NIH High-Risk, High-Reward Research program
E645744
The NIH High-Risk, High-Reward Research program is a flagship National Institutes of Health initiative that supports exceptionally innovative and potentially transformative biomedical and behavioral research by funding investigators with bold, unconventional ideas.
All labels observed (3)
| Label | Occurrences |
|---|---|
| NIH High-Risk, High-Reward Research program canonical | 4 |
| High-Risk, High-Reward Research Program | 1 |
| NIH Common Fund High-Risk, High-Reward Research Program | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T7156912 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: NIH High-Risk, High-Reward Research program Context triple: [NIH Director’s Pioneer Award, sponsor, NIH High-Risk, High-Reward Research program]
-
A.
Clinical and Translational Science Awards Program
The Clinical and Translational Science Awards Program is a U.S. national consortium that supports academic medical institutions in accelerating the translation of scientific discoveries into improved patient care and public health.
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B.
Basic Research Challenge program
The Basic Research Challenge program is a U.S. Office of Naval Research initiative that funds high-risk, high-reward multidisciplinary basic science projects to advance naval-relevant technologies and knowledge.
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C.
National Institutes of Health intramural research program
The National Institutes of Health intramural research program is a large, government-funded biomedical research enterprise in which NIH scientists conduct basic, translational, and clinical studies within NIH facilities.
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D.
Small Business Innovation Research program
The Small Business Innovation Research program is a U.S. government initiative that provides competitive funding to small businesses for research and development with strong commercialization potential.
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E.
NIH Director’s Pioneer Award
The NIH Director’s Pioneer Award is a prestigious U.S. biomedical research grant that provides substantial, flexible funding to exceptionally creative scientists pursuing highly innovative, high-risk research.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: NIH High-Risk, High-Reward Research program Target entity description: The NIH High-Risk, High-Reward Research program is a flagship National Institutes of Health initiative that supports exceptionally innovative and potentially transformative biomedical and behavioral research by funding investigators with bold, unconventional ideas.
-
A.
Clinical and Translational Science Awards Program
The Clinical and Translational Science Awards Program is a U.S. national consortium that supports academic medical institutions in accelerating the translation of scientific discoveries into improved patient care and public health.
-
B.
Basic Research Challenge program
The Basic Research Challenge program is a U.S. Office of Naval Research initiative that funds high-risk, high-reward multidisciplinary basic science projects to advance naval-relevant technologies and knowledge.
-
C.
National Institutes of Health intramural research program
The National Institutes of Health intramural research program is a large, government-funded biomedical research enterprise in which NIH scientists conduct basic, translational, and clinical studies within NIH facilities.
-
D.
Small Business Innovation Research program
The Small Business Innovation Research program is a U.S. government initiative that provides competitive funding to small businesses for research and development with strong commercialization potential.
-
E.
NIH Director’s Pioneer Award
The NIH Director’s Pioneer Award is a prestigious U.S. biomedical research grant that provides substantial, flexible funding to exceptionally creative scientists pursuing highly innovative, high-risk research.
- F. None of above. chosen
Statements (41)
| Predicate | Object |
|---|---|
| instanceOf |
National Institutes of Health program
ⓘ
research funding program ⓘ |
| administeredBy | National Institutes of Health ⓘ |
| aimsTo |
catalyze novel approaches to major challenges in health and disease
ⓘ
support projects that may not fare well in conventional peer review ⓘ |
| country |
United States
ⓘ
linked to:
United States of America
|
| emphasizes |
investigator creativity
ⓘ
potential for paradigm-shifting discoveries ⓘ |
| encourages |
interdisciplinary research
ⓘ
non-traditional research approaches ⓘ |
| evaluationEmphasis |
originality of research vision
ⓘ
potential impact over preliminary data ⓘ |
| field |
behavioral sciences
ⓘ
biomedical sciences ⓘ |
| focusesOn |
high-reward research
ⓘ
high-risk research ⓘ innovative research ⓘ transformative research ⓘ |
| fundingAgency | U.S. Department of Health and Human Services ⓘ |
| fundingMechanism | competitive grants ⓘ |
| funds | individual investigators ⓘ |
| hasGoal |
accelerate scientific breakthroughs
ⓘ
encourage bold and unconventional ideas ⓘ support exceptionally creative scientists ⓘ |
| includes |
NIH Early Independence Award
ⓘ
NIH New Innovator Award ⓘ
linked to:
NIH Director’s New Innovator Award
NIH Pioneer Award ⓘ
linked to:
NIH Director’s Pioneer Award
NIH Transformative Research Award ⓘ |
| partOf |
NIH Common Fund initiatives
ⓘ
linked to:
NIH Common Fund
|
| selectionCriteria |
impact potential
ⓘ
innovation ⓘ risk tolerance ⓘ |
| sponsor |
behavioral research
ⓘ
biomedical research ⓘ |
| supports |
early-stage investigators
ⓘ
established investigators ⓘ |
| supportsResearchType |
basic research
ⓘ
clinical research ⓘ translational research ⓘ |
| targetOutcome |
improvements in human health
ⓘ
major advances in biomedical knowledge ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: NIH High-Risk, High-Reward Research program Description of subject: The NIH High-Risk, High-Reward Research program is a flagship National Institutes of Health initiative that supports exceptionally innovative and potentially transformative biomedical and behavioral research by funding investigators with bold, unconventional ideas.
Referenced by (6)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: NIH High-Risk, High-Reward Research program
NIH Transformative Research Award
→
partOf
→
NIH Common Fund High-Risk, High-Reward Research Program
ⓘ
linked to: NIH High-Risk, High-Reward Research program