essential amino acid tryptophan
E77872
Essential amino acid tryptophan is a vital nutrient that humans must obtain from their diet and that serves as a biochemical precursor to important molecules such as serotonin, melatonin, and niacin.
All labels observed (1)
| Label | Occurrences |
|---|---|
| essential amino acid tryptophan canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T623454 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: essential amino acid tryptophan Context triple: [Frederick Gowland Hopkins, discovered, essential amino acid tryptophan]
-
A.
Malate
Malate is a historic coastal district of Manila, Philippines, known for its nightlife, cultural landmarks, and proximity to Manila Bay.
-
B.
Behring
Behring is a German surname most notably associated with Emil Adolf von Behring, the pioneering physiologist and first Nobel laureate in Physiology or Medicine for his work on serum therapy.
-
C.
Avegno
Avegno is a French-origin surname notably borne by Virginie Amélie Avegno Gautreau, the socialite immortalized in John Singer Sargent’s famous portrait "Madame X."
-
D.
Chía
Chía is a municipality in the department of Cundinamarca, Colombia, known for its rapid urban growth and proximity to the capital city, Bogotá.
-
E.
Annex 4 Nutrients
Annex 4 Nutrients is a component of the Great Lakes Water Quality Agreement that sets out binational commitments and strategies to control nutrient pollution and reduce problems like algal blooms in the Great Lakes.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: essential amino acid tryptophan Target entity description: Essential amino acid tryptophan is a vital nutrient that humans must obtain from their diet and that serves as a biochemical precursor to important molecules such as serotonin, melatonin, and niacin.
-
A.
Malate
Malate is a historic coastal district of Manila, Philippines, known for its nightlife, cultural landmarks, and proximity to Manila Bay.
-
B.
Behring
Behring is a German surname most notably associated with Emil Adolf von Behring, the pioneering physiologist and first Nobel laureate in Physiology or Medicine for his work on serum therapy.
-
C.
Avegno
Avegno is a French-origin surname notably borne by Virginie Amélie Avegno Gautreau, the socialite immortalized in John Singer Sargent’s famous portrait "Madame X."
-
D.
Chía
Chía is a municipality in the department of Cundinamarca, Colombia, known for its rapid urban growth and proximity to the capital city, Bogotá.
-
E.
Annex 4 Nutrients
Annex 4 Nutrients is a component of the Great Lakes Water Quality Agreement that sets out binational commitments and strategies to control nutrient pollution and reduce problems like algal blooms in the Great Lakes.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
aromatic amino acid
ⓘ
essential amino acid ⓘ proteinogenic amino acid ⓘ α-amino acid ⓘ |
| absorbsUVLightAt | 280 nm ⓘ |
| affects |
mood regulation via serotonin
ⓘ
sleep-wake cycle via melatonin ⓘ |
| belongsToBiosyntheticFamily | shikimate pathway in microorganisms and plants ⓘ |
| cannotBeSynthesizedBy | humans ⓘ |
| chemicalFormula | C11H12N2O2 ⓘ |
| contributesTo | protein synthesis ⓘ |
| hasAromaticRing | indole ring ⓘ |
| hasChirality | L-configuration in proteins ⓘ |
| hasIUPACName | (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid ⓘ |
| hasOneLetterCode | W ⓘ |
| haspKa |
approximately 2.4 for the carboxyl group
ⓘ
approximately 9.4 for the amino group ⓘ |
| hasSideChain | indole group ⓘ |
| hasStandardGeneticCodeNumber | amino acid number 11 in many lists ⓘ |
| hasThreeLetterCode | Trp ⓘ |
| isAbundantInFood |
cheese
ⓘ
chicken ⓘ eggs ⓘ fish ⓘ milk ⓘ nuts ⓘ seeds ⓘ soybeans ⓘ turkey ⓘ |
| isEncodedByCodon | UGG ⓘ |
| isEssentialFor |
humans
ⓘ
many animals ⓘ |
| isFoundIn | dietary proteins ⓘ |
| isHydrophobic | true ⓘ |
| isMetabolizedPrimarilyIn | liver ⓘ |
| isPrecursorOf |
NAD+
ⓘ
NADP+ ⓘ kynurenine ⓘ melatonin ⓘ niacin ⓘ serotonin ⓘ tryptamine ⓘ |
| mustBeObtainedFrom | diet ⓘ |
| participatesInPathway |
NAD+ biosynthesis
ⓘ
kynurenine pathway ⓘ melatonin biosynthesis ⓘ serotonin biosynthesis ⓘ |
| wasFirstIsolatedBy |
Frederick Hopkins
ⓘ
linked to:
Sir Frederick Gowland Hopkins
|
| wasFirstIsolatedInYear | 1901 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: essential amino acid tryptophan Description of subject: Essential amino acid tryptophan is a vital nutrient that humans must obtain from their diet and that serves as a biochemical precursor to important molecules such as serotonin, melatonin, and niacin.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
Sir Frederick Gowland Hopkins