HD
E730389
HD is an inherited neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms caused by a CAG repeat expansion in the huntingtin gene.
All labels observed (1)
| Label | Occurrences |
|---|---|
| HD canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T8372286 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: HD Context triple: [Huntington's chorea, hasSynonym, HD]
-
A.
HD
HD is the New York Stock Exchange ticker symbol for The Home Depot, the largest home improvement retail chain in the United States.
-
B.
HD
HD is the vehicle registration code used for the German city of Heidelberg.
-
C.
HD
HD is the standard astronomical abbreviation for the Henry Draper Catalogue, a widely used star catalog that assigns spectral classifications and identifiers to hundreds of thousands of stars.
-
D.
HDR
HDR is the commonly used abbreviation for the United Nations Development Programme’s annual Human Development Report, which assesses global progress in human development beyond economic growth alone.
-
E.
HDTV
HDTV (High-Definition Television) is a television broadcasting standard that delivers significantly higher resolution, improved picture clarity, and better color quality compared to traditional standard-definition TV.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: HD Target entity description: HD is an inherited neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms caused by a CAG repeat expansion in the huntingtin gene.
-
A.
HD
HD is the New York Stock Exchange ticker symbol for The Home Depot, the largest home improvement retail chain in the United States.
-
B.
HD
HD is the vehicle registration code used for the German city of Heidelberg.
-
C.
HD
HD is the standard astronomical abbreviation for the Henry Draper Catalogue, a widely used star catalog that assigns spectral classifications and identifiers to hundreds of thousands of stars.
-
D.
HDR
HDR is the commonly used abbreviation for the United Nations Development Programme’s annual Human Development Report, which assesses global progress in human development beyond economic growth alone.
-
E.
HDTV
HDTV (High-Definition Television) is a television broadcasting standard that delivers significantly higher resolution, improved picture clarity, and better color quality compared to traditional standard-definition TV.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
autosomal dominant disease
ⓘ
inherited disorder ⓘ neurodegenerative disease ⓘ |
| affectsChromosome | chromosome 4 ⓘ |
| affectsGene | HTT ⓘ |
| affectsRegion | basal ganglia ⓘ |
| affectsSystem | central nervous system ⓘ |
| hasAbbreviation | HD ⓘ |
| hasBiomarker | expanded CAG repeat number in HTT ⓘ |
| hasCategory |
movement disorder
ⓘ
neurogenetic disorder ⓘ trinucleotide repeat disorder ⓘ |
| hasCause |
CAG trinucleotide repeat expansion in the HTT gene
ⓘ
expanded CAG repeat in the huntingtin gene ⓘ |
| hasCure | no known cure ⓘ |
| hasDiagnosticTest | molecular genetic testing of HTT CAG repeat length ⓘ |
| hasEponym | George Huntington ⓘ |
| hasFeature | genetic anticipation with earlier onset in successive generations ⓘ |
| hasGeneticMechanism | CAG repeat expansion above normal threshold ⓘ |
| hasManagement | multidisciplinary care ⓘ |
| hasModeOfTransmission | vertical transmission ⓘ |
| hasOnset | usually in mid-adulthood ⓘ |
| hasPathogenesis | toxic gain of function of mutant huntingtin protein ⓘ |
| hasPathology |
neurodegeneration of caudate nucleus
ⓘ
neurodegeneration of putamen ⓘ neurodegeneration of striatum ⓘ |
| hasPenetrance | high penetrance ⓘ |
| hasPrognosis | progressive and ultimately fatal ⓘ |
| hasPsychiatricComponent | true ⓘ |
| hasRiskFactor | family history of Huntington's disease ⓘ |
| hasSymptom |
apathy
ⓘ
chorea ⓘ cognitive decline ⓘ dementia ⓘ depression ⓘ dystonia ⓘ gait disturbance ⓘ impaired voluntary movements ⓘ irritability ⓘ obsessive-compulsive symptoms ⓘ progressive motor dysfunction ⓘ psychiatric symptoms ⓘ psychosis ⓘ |
| hasTreatment | symptomatic treatment only ⓘ |
| hasTypicalCourse | gradual progression over 10 to 25 years ⓘ |
| hasVariant |
juvenile-onset Huntington's disease
ⓘ
linked to:
Huntington's chorea
|
| inheritancePattern | autosomal dominant ⓘ |
| isMonogenic | true ⓘ |
| showsAnticipation | true ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: HD Description of subject: HD is an inherited neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric symptoms caused by a CAG repeat expansion in the huntingtin gene.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
HD