progressive supranuclear palsy
E804589
Progressive supranuclear palsy is a rare neurodegenerative movement disorder characterized by early postural instability, vertical gaze palsy, and cognitive and behavioral changes due to widespread tau pathology in the brain.
All labels observed (1)
| Label | Occurrences |
|---|---|
| progressive supranuclear palsy canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T9524726 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: progressive supranuclear palsy Context triple: [substantia nigra, pathologyAssociatedWith, progressive supranuclear palsy]
-
A.
Lewy body dementia
Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.
-
B.
Parkinson
"Parkinson" is a long-running British television talk show hosted by journalist and broadcaster Michael Parkinson, renowned for its in-depth celebrity interviews.
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C.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
-
D.
PD
PD is the commonly used abbreviation for Italy’s center-left political party, the Partito Democratico (Democratic Party).
-
E.
ALS
ALS is the abbreviation for the Army Legal Services Branch, the specialist legal branch of the British Army responsible for providing legal support and advice.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: progressive supranuclear palsy Target entity description: Progressive supranuclear palsy is a rare neurodegenerative movement disorder characterized by early postural instability, vertical gaze palsy, and cognitive and behavioral changes due to widespread tau pathology in the brain.
-
A.
Lewy body dementia
Lewy body dementia is a progressive neurodegenerative disorder characterized by cognitive decline, visual hallucinations, fluctuating alertness, and Parkinsonian movement symptoms, caused by abnormal protein deposits called Lewy bodies in the brain.
-
B.
Parkinson
"Parkinson" is a long-running British television talk show hosted by journalist and broadcaster Michael Parkinson, renowned for its in-depth celebrity interviews.
-
C.
Parkinson's disease
Parkinson's disease is a progressive neurodegenerative disorder characterized primarily by motor symptoms such as tremors, rigidity, and slowed movement, caused by the loss of dopamine-producing neurons in the brain.
-
D.
PD
PD is the commonly used abbreviation for Italy’s center-left political party, the Partito Democratico (Democratic Party).
-
E.
ALS
ALS is the abbreviation for the Army Legal Services Branch, the specialist legal branch of the British Army responsible for providing legal support and advice.
- F. None of above. chosen
Statements (58)
| Predicate | Object |
|---|---|
| instanceOf |
movement disorder
ⓘ
neurodegenerative disease ⓘ tauopathy ⓘ |
| affectsAnatomicalStructure |
basal ganglia
ⓘ
brainstem ⓘ frontal cortex ⓘ
linked to:
prefrontal cortex
globus pallidus ⓘ substantia nigra ⓘ subthalamic nucleus ⓘ |
| hasAbbreviation | PSP ⓘ |
| hasCause | abnormal tau metabolism ⓘ |
| hasCourse | progressive ⓘ |
| hasDiagnosticTool |
brain MRI
ⓘ
clinical examination ⓘ functional imaging (e.g., PET, SPECT) ⓘ |
| hasEpidemiology | rare worldwide ⓘ |
| hasMedianSurvival | approximately 6 to 10 years from symptom onset ⓘ |
| hasNoCure | true ⓘ |
| hasOnset | late adulthood ⓘ |
| hasPathology |
4R tauopathy
ⓘ
gliosis ⓘ neurofibrillary tangles ⓘ neuronal loss ⓘ tau protein aggregation ⓘ |
| hasPrognosis | poor ⓘ |
| hasRiskFactor |
genetic susceptibility
ⓘ
older age ⓘ |
| hasSexPredominance | slight male predominance ⓘ |
| hasSymptom |
apathy
ⓘ
axial rigidity ⓘ behavioral changes ⓘ bradykinesia ⓘ cognitive impairment ⓘ dysarthria ⓘ dysphagia ⓘ dystonia ⓘ early falls ⓘ executive dysfunction ⓘ frontal lobe syndrome ⓘ gait freezing ⓘ neck extension (retrocollis) ⓘ postural instability ⓘ pseudobulbar affect ⓘ sleep disturbances ⓘ supranuclear ophthalmoplegia ⓘ vertical gaze palsy ⓘ |
| hasTreatment |
occupational therapy
ⓘ
physiotherapy ⓘ speech therapy ⓘ supportive care ⓘ symptomatic pharmacologic therapy ⓘ |
| hasTypicalAgeOfOnset | 60s ⓘ |
| isCharacterizedBy |
early postural instability
ⓘ
frontal cognitive and behavioral changes ⓘ vertical supranuclear gaze palsy ⓘ |
| isOftenMisdiagnosedAs |
Parkinson's disease
ⓘ
atypical parkinsonism ⓘ |
| medicalCondition | rare disease ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: progressive supranuclear palsy Description of subject: Progressive supranuclear palsy is a rare neurodegenerative movement disorder characterized by early postural instability, vertical gaze palsy, and cognitive and behavioral changes due to widespread tau pathology in the brain.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.