danazol
E850019
Danazol is a synthetic androgen used primarily to treat endometriosis, fibrocystic breast disease, and hereditary angioedema.
All labels observed (1)
| Label | Occurrences |
|---|---|
| danazol canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10214860 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: danazol Context triple: [CYP2J2, inhibitedBy, danazol]
-
A.
Giprostal
Giprostal was a prominent Soviet-era design institute specializing in the planning and engineering of metallurgical and industrial facilities.
-
B.
Lethenteron
Lethenteron is a genus of jawless, eel-like lampreys found primarily in freshwater and coastal regions of the Northern Hemisphere.
-
C.
Pregny-Chambésy
Pregny-Chambésy is a small, affluent municipality on the shores of Lake Geneva in the canton of Geneva, Switzerland, known for hosting several international organizations and diplomatic missions.
-
D.
Enovid
Enovid was the first commercially available oral contraceptive pill, introduced in the 1960s and widely recognized for revolutionizing birth control and reproductive health.
-
E.
Panazol
Panazol is a suburban commune in west-central France, located just east of the city of Limoges in the Nouvelle-Aquitaine region.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: danazol Target entity description: Danazol is a synthetic androgen used primarily to treat endometriosis, fibrocystic breast disease, and hereditary angioedema.
-
A.
Giprostal
Giprostal was a prominent Soviet-era design institute specializing in the planning and engineering of metallurgical and industrial facilities.
-
B.
Lethenteron
Lethenteron is a genus of jawless, eel-like lampreys found primarily in freshwater and coastal regions of the Northern Hemisphere.
-
C.
Pregny-Chambésy
Pregny-Chambésy is a small, affluent municipality on the shores of Lake Geneva in the canton of Geneva, Switzerland, known for hosting several international organizations and diplomatic missions.
-
D.
Enovid
Enovid was the first commercially available oral contraceptive pill, introduced in the 1960s and widely recognized for revolutionizing birth control and reproductive health.
-
E.
Panazol
Panazol is a suburban commune in west-central France, located just east of the city of Limoges in the Nouvelle-Aquitaine region.
- F. None of above. chosen
Statements (58)
| Predicate | Object |
|---|---|
| instanceOf |
medication
ⓘ
small molecule ⓘ steroidal drug ⓘ synthetic androgen ⓘ |
| affectsSystem |
endocrine system
ⓘ
hepatic system ⓘ reproductive system ⓘ |
| contraindicatedIn |
breastfeeding
ⓘ
porphyria ⓘ pregnancy ⓘ severe cardiac disease ⓘ severe hepatic impairment ⓘ severe renal impairment ⓘ |
| hasAdverseEffect |
acne
ⓘ
decreased breast size ⓘ elevated liver enzymes ⓘ headache ⓘ hirsutism ⓘ hot flashes ⓘ hyperlipidemia ⓘ menstrual irregularities ⓘ mood changes ⓘ oily skin ⓘ thromboembolic events ⓘ voice deepening ⓘ weight gain ⓘ |
| hasATCCode | G03XA01 ⓘ |
| hasBioavailability | variable oral bioavailability ⓘ |
| hasCASNumber | 17230-88-5 ⓘ |
| hasChemicalFormula | C22H27NO2 ⓘ |
| hasDrugBankID | DB01260 ⓘ |
| hasHalfLife | approximately 24 hours ⓘ |
| hasIUPACName | (1S,10S,11S,14S,15S)-14-ethyl-14-hydroxy-3-oxo-2,3,4,7,8,9,10,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-17-carbonitrile ⓘ |
| hasMechanismOfAction |
binding to sex hormone-binding globulin
ⓘ
increase of C1 esterase inhibitor levels ⓘ inhibition of mid-cycle surge of luteinizing hormone ⓘ reduction of estrogen production ⓘ suppression of pituitary gonadotropin secretion ⓘ weak androgen receptor agonism ⓘ |
| hasMolarMass | 337.46 g/mol ⓘ |
| hasPharmacologicalClass |
androgen
ⓘ
antigonadotropin ⓘ gonadotropin-release inhibitor ⓘ |
| hasPregnancyCategory | X (US) ⓘ |
| hasPubChemCID | 2956 ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| hasUNII | 9AYD343T1E ⓘ |
| isAdministeredAs | oral capsule ⓘ |
| isDerivativeOf | ethisterone ⓘ |
| isEliminatedVia |
feces
ⓘ
urine ⓘ |
| isMetabolizedIn | liver ⓘ |
| isTeratogenic | true ⓘ |
| usedFor |
endometriosis
ⓘ
fibrocystic breast disease ⓘ hereditary angioedema ⓘ menorrhagia associated with uterine fibroids ⓘ prevention of angioedema attacks in hereditary angioedema ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: danazol Description of subject: Danazol is a synthetic androgen used primarily to treat endometriosis, fibrocystic breast disease, and hereditary angioedema.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.