Aldactone
E411215
Aldactone is the brand name for spironolactone, a potassium-sparing diuretic commonly used to treat conditions such as heart failure, hypertension, and fluid retention.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Aldactone canonical | 2 |
| spironolactone | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T4069955 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Aldactone Context triple: [G. D. Searle & Company, notableProduct, Aldactone]
-
A.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
B.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
-
C.
DAViCal
DAViCal is an open-source CalDAV server application used for managing and sharing calendar data over the web.
-
D.
Opekta
Opekta was a German-Dutch company that produced and sold pectin-based gelling agents for making jam, notably managed in its Amsterdam branch by Anne Frank’s father, Otto Frank.
-
E.
Ranelva
Ranelva is a river in Nordland county, Norway, known for flowing through the town of Mo i Rana and into the Ranfjorden.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Aldactone Target entity description: Aldactone is the brand name for spironolactone, a potassium-sparing diuretic commonly used to treat conditions such as heart failure, hypertension, and fluid retention.
-
A.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
B.
Auscitain
An Auscitain is a resident or native of Auch, a historic town in the Occitanie region of southwestern France.
-
C.
DAViCal
DAViCal is an open-source CalDAV server application used for managing and sharing calendar data over the web.
-
D.
Opekta
Opekta was a German-Dutch company that produced and sold pectin-based gelling agents for making jam, notably managed in its Amsterdam branch by Anne Frank’s father, Otto Frank.
-
E.
Ranelva
Ranelva is a river in Nordland county, Norway, known for flowing through the town of Mo i Rana and into the Ranfjorden.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
brand name drug
ⓘ
potassium-sparing diuretic ⓘ |
| blackBoxWarning | tumorigenic in chronic toxicity studies in rats ⓘ |
| commonAdverseEffect |
breast tenderness
ⓘ
fatigue ⓘ gastrointestinal upset ⓘ gynecomastia ⓘ hyperkalemia ⓘ menstrual irregularities ⓘ |
| contraindication |
acute renal insufficiency
ⓘ
anuria ⓘ concomitant use with eplerenone ⓘ hyperkalemia ⓘ significant renal impairment ⓘ |
| dosageForm | tablet ⓘ |
| drugInteraction |
ACE inhibitors (increased risk of hyperkalemia)
ⓘ
ARBs (increased risk of hyperkalemia) ⓘ NSAIDs (reduced diuretic effect) ⓘ other potassium-sparing diuretics ⓘ potassium supplements ⓘ |
| effect |
antihypertensive effect
ⓘ
diuretic effect ⓘ potassium-sparing effect ⓘ |
| hasActiveIngredient |
spironolactone
ⓘ
linked to:
Aldactone
|
| marketedBy |
Pfizer (in many markets)
ⓘ
linked to:
Pfizer
|
| mechanismOfAction |
blocks aldosterone receptors in the distal nephron
ⓘ
decreases potassium excretion ⓘ increases sodium and water excretion ⓘ |
| pharmacologicClass |
aldosterone antagonist
ⓘ
mineralocorticoid receptor antagonist ⓘ |
| pregnancyCategory | use only if clearly needed ⓘ |
| reduces | mortality in certain heart failure patients (with spironolactone) ⓘ |
| regulates |
potassium balance
ⓘ
sodium balance ⓘ |
| routeOfAdministration | oral ⓘ |
| tradeNameOf |
spironolactone
ⓘ
linked to:
Aldactone
|
| usedFor |
acne (off-label)
ⓘ
cirrhotic ascites ⓘ edema ⓘ fluid retention ⓘ heart failure ⓘ hirsutism (off-label) ⓘ hypertension ⓘ hypokalemia prevention ⓘ nephrotic syndrome-associated edema ⓘ polycystic ovary syndrome (off-label) ⓘ primary hyperaldosteronism ⓘ resistant hypertension ⓘ secondary hyperaldosteronism ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Aldactone Description of subject: Aldactone is the brand name for spironolactone, a potassium-sparing diuretic commonly used to treat conditions such as heart failure, hypertension, and fluid retention.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Aldactone
linked to: Aldactone