soviet society.
-
D.
Insomnias
"Insomnias" is a surrealist work by American artist Dorothea Tanning, reflecting her dreamlike, psychologically charged style.
-
E.
multiple system atrophy
Multiple system atrophy is a rare, progressive neurodegenerative disorder characterized by a combination of autonomic failure, parkinsonism, and/or cerebellar ataxia due to widespread nervous system damage.
- F. None of above. chosen
Statements (74)
| Predicate | Object |
|---|---|
| instanceOf |
chronic condition
ⓘ
neurological disorder ⓘ sleep-related movement disorder ⓘ |
| affectsBodyPart | legs ⓘ |
| affectsSystem | nervous system ⓘ |
| hasAssociatedCondition |
Parkinson's disease
ⓘ
diabetes mellitus ⓘ end-stage renal disease ⓘ iron deficiency ⓘ iron-deficiency anemia ⓘ peripheral neuropathy ⓘ pregnancy ⓘ rheumatoid arthritis ⓘ |
| hasAssociatedNeurotransmitter | dopamine ⓘ |
| hasAssociatedNutrient | iron ⓘ |
| hasComplication | augmentation with long-term dopaminergic therapy ⓘ |
| hasCoreSymptom |
difficulty falling asleep
ⓘ
sleep fragmentation ⓘ symptoms worse at rest ⓘ symptoms worse in the evening or at night ⓘ temporary relief with movement ⓘ uncomfortable sensations in the legs ⓘ urge to move the legs ⓘ |
| hasDiagnosticCriterion |
symptoms are not solely accounted for by another medical or behavioral condition
ⓘ
symptoms are partially or totally relieved by movement ⓘ symptoms are worse in the evening or at night than during the day ⓘ symptoms begin or worsen during periods of rest or inactivity ⓘ urge to move the legs usually accompanied by uncomfortable sensations ⓘ |
| hasEpidemiology | affects a few percent of the adult population ⓘ |
| hasGeneticComponent | yes ⓘ |
| hasHeritability | often runs in families ⓘ |
| hasImpact |
increased risk of depression
ⓘ
reduced quality of life ⓘ reduced sleep quality ⓘ |
| hasNonPharmacologicTreatment |
avoiding caffeine and alcohol in the evening
ⓘ
hot or cold baths ⓘ leg massage ⓘ moderate regular exercise ⓘ pneumatic compression devices ⓘ sleep hygiene measures ⓘ |
| hasOnsetPattern |
symptoms may begin in childhood or adolescence
ⓘ
symptoms often begin in adulthood ⓘ |
| hasPathophysiologyHypothesis |
brain iron deficiency
ⓘ
central dopaminergic dysfunction ⓘ |
| hasPharmacologicTreatment |
alpha-2-delta ligands
ⓘ
benzodiazepines for sleep ⓘ dopamine agonists ⓘ gabapentin ⓘ iron supplementation when iron deficient ⓘ levodopa ⓘ opioids in refractory cases ⓘ pregabalin ⓘ
linked to:
Lyrica
|
| hasPossibleSymptom |
daytime fatigue
ⓘ
impaired concentration ⓘ mood disturbances ⓘ |
| hasPrevalence |
more common in women than in men
ⓘ
prevalence increases with age ⓘ |
| hasRiskFactor |
family history of restless legs syndrome
ⓘ
female sex ⓘ older age ⓘ pregnancy ⓘ |
| hasSubtype |
primary restless legs syndrome
ⓘ
secondary restless legs syndrome ⓘ |
| hasSynonym |
RLS
ⓘ
Willis–Ekbom disease ⓘ |
| hasTypicalCourse |
symptoms may fluctuate over time
ⓘ
symptoms often progress in severity ⓘ |
| isChronic | often lifelong ⓘ |
| isClassifiedIn |
ICD-10 G25.81
ⓘ
ICD-11 8D80 ⓘ
linked to:
International Classification of Diseases
|
| isDistinguishedFrom |
akathisia
ⓘ
nocturnal leg cramps ⓘ peripheral neuropathy ⓘ |
| isListedIn | DSM-5 as a sleep-wake disorder ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Restless legs syndrome Description of subject: Restless legs syndrome is a neurological sleep-related disorder characterized by an uncontrollable urge to move the legs, typically worsening at rest and at night.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.