Celebrex
E474932
Celebrex is a prescription nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as arthritis.
All labels observed (2)
How this entity was disambiguated
This entity first appeared as the object of triple T4850380 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Celebrex Context triple: [Pfizer, developed, Celebrex]
-
A.
Motrin
Motrin is a widely used over-the-counter ibuprofen pain reliever and fever reducer medication.
-
B.
Actopan
Actopan is a municipality and town in the central Mexican state of Hidalgo, known for its colonial architecture, agricultural production, and regional cuisine.
-
C.
Remicade
Remicade is a widely used monoclonal antibody biologic (infliximab) prescribed to treat autoimmune inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
-
D.
Stelara
Stelara is a prescription biologic medication (ustekinumab) used to treat autoimmune conditions such as psoriasis, psoriatic arthritis, and Crohn’s disease by targeting specific immune system pathways.
-
E.
methotrexate
Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat autoimmune conditions such as rheumatoid arthritis, psoriasis, and certain cancers by inhibiting folate-dependent cell proliferation.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Celebrex Target entity description: Celebrex is a prescription nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as arthritis.
-
A.
Motrin
Motrin is a widely used over-the-counter ibuprofen pain reliever and fever reducer medication.
-
B.
Actopan
Actopan is a municipality and town in the central Mexican state of Hidalgo, known for its colonial architecture, agricultural production, and regional cuisine.
-
C.
Remicade
Remicade is a widely used monoclonal antibody biologic (infliximab) prescribed to treat autoimmune inflammatory conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
-
D.
Stelara
Stelara is a prescription biologic medication (ustekinumab) used to treat autoimmune conditions such as psoriasis, psoriatic arthritis, and Crohn’s disease by targeting specific immune system pathways.
-
E.
methotrexate
Methotrexate is a disease-modifying antirheumatic drug (DMARD) commonly used to treat autoimmune conditions such as rheumatoid arthritis, psoriasis, and certain cancers by inhibiting folate-dependent cell proliferation.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
nonsteroidal anti-inflammatory drug
ⓘ
pharmaceutical drug ⓘ prescription medication ⓘ |
| associatedWithRisk |
cardiovascular thrombotic events
ⓘ
gastrointestinal bleeding ⓘ gastrointestinal ulceration ⓘ myocardial infarction ⓘ renal toxicity ⓘ stroke ⓘ |
| belongsToClass | COX-2 selective NSAID ⓘ |
| contraindicatedIn |
patients with aspirin-sensitive asthma triad
ⓘ
patients with history of NSAID-induced asthma ⓘ patients with sulfonamide allergy ⓘ |
| developedBy |
G.D. Searle & Company
ⓘ
linked to:
G. D. Searle & Company
|
| dosageForm | capsule ⓘ |
| eliminationRoute |
fecal
ⓘ
renal ⓘ |
| hasActiveIngredient | celecoxib ⓘ |
| hasGenericName | celecoxib ⓘ |
| hasTradeName | Celebrex ⓘ |
| indicatedFor |
arthritis-associated pain
ⓘ
menstrual pain ⓘ short-term management of acute pain ⓘ |
| legalStatus | prescription-only medicine ⓘ |
| marketedBy | Pfizer ⓘ |
| mayCause |
abdominal pain
ⓘ
diarrhea ⓘ dyspepsia ⓘ edema ⓘ hypertension ⓘ |
| mechanismOfAction | selective COX-2 inhibition ⓘ |
| metabolism | hepatic ⓘ |
| metabolizedBy | CYP2C9 ⓘ |
| onsetOfAction | within a few hours ⓘ |
| pregnancyCategory | may cause fetal risk (late pregnancy) ⓘ |
| reduces | prostaglandin synthesis ⓘ |
| regulatedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
| regulatesEnzyme | cyclooxygenase-2 ⓘ |
| relieves |
inflammation
ⓘ
joint stiffness ⓘ pain ⓘ swelling ⓘ |
| requires | prescription ⓘ |
| routeOfAdministration | oral ⓘ |
| treats |
acute pain
ⓘ
ankylosing spondylitis ⓘ juvenile rheumatoid arthritis ⓘ osteoarthritis ⓘ primary dysmenorrhea ⓘ rheumatoid arthritis ⓘ |
| usedFor | long-term management of arthritis pain ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Celebrex Description of subject: Celebrex is a prescription nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation in conditions such as arthritis.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Celebrex