WDR41
E561101
WDR41 is a WD repeat-containing protein implicated in autophagy and lysosomal function, often studied in the context of neurodegenerative disease–related pathways.
All labels observed (1)
| Label | Occurrences |
|---|---|
| WDR41 canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T6004833 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: WDR41 Context triple: [C9orf72, interactsWith, WDR41]
-
A.
W4
W4 is a prominent star-forming region in the Milky Way, notable for its large ionized gas bubble and active formation of massive young stars.
-
B.
S41
S41 is a circular Berlin S-Bahn line that runs clockwise around the city’s Ringbahn, connecting numerous districts in a loop.
-
C.
WDG
WDG is the abbreviated name for Wizards District Gaming, the NBA 2K League esports team affiliated with the Washington Wizards.
-
D.
RWR
RWR is the abbreviation for the Royal Winnipeg Rifles, an infantry regiment of the Canadian Army Reserve based in Winnipeg, Manitoba.
-
E.
WQD
WQD is the commonly used abbreviation for World Quaker Day, an annual event celebrating the global Quaker community.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: WDR41 Target entity description: WDR41 is a WD repeat-containing protein implicated in autophagy and lysosomal function, often studied in the context of neurodegenerative disease–related pathways.
-
A.
W4
W4 is a prominent star-forming region in the Milky Way, notable for its large ionized gas bubble and active formation of massive young stars.
-
B.
S41
S41 is a circular Berlin S-Bahn line that runs clockwise around the city’s Ringbahn, connecting numerous districts in a loop.
-
C.
WDG
WDG is the abbreviated name for Wizards District Gaming, the NBA 2K League esports team affiliated with the Washington Wizards.
-
D.
RWR
RWR is the abbreviation for the Royal Winnipeg Rifles, an infantry regiment of the Canadian Army Reserve based in Winnipeg, Manitoba.
-
E.
WQD
WQD is the commonly used abbreviation for World Quaker Day, an annual event celebrating the global Quaker community.
- F. None of above. chosen
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
human gene
ⓘ
protein ⓘ |
| associatedWith |
autophagy-related signaling pathways
ⓘ
lysosomal storage pathways ⓘ mTOR signaling regulation ⓘ neurodegenerative disease–related pathways ⓘ |
| binds |
PIKfyve
ⓘ
VAC14 ⓘ lysosomal membranes ⓘ |
| conservedIn | vertebrates ⓘ |
| containsDomain | WD repeat domain ⓘ |
| encodes | WD repeat-containing protein 41 ⓘ |
| expressedIn |
human brain
ⓘ
multiple human tissues ⓘ neurons ⓘ |
| geneType | protein-coding gene ⓘ |
| hasFullName |
WD repeat domain 41
ⓘ
linked to:
SMCR8-WDR41 complex
|
| hasGeneSymbol | WDR41 ⓘ |
| hasMolecularFunction |
protein binding
ⓘ
scaffold protein activity ⓘ |
| hasProteinFeature | beta-propeller structure ⓘ |
| hasRepeatType | WD40 repeat ⓘ |
| involvedIn |
autophagosome-lysosome fusion
ⓘ
autophagy ⓘ lysosomal function ⓘ lysosome biogenesis ⓘ macroautophagy ⓘ neuronal homeostasis ⓘ |
| locatedOnChromosome | human chromosome 5 ⓘ |
| lossOfFunctionPhenotype |
accumulation of autophagic substrates
ⓘ
defective lysosomal function ⓘ impaired autophagic flux ⓘ |
| orthologIn |
mouse Wdr41
ⓘ
zebrafish wdr41 ⓘ |
| participatesIn |
endosomal-lysosomal pathway
ⓘ
phosphoinositide metabolism regulation ⓘ |
| participatesInComplex | PIKfyve-VAC14-FIG4 complex ⓘ |
| regulates |
endolysosomal trafficking
ⓘ
lysosomal nutrient sensing ⓘ |
| studiedInContextOf |
ALS-related pathways
ⓘ
Parkinson disease–related pathways ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
endolysosomal compartment ⓘ lysosome ⓘ |
| taxon | Homo sapiens ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: WDR41 Description of subject: WDR41 is a WD repeat-containing protein implicated in autophagy and lysosomal function, often studied in the context of neurodegenerative disease–related pathways.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.