NADPH
E850008
NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) is a key cellular coenzyme that donates electrons in biosynthetic reactions and antioxidant defense pathways.
All labels observed (1)
| Label | Occurrences |
|---|---|
| NADPH canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10214753 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: NADPH Context triple: [CYP3A4, requiresCofactor, NADPH]
-
A.
NAD+
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme in cellular redox reactions and energy metabolism, central to processes like glycolysis, the TCA cycle, and oxidative phosphorylation.
-
B.
NAD
NAD is the three-letter ISO 4217 currency code for the Namibian dollar, the official currency of Namibia.
-
C.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
-
D.
PQQ
PQQ is the IATA airport code for Port Macquarie Airport in New South Wales, Australia.
-
E.
Neogranadine
Neogranadine refers to an inhabitant or native of the former Republic of New Granada, a 19th-century state in northern South America that encompassed much of present-day Colombia and surrounding regions.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: NADPH Target entity description: NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) is a key cellular coenzyme that donates electrons in biosynthetic reactions and antioxidant defense pathways.
-
A.
NAD+
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme in cellular redox reactions and energy metabolism, central to processes like glycolysis, the TCA cycle, and oxidative phosphorylation.
-
B.
NAD
NAD is the three-letter ISO 4217 currency code for the Namibian dollar, the official currency of Namibia.
-
C.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
-
D.
PQQ
PQQ is the IATA airport code for Port Macquarie Airport in New South Wales, Australia.
-
E.
Neogranadine
Neogranadine refers to an inhabitant or native of the former Republic of New Granada, a 19th-century state in northern South America that encompassed much of present-day Colombia and surrounding regions.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
coenzyme
ⓘ
reduced nicotinamide adenine dinucleotide phosphate ⓘ |
| chemicalFormula | C21H30N7O17P3 ⓘ |
| differsFrom | NADH by an extra phosphate group on the ribose of the adenosine moiety ⓘ |
| donates |
electrons
ⓘ
hydride ion ⓘ |
| hasCharge | -3 ⓘ |
| hasComponent |
adenine
ⓘ
nicotinamide ⓘ phosphate group ⓘ pyrophosphate bridge ⓘ ribose ⓘ |
| hasRedoxState | reduced ⓘ |
| hasRole |
antioxidant system cofactor
ⓘ
biosynthetic cofactor ⓘ detoxification cofactor ⓘ reducing equivalent donor ⓘ |
| isChemicallySimilarTo |
NADH
ⓘ
linked to:
NAD+
|
| isCofactorFor |
HMG-CoA reductase
ⓘ
NADPH oxidase ⓘ cytochrome P450 reductase ⓘ fatty acid synthase ⓘ glutathione reductase ⓘ nitric oxide synthase ⓘ thioredoxin reductase ⓘ |
| isConjugateWith | NADP+ ⓘ |
| isMoreAbundantIn | cytosol ⓘ |
| isProducedBy |
NADP+-dependent isocitrate dehydrogenase
ⓘ
malic enzyme reaction ⓘ oxidative branch of pentose phosphate pathway ⓘ pentose phosphate pathway ⓘ photosystem I ⓘ |
| isRequiredFor |
cholesterol synthesis
ⓘ
fatty acid chain elongation ⓘ maintenance of reduced glutathione ⓘ reactive oxygen species generation in immune cells ⓘ regeneration of ascorbate ⓘ |
| participatesIn |
anabolic metabolism
ⓘ
antioxidant defense ⓘ cholesterol biosynthesis ⓘ cytochrome P450–dependent reactions ⓘ deoxyribonucleotide synthesis ⓘ fatty acid synthesis ⓘ glutathione reduction ⓘ nitric oxide synthesis ⓘ nucleotide biosynthesis ⓘ photosynthetic carbon fixation ⓘ respiratory burst in phagocytes ⓘ steroid hormone biosynthesis ⓘ thioredoxin reduction ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: NADPH Description of subject: NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) is a key cellular coenzyme that donates electrons in biosynthetic reactions and antioxidant defense pathways.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.