programmed death-ligand 1
E238185
Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein expressed on various cells that suppresses T-cell activity by engaging PD-1, enabling tumors to evade immune surveillance.
All labels observed (5)
| Label | Occurrences |
|---|---|
| CD274 | 1 |
| CD274 gene | 1 |
| PD-L1 | 1 |
| PDCD1 ligand 1 | 1 |
| programmed death-ligand 1 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2138641 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: programmed death-ligand 1 Context triple: [Tecentriq, bindsTo, programmed death-ligand 1]
-
A.
TNF
TNF is a weekly National Football League (NFL) primetime broadcast package featuring games played on Thursday nights during the regular season.
-
B.
PZPR
PZPR was the ruling communist party that governed the Polish People's Republic from the late 1940s until the fall of communism in 1989.
-
C.
CASP13
CASP13 is the 13th Critical Assessment of protein Structure Prediction experiment, an international community-wide competition that benchmarks computational methods for predicting 3D protein structures.
-
D.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
E.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: programmed death-ligand 1 Target entity description: Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein expressed on various cells that suppresses T-cell activity by engaging PD-1, enabling tumors to evade immune surveillance.
-
A.
TNF
TNF is a weekly National Football League (NFL) primetime broadcast package featuring games played on Thursday nights during the regular season.
-
B.
PZPR
PZPR was the ruling communist party that governed the Polish People's Republic from the late 1940s until the fall of communism in 1989.
-
C.
CASP13
CASP13 is the 13th Critical Assessment of protein Structure Prediction experiment, an international community-wide competition that benchmarks computational methods for predicting 3D protein structures.
-
D.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
E.
EGF
EGF is the ICAO airline designator used to identify American Eagle Airlines in aviation operations and communications.
- F. None of above. chosen
Statements (60)
| Predicate | Object |
|---|---|
| instanceOf |
cell surface glycoprotein
ⓘ
immune checkpoint ligand ⓘ protein ⓘ |
| associatedWithDisease |
Hodgkin lymphoma
ⓘ
gastric cancer ⓘ head and neck squamous cell carcinoma ⓘ hepatocellular carcinoma ⓘ melanoma ⓘ non-small cell lung cancer ⓘ renal cell carcinoma ⓘ triple-negative breast cancer ⓘ urothelial carcinoma ⓘ |
| belongsToFamily | B7 family ⓘ |
| bindsTo |
PD-1
ⓘ
programmed cell death protein 1 ⓘ |
| biologicalProcess |
immune checkpoint signaling
ⓘ
inhibition of cytotoxic T lymphocyte function ⓘ negative regulation of T cell activation ⓘ peripheral T cell tolerance ⓘ tumor immune evasion ⓘ |
| cellularLocation |
cell surface
ⓘ
plasma membrane ⓘ |
| encodedByGene |
CD274 gene
ⓘ
linked to:
programmed death-ligand 1
|
| expressedOn |
B cells
ⓘ
T cells ⓘ antigen-presenting cells ⓘ dendritic cells ⓘ endothelial cells ⓘ epithelial cells ⓘ macrophages ⓘ tumor cells ⓘ |
| geneOntologyTerm | GO:0031294 ⓘ |
| hasDomain |
cytoplasmic tail
ⓘ
extracellular IgC-like domain ⓘ extracellular IgV-like domain ⓘ transmembrane domain ⓘ |
| hasPostTranslationalModification | N-linked glycosylation ⓘ |
| hasSynonym |
B7-H1
ⓘ
CD274 ⓘ
linked to:
programmed death-ligand 1
PD-L1 ⓘ
linked to:
programmed death-ligand 1
PDCD1 ligand 1 ⓘ
linked to:
programmed death-ligand 1
|
| inhibits |
T cell cytokine production
ⓘ
T cell cytotoxicity ⓘ T cell proliferation ⓘ |
| locatedOnChromosome | human chromosome 9p24.1 ⓘ |
| measuredBy | immunohistochemistry ⓘ |
| molecularFunction | inhibitory immune receptor ligand ⓘ |
| organism | Homo sapiens ⓘ |
| pathway | PD-1 signaling pathway ⓘ |
| regulates | immune tolerance to self-antigens ⓘ |
| targetOfDrug |
atezolizumab
ⓘ
avelumab ⓘ durvalumab ⓘ
linked to:
Imfinzi
nivolumab ⓘ pembrolizumab ⓘ
linked to:
Keytruda
|
| uniprotId | Q9NZQ7 ⓘ |
| upregulatedBy |
inflammatory cytokines
ⓘ
interferon-gamma ⓘ |
| usedAsBiomarkerFor |
response to PD-1 blockade therapy
ⓘ
response to PD-L1 blockade therapy ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: programmed death-ligand 1 Description of subject: Programmed death-ligand 1 (PD-L1) is an immune checkpoint protein expressed on various cells that suppresses T-cell activity by engaging PD-1, enabling tumors to evade immune surveillance.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: programmed death-ligand 1
linked to: programmed death-ligand 1
linked to: programmed death-ligand 1
linked to: programmed death-ligand 1