programmed death-ligand 1

E238185

cell surface glycoprotein immune checkpoint ligand protein

Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein expressed on various cells that suppresses T-cell activity by engaging PD-1, enabling tumors to evade immune surveillance.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (5)

Label	Occurrences
PD-L1	6
programmed death-ligand 1 canonical	3
CD274	1
CD274 gene	1
PDCD1 ligand 1	1

How this entity was disambiguated

This entity first appeared as the object of triple T2138641 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: programmed death-ligand 1
Context triple: [Tecentriq, bindsTo, programmed death-ligand 1]

A. TNF
TNF is a weekly National Football League (NFL) primetime broadcast package featuring games played on Thursday nights during the regular season.
B. PZPR
PZPR was the ruling communist party that governed the Polish People's Republic from the late 1940s until the fall of communism in 1989.
C. CASP13
CASP13 is the 13th Critical Assessment of protein Structure Prediction experiment, an international community-wide competition that benchmarks computational methods for predicting 3D protein structures.
D. TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
E. EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: programmed death-ligand 1
Target entity description: Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein expressed on various cells that suppresses T-cell activity by engaging PD-1, enabling tumors to evade immune surveillance.

A. TNF
TNF is a weekly National Football League (NFL) primetime broadcast package featuring games played on Thursday nights during the regular season.
B. PZPR
PZPR was the ruling communist party that governed the Polish People's Republic from the late 1940s until the fall of communism in 1989.
C. CASP13
CASP13 is the 13th Critical Assessment of protein Structure Prediction experiment, an international community-wide competition that benchmarks computational methods for predicting 3D protein structures.
D. TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
E. EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
F. None of above. chosen

Statements (60)

Predicate	Object
instanceOf	cell surface glycoprotein ⓘ immune checkpoint ligand ⓘ protein ⓘ
associatedWithDisease	Hodgkin lymphoma ⓘ gastric cancer ⓘ head and neck squamous cell carcinoma ⓘ hepatocellular carcinoma ⓘ melanoma ⓘ non-small cell lung cancer ⓘ renal cell carcinoma ⓘ triple-negative breast cancer ⓘ urothelial carcinoma ⓘ
belongsToFamily	B7 family ⓘ
bindsTo	PD-1 ⓘ programmed cell death protein 1 ⓘ
biologicalProcess	immune checkpoint signaling ⓘ inhibition of cytotoxic T lymphocyte function ⓘ negative regulation of T cell activation ⓘ peripheral T cell tolerance ⓘ tumor immune evasion ⓘ
cellularLocation	cell surface ⓘ plasma membrane ⓘ
encodedByGene	CD274 gene ⓘ linked to: programmed death-ligand 1
expressedOn	B cells ⓘ T cells ⓘ antigen-presenting cells ⓘ dendritic cells ⓘ endothelial cells ⓘ epithelial cells ⓘ macrophages ⓘ tumor cells ⓘ
geneOntologyTerm	GO:0031294 ⓘ
hasDomain	cytoplasmic tail ⓘ extracellular IgC-like domain ⓘ extracellular IgV-like domain ⓘ transmembrane domain ⓘ
hasPostTranslationalModification	N-linked glycosylation ⓘ
hasSynonym	B7-H1 ⓘ CD274 ⓘ linked to: programmed death-ligand 1 PD-L1 ⓘ linked to: programmed death-ligand 1 PDCD1 ligand 1 ⓘ linked to: programmed death-ligand 1
inhibits	T cell cytokine production ⓘ T cell cytotoxicity ⓘ T cell proliferation ⓘ
locatedOnChromosome	human chromosome 9p24.1 ⓘ
measuredBy	immunohistochemistry ⓘ
molecularFunction	inhibitory immune receptor ligand ⓘ
organism	Homo sapiens ⓘ
pathway	PD-1 signaling pathway ⓘ
regulates	immune tolerance to self-antigens ⓘ
targetOfDrug	atezolizumab ⓘ avelumab ⓘ durvalumab ⓘ linked to: Imfinzi nivolumab ⓘ pembrolizumab ⓘ linked to: Keytruda
uniprotId	Q9NZQ7 ⓘ
upregulatedBy	inflammatory cytokines ⓘ interferon-gamma ⓘ
usedAsBiomarkerFor	response to PD-1 blockade therapy ⓘ response to PD-L1 blockade therapy ⓘ

How these facts were elicited