Symmetrel
E804596
Symmetrel is a brand-name antiviral and antiparkinsonian medication whose active ingredient is amantadine.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Symmetrel canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9524839 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Symmetrel Context triple: [amantadine, hasBrandName, Symmetrel]
-
A.
Acurenam
Acurenam is a town located in the Centro Sur province of Equatorial Guinea.
-
B.
Namenda
Namenda is a prescription medication used to treat moderate to severe Alzheimer's disease by regulating the activity of glutamate in the brain.
-
C.
Donepezil
Donepezil is a cholinesterase inhibitor medication primarily used to treat cognitive symptoms of Alzheimer's disease.
-
D.
Rinvoq
Rinvoq is a prescription JAK inhibitor medication used to treat various inflammatory and autoimmune conditions such as rheumatoid arthritis and atopic dermatitis.
-
E.
rivastigmine
Rivastigmine is a cholinesterase inhibitor medication used to manage symptoms of mild to moderate dementia, particularly in Alzheimer's and Parkinson's disease.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Symmetrel Target entity description: Symmetrel is a brand-name antiviral and antiparkinsonian medication whose active ingredient is amantadine.
-
A.
Acurenam
Acurenam is a town located in the Centro Sur province of Equatorial Guinea.
-
B.
Namenda
Namenda is a prescription medication used to treat moderate to severe Alzheimer's disease by regulating the activity of glutamate in the brain.
-
C.
Donepezil
Donepezil is a cholinesterase inhibitor medication primarily used to treat cognitive symptoms of Alzheimer's disease.
-
D.
Rinvoq
Rinvoq is a prescription JAK inhibitor medication used to treat various inflammatory and autoimmune conditions such as rheumatoid arthritis and atopic dermatitis.
-
E.
rivastigmine
Rivastigmine is a cholinesterase inhibitor medication used to manage symptoms of mild to moderate dementia, particularly in Alzheimer's and Parkinson's disease.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
antiparkinsonian medication
ⓘ
antiviral medication ⓘ brand-name drug ⓘ |
| belongsTo | human prescription drug ⓘ |
| contraindicatedIn |
known hypersensitivity to amantadine
ⓘ
severe renal impairment without dose adjustment ⓘ |
| developedFrom | amantadine hydrochloride ⓘ |
| hasActiveIngredient | amantadine ⓘ |
| hasAdverseEffect |
confusion
ⓘ
dizziness ⓘ hallucinations ⓘ insomnia ⓘ livedo reticularis ⓘ nausea ⓘ peripheral edema ⓘ |
| hasATCCode |
J05BB01
ⓘ
N04BB01 ⓘ |
| hasChemicalSubstance |
amantadine hydrochloride
ⓘ
linked to:
amantadine
|
| hasDosageForm |
capsule
ⓘ
oral solution ⓘ |
| hasEffect |
reduces Parkinsonian bradykinesia
ⓘ
reduces Parkinsonian rigidity ⓘ reduces levodopa-induced dyskinesia ⓘ |
| hasLegalStatus | prescription-only medicine in many countries ⓘ |
| hasMechanismOfAction |
blocks dopamine reuptake
ⓘ
blocks influenza A M2 ion channel ⓘ increases dopamine release in the central nervous system ⓘ |
| hasOriginCountry |
United States
ⓘ
linked to:
United States of America
|
| hasPharmacologicClass |
adamantane antiviral
ⓘ
dopaminergic agent ⓘ |
| hasPregnancyCategory | C (US, historical) ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| laterApprovedFor |
treatment of Parkinson's disease
ⓘ
treatment of drug-induced extrapyramidal reactions ⓘ |
| mayCause |
anticholinergic-like side effects
ⓘ
impulse control disorders ⓘ orthostatic hypotension ⓘ |
| metabolizedBy | kidney excretion ⓘ |
| requiresCautionIn |
elderly patients
ⓘ
patients with congestive heart failure ⓘ patients with psychiatric disorders ⓘ patients with seizure disorders ⓘ |
| tradeNameOf | amantadine ⓘ |
| usedAs | adjunct therapy in Parkinson's disease ⓘ |
| usedFor |
treatment of Parkinson's disease
ⓘ
treatment of drug-induced extrapyramidal symptoms ⓘ treatment of influenza A infection ⓘ |
| wasFirstApprovedFor | prophylaxis and treatment of influenza A ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Symmetrel Description of subject: Symmetrel is a brand-name antiviral and antiparkinsonian medication whose active ingredient is amantadine.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.