Isentress
E468958
HIV integrase inhibitor
antiretroviral medication
brand name drug
high-dose formulation of Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Isentress canonical | 1 |
| Isentress HD | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4784890 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Isentress Context triple: [Merck & Co., notableDrug, Isentress]
-
A.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
-
B.
Biktarvy
Biktarvy is a prescription combination antiretroviral medication used to treat HIV-1 infection in adults and certain children.
-
C.
Harvoni
Harvoni is a prescription antiviral medication used to treat chronic hepatitis C virus (HCV) infection.
-
D.
Actemra
Actemra is a prescription biologic medication (tocilizumab) used to treat inflammatory conditions such as rheumatoid arthritis by inhibiting the interleukin-6 (IL-6) receptor.
-
E.
Sovaldi
Sovaldi is a breakthrough antiviral medication used to treat chronic hepatitis C by directly inhibiting the virus’s replication.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Isentress Target entity description: Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
-
A.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
-
B.
Biktarvy
Biktarvy is a prescription combination antiretroviral medication used to treat HIV-1 infection in adults and certain children.
-
C.
Harvoni
Harvoni is a prescription antiviral medication used to treat chronic hepatitis C virus (HCV) infection.
-
D.
Actemra
Actemra is a prescription biologic medication (tocilizumab) used to treat inflammatory conditions such as rheumatoid arthritis by inhibiting the interleukin-6 (IL-6) receptor.
-
E.
Sovaldi
Sovaldi is a breakthrough antiviral medication used to treat chronic hepatitis C by directly inhibiting the virus’s replication.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
HIV integrase inhibitor
ⓘ
antiretroviral medication ⓘ brand name drug ⓘ high-dose formulation of Isentress ⓘ |
| alsoKnownAs | raltegravir ⓘ |
| approvalYear | 2007 ⓘ |
| approvedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
| ATCCode | J05AX08 ⓘ |
| canCauseAdverseEffect |
depression
ⓘ
elevated liver enzymes ⓘ fatigue ⓘ headache ⓘ insomnia ⓘ nausea ⓘ rash ⓘ suicidal ideation ⓘ |
| developedBy | Merck & Co. ⓘ |
| dosageForm |
chewable tablet
ⓘ
film-coated tablet ⓘ oral suspension ⓘ tablet ⓘ |
| eliminationRoute |
feces
ⓘ
urine ⓘ |
| hasActiveIngredient | raltegravir ⓘ |
| hasBlackBoxWarning | no ⓘ |
| hasBrandOwner |
Merck Sharp & Dohme Corp.
ⓘ
linked to:
Merck & Co.
|
| hasContraindication | known hypersensitivity to raltegravir ⓘ |
| hasDrugClass | integrase strand transfer inhibitor ⓘ |
| hasHalfLife | approximately 9 hours ⓘ |
| indicatedFor |
treatment-experienced HIV patients
ⓘ
treatment-naive HIV patients ⓘ use in combination with other antiretroviral agents ⓘ |
| isAvailableAs |
Isentress HD
ⓘ
linked to:
Isentress
|
| isFirstInClass | yes ⓘ |
| isPartOfTherapy | combination antiretroviral therapy ⓘ |
| legalStatusEU | prescription only ⓘ |
| legalStatusUS | prescription only ⓘ |
| mechanismOfAction |
inhibits HIV integrase enzyme
ⓘ
prevents integration of viral DNA into host genome ⓘ |
| metabolism | primarily by UGT1A1-mediated glucuronidation ⓘ |
| pregnancyCategoryUS | C ⓘ |
| routeOfAdministration | oral ⓘ |
| target | HIV-1 integrase ⓘ |
| treats |
HIV infection
ⓘ
HIV-1 infection ⓘ |
| usedIn |
adult patients
ⓘ
pediatric patients ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Isentress Description of subject: Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Isentress