SeeDB
E902753
SeeDB is a tissue-clearing method that uses high-concentration fructose solutions to render biological samples optically transparent while preserving their structural integrity for deep imaging.
All labels observed (2)
How this entity was disambiguated
This entity first appeared as the object of triple T11057953 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: SeeDB Context triple: [Scale tissue clearing method, comparedWith, SeeDB]
-
A.
Questel
Questel is the surname of Mae Questel, the American actress best known as the original voice of Betty Boop and Olive Oyl.
-
B.
IsDB
IsDB is the Islamic Development Bank, a multilateral development finance institution that supports economic and social progress in member countries in accordance with Islamic principles.
-
C.
ERDB
ERDB is a Philippine government bureau focused on conducting research and development to support the sustainable management and conservation of the country’s ecosystems and natural resources.
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D.
SDB
SDB is the post-nominal abbreviation used by members of the Salesians of Don Bosco, a Roman Catholic religious institute dedicated especially to the education and evangelization of youth.
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E.
ESearch
ESearch is an NCBI E-utilities service that performs text-based searches of NCBI databases and returns lists of matching record identifiers.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: SeeDB Target entity description: SeeDB is a tissue-clearing method that uses high-concentration fructose solutions to render biological samples optically transparent while preserving their structural integrity for deep imaging.
-
A.
Questel
Questel is the surname of Mae Questel, the American actress best known as the original voice of Betty Boop and Olive Oyl.
-
B.
IsDB
IsDB is the Islamic Development Bank, a multilateral development finance institution that supports economic and social progress in member countries in accordance with Islamic principles.
-
C.
ERDB
ERDB is a Philippine government bureau focused on conducting research and development to support the sustainable management and conservation of the country’s ecosystems and natural resources.
-
D.
SDB
SDB is the post-nominal abbreviation used by members of the Salesians of Don Bosco, a Roman Catholic religious institute dedicated especially to the education and evangelization of youth.
-
E.
ESearch
ESearch is an NCBI E-utilities service that performs text-based searches of NCBI databases and returns lists of matching record identifiers.
- F. None of above. chosen
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
optical clearing technique
ⓘ
tissue-clearing method ⓘ |
| advantageOverSolventMethods |
better preservation of fluorescence
ⓘ
reduced tissue shrinkage ⓘ |
| aimsTo |
enable deep imaging
ⓘ
render biological samples optically transparent ⓘ |
| appliesTo |
brain tissue
ⓘ
fixed tissue samples ⓘ mouse brain ⓘ |
| clearingMechanism |
reduction of light scattering
ⓘ
refractive index matching ⓘ |
| compatibleWith |
confocal microscopy
ⓘ
light-sheet fluorescence microscopy ⓘ two-photon microscopy ⓘ |
| developedBy | Takeshi Ke and colleagues ⓘ |
| doesNotUse |
detergent-based lipid removal
ⓘ
organic solvents ⓘ |
| field |
bioimaging
ⓘ
neuroscience ⓘ tissue engineering ⓘ |
| finalRefractiveIndex | approximately 1.49 ⓘ |
| hasProperty |
aqueous
ⓘ
high refractive index ⓘ mild clearing conditions ⓘ preserves fluorescence signals ⓘ preserves tissue morphology ⓘ |
| hasVariant |
SeeDB2
ⓘ
linked to:
SeeDB
|
| optimizedFor |
maintaining sample size
ⓘ
minimizing tissue deformation ⓘ |
| preserves |
fine neural structures
ⓘ
structural integrity of tissue ⓘ |
| publicationYear | 2013 ⓘ |
| publishedIn | Nature Neuroscience ⓘ |
| relatedTo |
CLARITY
ⓘ
CUBIC ⓘ Scale ⓘ |
| requires | stepwise increase of fructose concentration ⓘ |
| samplePreparation | fixed tissue ⓘ |
| speciesPrimarilyTestedOn | mouse ⓘ |
| usedFor |
3D reconstruction of neural circuits
ⓘ
visualization of fluorescently labeled cells ⓘ whole-brain imaging ⓘ |
| usesReagent |
high-concentration fructose solution
ⓘ
thioglycerol ⓘ water ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: SeeDB Description of subject: SeeDB is a tissue-clearing method that uses high-concentration fructose solutions to render biological samples optically transparent while preserving their structural integrity for deep imaging.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: SeeDB