platelet-derived growth factor

E681666

Platelet-derived growth factor is a key signaling protein that regulates cell growth, proliferation, and angiogenesis, and plays important roles in wound healing and various pathological conditions such as cancer and fibrosis.

All labels observed (10)

Label Occurrences
PDGF 1
PDGF-A chain 1
PDGF-B chain 1

How this entity was disambiguated

Statements (54)

Predicate Object
instanceOf cytokine ⓘ
growth factor ⓘ
mitogen ⓘ
signaling protein ⓘ
activates JAK-STAT signaling pathway ⓘ
MAPK signaling pathway ⓘ
PI3K-AKT signaling pathway ⓘ
receptor tyrosine kinases ⓘ
alternativeName PDGF ⓘ
associatedWith atherosclerosis ⓘ
cancer ⓘ
diabetic retinopathy ⓘ
fibrosis ⓘ
idiopathic pulmonary fibrosis ⓘ
pulmonary arterial hypertension ⓘ
bindsTo PDGF receptor alpha ⓘ
PDGF receptor beta ⓘ
linked to: PDGFRβ
composedOf PDGF-A chain ⓘ
PDGF-B chain ⓘ
PDGF-C chain ⓘ
PDGF-D chain ⓘ
discoveredIn 1970s ⓘ
encodedBy PDGFA gene ⓘ
PDGFB gene ⓘ
PDGFC gene ⓘ
PDGFD gene ⓘ
forms PDGF-AA dimer ⓘ
PDGF-AB dimer ⓘ
PDGF-BB dimer ⓘ
PDGF-CC dimer ⓘ
PDGF-DD dimer ⓘ
foundIn platelet alpha granules ⓘ
involvedIn embryonic development ⓘ
tissue repair ⓘ
wound healing ⓘ
producedBy endothelial cells ⓘ
fibroblasts ⓘ
macrophages ⓘ
platelets ⓘ
smooth muscle cells ⓘ
promotes chemotaxis of mesenchymal cells ⓘ
pericyte recruitment ⓘ
vascular remodeling ⓘ
regulates angiogenesis ⓘ
cell growth ⓘ
cell migration ⓘ
cell proliferation ⓘ
stimulates extracellular matrix production ⓘ
fibroblast proliferation ⓘ
smooth muscle cell proliferation ⓘ
targetCellType fibroblasts ⓘ
glial cells ⓘ
mesenchymal cells ⓘ
smooth muscle cells ⓘ

How these facts were elicited

Referenced by (10)

Full triples — surface form annotated when it differs from this entity's canonical label.

Carl-Henrik Heldin → fieldOfWork → platelet-derived growth factor ⓘ
platelet-derived growth factor → composedOf → PDGF-A chain ⓘ
linked to: platelet-derived growth factor
platelet-derived growth factor → composedOf → PDGF-B chain ⓘ
linked to: platelet-derived growth factor
platelet-derived growth factor → composedOf → PDGF-C chain ⓘ
linked to: platelet-derived growth factor
platelet-derived growth factor → composedOf → PDGF-D chain ⓘ
linked to: platelet-derived growth factor
platelet-derived growth factor → encodedBy → PDGFA gene ⓘ
linked to: platelet-derived growth factor
platelet-derived growth factor → encodedBy → PDGFB gene ⓘ
linked to: platelet-derived growth factor
platelet-derived growth factor → encodedBy → PDGFC gene ⓘ
linked to: platelet-derived growth factor
platelet-derived growth factor → encodedBy → PDGFD gene ⓘ
linked to: platelet-derived growth factor
Power Data Grapple Fixture → abbreviation → PDGF ⓘ
linked to: platelet-derived growth factor