SMCR8
E561100
SMCR8 is a protein implicated in autophagy and lysosomal regulation, often studied for its functional partnership with C9orf72 in neurodegenerative disease pathways.
All labels observed (2)
| Label | Occurrences |
|---|---|
| SMCR8 protein | 2 |
| SMCR8 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004832 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: SMCR8 Context triple: [C9orf72, interactsWith, SMCR8]
-
A.
MCR
The MCR is the Middle Common Room, a postgraduate student community and social organization within Jesus College.
-
B.
MRC
MRC is an American independent film and television studio known for producing and financing a wide range of acclaimed movies and TV series.
-
C.
MRC
MRC is a major UK organization that funds and supports medical research to improve human health.
-
D.
MRC
MRC is an intergovernmental organization that coordinates sustainable development and management of the Mekong River basin among its member countries.
-
E.
MCRC
MCRC is the United States Marine Corps Recruiting Command responsible for enlisting and accessing new Marines into the Corps.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: SMCR8 Target entity description: SMCR8 is a protein implicated in autophagy and lysosomal regulation, often studied for its functional partnership with C9orf72 in neurodegenerative disease pathways.
-
A.
MCR
The MCR is the Middle Common Room, a postgraduate student community and social organization within Jesus College.
-
B.
MRC
MRC is a major UK organization that funds and supports medical research to improve human health.
-
C.
MRC
MRC is an American independent film and television studio known for producing and financing a wide range of acclaimed movies and TV series.
-
D.
MRC
MRC is an intergovernmental organization that coordinates sustainable development and management of the Mekong River basin among its member countries.
-
E.
MCRC
MCRC is the United States Marine Corps Recruiting Command responsible for enlisting and accessing new Marines into the Corps.
- F. None of above. chosen
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
autophagy regulator
ⓘ
lysosomal regulator ⓘ protein ⓘ |
| associatedWith |
C9orf72
ⓘ
amyotrophic lateral sclerosis ⓘ frontotemporal dementia ⓘ neurodegeneration ⓘ |
| encodedIn | Homo sapiens genome ⓘ |
| expressedIn |
brain
ⓘ
immune cells ⓘ neurons ⓘ |
| formsComplexWith |
C9orf72
ⓘ
WDR41 ⓘ |
| fullName |
SMCR8 protein
ⓘ
linked to:
SMCR8
|
| geneticInteractionWith | C9orf72 ⓘ |
| interactsWith | Rab GTPases ⓘ |
| involvedIn |
TFEB regulation
ⓘ
autophagy ⓘ endolysosomal trafficking ⓘ lysosomal homeostasis ⓘ lysosome biogenesis regulation ⓘ mTORC1 signaling regulation ⓘ macroautophagy ⓘ neuronal homeostasis ⓘ |
| localizesTo |
autophagosome
ⓘ
cytoplasm ⓘ endosome ⓘ lysosome ⓘ |
| lossOfFunctionLeadsTo |
abnormal lysosomal accumulation
ⓘ
altered mTORC1 signaling ⓘ impaired autophagy ⓘ |
| molecularFunction | putative DENN-like Rab-GEF activity ⓘ |
| negativelyRegulates | mTORC1 activity ⓘ |
| orthologFoundIn |
Drosophila melanogaster
ⓘ
mouse ⓘ zebrafish ⓘ |
| participatesIn |
C9orf72–SMCR8–WDR41 complex
ⓘ
linked to:
SMCR8-WDR41 complex
|
| positivelyRegulates | TFEB nuclear translocation ⓘ |
| regulates |
autophagic flux
ⓘ
lysosomal exocytosis ⓘ lysosomal positioning ⓘ |
| requiredFor | C9orf72 protein stability ⓘ |
| stabilizes |
C9orf72 protein
ⓘ
linked to:
C9orf72
|
| studiedInContextOf |
C9orf72-related ALS
ⓘ
linked to:
C9orf72
C9orf72-related FTD ⓘ |
| taxon | Homo sapiens ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: SMCR8 Description of subject: SMCR8 is a protein implicated in autophagy and lysosomal regulation, often studied for its functional partnership with C9orf72 in neurodegenerative disease pathways.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: SMCR8