Simponi
E850003
Simponi is a prescription biologic medication (golimumab) used to treat autoimmune inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis by blocking tumor necrosis factor (TNF).
All labels observed (2)
| Label | Occurrences |
|---|---|
| Simponi canonical | 3 |
| Simponi Aria | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10214519 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Simponi Context triple: [Janssen Biotech, product, Simponi]
-
A.
Sipson
Sipson is a village in the London Borough of Hillingdon, England, located close to Heathrow Airport and known for its involvement in debates over airport expansion.
-
B.
Simpson
Simpson is a common English-language surname borne by numerous notable individuals across fields such as science, politics, sports, and entertainment.
-
C.
Simbo
Simbo is an Oceanic language of the Meso-Melanesian subgroup spoken on Simbo Island in the Solomon Islands.
-
D.
Simm
Simm is an English surname most notably associated with actor John Simm, known for his roles in British television and film.
-
E.
Symon
Symon is a given name most notably borne by Symon Petliura, a Ukrainian political leader and statesman of the early 20th century.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Simponi Target entity description: Simponi is a prescription biologic medication (golimumab) used to treat autoimmune inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis by blocking tumor necrosis factor (TNF).
-
A.
Sipson
Sipson is a village in the London Borough of Hillingdon, England, located close to Heathrow Airport and known for its involvement in debates over airport expansion.
-
B.
Simpson
Simpson is a common English-language surname borne by numerous notable individuals across fields such as science, politics, sports, and entertainment.
-
C.
Simbo
Simbo is an Oceanic language of the Meso-Melanesian subgroup spoken on Simbo Island in the Solomon Islands.
-
D.
Simm
Simm is an English surname most notably associated with actor John Simm, known for his roles in British television and film.
-
E.
Symon
Symon is a given name most notably borne by Symon Petliura, a Ukrainian political leader and statesman of the early 20th century.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
biologic medication
ⓘ
brand name drug ⓘ tumor necrosis factor inhibitor ⓘ |
| administrationFrequency | once monthly for subcutaneous formulation ⓘ |
| approvalBy |
European Medicines Agency
ⓘ
U.S. Food and Drug Administration ⓘ
linked to:
Food and Drug Administration
|
| combinationTherapyWith | methotrexate ⓘ |
| commonAdverseEffect |
headache
ⓘ
injection site reaction ⓘ upper respiratory tract infection ⓘ |
| contraindication |
history of hypersensitivity to golimumab
ⓘ
severe active infections ⓘ |
| developer | Janssen Biotech ⓘ |
| drugClass |
TNF inhibitor
ⓘ
biologic disease-modifying antirheumatic drug ⓘ monoclonal antibody ⓘ |
| firstFDAApprovalYear | 2009 ⓘ |
| formulation |
autoinjector pen
ⓘ
intravenous infusion solution ⓘ prefilled syringe ⓘ |
| hasActiveIngredient | golimumab ⓘ |
| hasATCCode | L04AB06 ⓘ |
| hasBlackBoxWarning |
malignancy risk
ⓘ
serious infections ⓘ |
| indicatedFor |
active ankylosing spondylitis
ⓘ
active psoriatic arthritis ⓘ moderate to severe active rheumatoid arthritis ⓘ moderately to severely active ulcerative colitis ⓘ |
| legalStatusEU | prescription only ⓘ |
| legalStatusUS | prescription only ⓘ |
| manufacturer | Janssen Biotech ⓘ |
| marketingAuthorizationHolder | Janssen Biotech ⓘ |
| mechanismOfAction | tumor necrosis factor alpha blockade ⓘ |
| ownedBy | Johnson & Johnson ⓘ |
| pregnancyCategoryUS | B ⓘ |
| regulatoryStatus | prescription only ⓘ |
| requires | prescription ⓘ |
| routeOfAdministration |
intravenous infusion
ⓘ
subcutaneous injection ⓘ |
| seriousAdverseEffect |
congestive heart failure exacerbation
ⓘ
hepatitis B reactivation ⓘ opportunistic infections ⓘ tuberculosis ⓘ |
| targets | tumor necrosis factor alpha ⓘ |
| treats |
ankylosing spondylitis
ⓘ
non-radiographic axial spondyloarthritis ⓘ psoriatic arthritis ⓘ rheumatoid arthritis ⓘ ulcerative colitis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Simponi Description of subject: Simponi is a prescription biologic medication (golimumab) used to treat autoimmune inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis by blocking tumor necrosis factor (TNF).
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Simponi