Gi-coupled GPCR
E874315
A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Gi-coupled GPCR canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10610018 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Gi-coupled GPCR Context triple: [Gi protein, couplesToReceptor, Gi-coupled GPCR]
-
A.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
B.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
C.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
D.
GABA
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, crucial for reducing neuronal excitability and regulating muscle tone and anxiety.
-
E.
NMDA receptor
The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Gi-coupled GPCR Target entity description: A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
-
A.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
-
B.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
C.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
D.
GABA
GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system, crucial for reducing neuronal excitability and regulating muscle tone and anxiety.
-
E.
NMDA receptor
The NMDA receptor is a glutamate-activated ion channel in the brain that plays a key role in synaptic plasticity, learning, and memory, and is implicated in various neurological and psychiatric disorders.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
G protein–coupled receptor
ⓘ
membrane receptor ⓘ |
| activates |
Gi alpha subunit
ⓘ
Gi beta-gamma subunits ⓘ |
| associatedWith |
cancer
ⓘ
cardiovascular diseases ⓘ metabolic disorders ⓘ neurological disorders ⓘ |
| belongsToFamily | class A GPCR ⓘ |
| canActivate |
MAPK signaling pathway
ⓘ
PI3K-Akt signaling pathway ⓘ |
| canAlsoSignalVia | beta-arrestin–dependent pathways ⓘ |
| couplesTo |
Gi protein
ⓘ
heterotrimeric G protein ⓘ |
| downstreamEffect |
modulation of ion channel activity
ⓘ
reduced protein kinase A activity ⓘ regulation of gene transcription ⓘ |
| encodedBy | GPCR genes ⓘ |
| example |
D2 dopamine receptor
ⓘ
linked to:
dopamine D2 receptor
M2 muscarinic acetylcholine receptor ⓘ alpha2-adrenergic receptor ⓘ chemokine receptor CCR5 ⓘ chemokine receptor CXCR4 ⓘ
linked to:
CXCR4
opioid receptor ⓘ somatostatin receptor ⓘ |
| foundIn |
invertebrates
ⓘ
vertebrates ⓘ |
| hasEffectOn |
adenylyl cyclase inhibition
ⓘ
decrease in intracellular cAMP levels ⓘ |
| hasStructuralFeature | seven transmembrane helices ⓘ |
| involvedIn |
cardiovascular regulation
ⓘ
endocrine regulation ⓘ immune cell trafficking ⓘ neurotransmission ⓘ |
| isTargetOf | many therapeutic drugs ⓘ |
| ligandType |
chemokine
ⓘ
hormone ⓘ lipid mediator ⓘ neurotransmitter ⓘ |
| locatedIn | plasma membrane ⓘ |
| negativelyRegulates | cAMP production ⓘ |
| regulates | adenylyl cyclase activity ⓘ |
| requires | agonist binding for activation ⓘ |
| signalTransductionMechanism | G protein–dependent signaling ⓘ |
| subjectTo |
desensitization
ⓘ
downregulation ⓘ internalization ⓘ |
| undergoes | conformational change upon ligand binding ⓘ |
| uponActivation |
dissociates Gi alpha from beta-gamma complex
ⓘ
promotes GDP-GTP exchange on Gi alpha subunit ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Gi-coupled GPCR Description of subject: A Gi-coupled GPCR is a G protein–coupled receptor that, upon activation, inhibits adenylyl cyclase and decreases intracellular cAMP levels through coupling to Gi proteins.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.