nearly neutral theory of molecular evolution
E612270
The nearly neutral theory of molecular evolution is an extension of neutral theory that posits most evolutionary changes at the molecular level are due to mutations with very slight deleterious or advantageous effects whose fate is strongly influenced by genetic drift and population size.
All labels observed (2)
| Label | Occurrences |
|---|---|
| nearly neutral theory of molecular evolution canonical | 5 |
| nearly neutral theory | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6683316 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: nearly neutral theory of molecular evolution Context triple: [Motoo Kimura, theoryProposed, nearly neutral theory of molecular evolution]
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A.
Motoo Kimura's neutral theory of molecular evolution
Motoo Kimura's neutral theory of molecular evolution is a foundational concept in evolutionary biology proposing that most genetic variation and molecular changes are selectively neutral and shaped primarily by random genetic drift rather than natural selection.
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B.
neutral theory of population genetics
The neutral theory of population genetics is an evolutionary framework proposing that most genetic variation and molecular changes in populations are governed by random genetic drift of selectively neutral mutations rather than by natural selection.
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C.
Unified Neutral Theory of Biodiversity and Biogeography
Unified Neutral Theory of Biodiversity and Biogeography is an influential ecological theory proposing that biodiversity patterns and species abundances can be explained by assuming ecological equivalence among individuals regardless of species.
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D.
Fisher's fundamental theorem of natural selection
Fisher's fundamental theorem of natural selection is a key principle in evolutionary biology stating that the rate of increase in fitness of a population is proportional to its genetic variance in fitness.
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E.
Evolution in Mendelian Populations
"Evolution in Mendelian Populations" is a foundational 1931 paper by Sewall Wright that introduced key concepts of population genetics, including genetic drift, inbreeding, and the shifting balance theory of evolution.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: nearly neutral theory of molecular evolution Target entity description: The nearly neutral theory of molecular evolution is an extension of neutral theory that posits most evolutionary changes at the molecular level are due to mutations with very slight deleterious or advantageous effects whose fate is strongly influenced by genetic drift and population size.
-
A.
Motoo Kimura's neutral theory of molecular evolution
Motoo Kimura's neutral theory of molecular evolution is a foundational concept in evolutionary biology proposing that most genetic variation and molecular changes are selectively neutral and shaped primarily by random genetic drift rather than natural selection.
-
B.
neutral theory of population genetics
The neutral theory of population genetics is an evolutionary framework proposing that most genetic variation and molecular changes in populations are governed by random genetic drift of selectively neutral mutations rather than by natural selection.
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C.
Unified Neutral Theory of Biodiversity and Biogeography
Unified Neutral Theory of Biodiversity and Biogeography is an influential ecological theory proposing that biodiversity patterns and species abundances can be explained by assuming ecological equivalence among individuals regardless of species.
-
D.
Fisher's fundamental theorem of natural selection
Fisher's fundamental theorem of natural selection is a key principle in evolutionary biology stating that the rate of increase in fitness of a population is proportional to its genetic variance in fitness.
-
E.
Evolution in Mendelian Populations
"Evolution in Mendelian Populations" is a foundational 1931 paper by Sewall Wright that introduced key concepts of population genetics, including genetic drift, inbreeding, and the shifting balance theory of evolution.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
evolutionary theory
ⓘ
molecular evolution theory ⓘ population genetics theory ⓘ |
| accountsFor |
high levels of molecular polymorphism
ⓘ
lineage-specific differences in dN/dS ratios ⓘ |
| addresses | distribution of fitness effects of new mutations ⓘ |
| assumes |
boundary between neutral and selected mutations depends on population size
ⓘ
many mutations have very small selection coefficients ⓘ |
| basedOn | neutral theory of molecular evolution ⓘ |
| category |
theories of genetic drift
ⓘ
theories of molecular evolution ⓘ theories of natural selection ⓘ |
| contrastsWith | strict neutral theory of molecular evolution ⓘ |
| dependsOn | effective population size ⓘ |
| developedIn | 1970s ⓘ |
| emphasizes |
importance of nearly neutral mutations
ⓘ
interaction between selection and genetic drift ⓘ role of effective population size ⓘ |
| explains |
molecular clock patterns
ⓘ
variation in substitution rates among lineages ⓘ |
| extends | neutral theory of molecular evolution ⓘ |
| field |
evolutionary biology
ⓘ
molecular evolution ⓘ population genetics ⓘ |
| focusesOn | molecular level evolutionary changes ⓘ |
| hasImplication |
evolution of genome size
ⓘ
evolutionary rates in endosymbionts and island species ⓘ genome-wide patterns of constraint ⓘ |
| influencedBy | Motoo Kimura ⓘ |
| involvesConcept |
effective population size
ⓘ
fixation probability ⓘ genetic drift ⓘ natural selection ⓘ selection coefficient ⓘ slightly advantageous mutations ⓘ slightly deleterious mutations ⓘ |
| predicts |
greater fixation of slightly deleterious mutations in small populations
ⓘ
more efficient purifying selection in large populations ⓘ rate of molecular evolution can depend on population size ⓘ |
| proposedBy | Tomoko Ohta ⓘ |
| reconciles | molecular data with weak selection ⓘ |
| relatedTo | Kimura's neutral theory of molecular evolution ⓘ |
| statesThat |
most molecular mutations are slightly deleterious or slightly advantageous
ⓘ
the fate of slightly advantageous mutations is strongly influenced by genetic drift ⓘ the fate of slightly deleterious mutations is strongly influenced by genetic drift ⓘ |
| usedIn |
interpretation of divergence data
ⓘ
interpretation of polymorphism data ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: nearly neutral theory of molecular evolution Description of subject: The nearly neutral theory of molecular evolution is an extension of neutral theory that posits most evolutionary changes at the molecular level are due to mutations with very slight deleterious or advantageous effects whose fate is strongly influenced by genetic drift and population size.
Referenced by (6)
Full triples — surface form annotated when it differs from this entity's canonical label.
Motoo Kimura's neutral theory of molecular evolution
→
relatedConcept
→
nearly neutral theory of molecular evolution
ⓘ
linked to: nearly neutral theory of molecular evolution