Vivitrol
E597292
Vivitrol is an extended-release injectable formulation of naltrexone used to treat alcohol and opioid dependence by blocking the effects of these substances.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Vivitrol canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T6495526 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Vivitrol Context triple: [Alkermes, product, Vivitrol]
-
A.
Suboxone
Suboxone is a prescription medication combining buprenorphine and naloxone, primarily used to treat opioid dependence by reducing withdrawal symptoms and cravings.
-
B.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
-
C.
Truvada
Truvada is a prescription antiretroviral medication widely used both to treat HIV infection and as pre-exposure prophylaxis (PrEP) to help prevent HIV in high-risk individuals.
-
D.
Sovaldi
Sovaldi is a breakthrough antiviral medication used to treat chronic hepatitis C by directly inhibiting the virus’s replication.
-
E.
Biktarvy
Biktarvy is a prescription combination antiretroviral medication used to treat HIV-1 infection in adults and certain children.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Vivitrol Target entity description: Vivitrol is an extended-release injectable formulation of naltrexone used to treat alcohol and opioid dependence by blocking the effects of these substances.
-
A.
Suboxone
Suboxone is a prescription medication combining buprenorphine and naloxone, primarily used to treat opioid dependence by reducing withdrawal symptoms and cravings.
-
B.
Anpezan
Anpezan is a regional dialect of the Ladin language spoken in parts of the Dolomite area of northern Italy.
-
C.
Truvada
Truvada is a prescription antiretroviral medication widely used both to treat HIV infection and as pre-exposure prophylaxis (PrEP) to help prevent HIV in high-risk individuals.
-
D.
Sovaldi
Sovaldi is a breakthrough antiviral medication used to treat chronic hepatitis C by directly inhibiting the virus’s replication.
-
E.
Biktarvy
Biktarvy is a prescription combination antiretroviral medication used to treat HIV-1 infection in adults and certain children.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
brand name drug
ⓘ
extended-release injectable formulation ⓘ medication ⓘ |
| activeIngredient | naltrexone ⓘ |
| administrationBy | healthcare professional ⓘ |
| ATCCode | N07BB04 ⓘ |
| blackBoxWarning |
risk of hepatotoxicity with naltrexone
ⓘ
vulnerability to opioid overdose after treatment ⓘ |
| commonAdverseEffect |
dizziness
ⓘ
elevated liver enzymes ⓘ fatigue ⓘ headache ⓘ injection site pain ⓘ nausea ⓘ |
| contraindication |
acute hepatitis
ⓘ
acute opioid withdrawal ⓘ current opioid use ⓘ failure to pass naloxone challenge test ⓘ liver failure ⓘ positive opioid urine screen ⓘ |
| dosageForm | suspension for injection ⓘ |
| dosingInterval | once monthly ⓘ |
| effect |
blocks effects of exogenous opioids
ⓘ
reduces rewarding effects of alcohol ⓘ |
| eliminationHalfLife | approximately 5–10 days (extended-release) ⓘ |
| FDAApprovalYear | 2006 ⓘ |
| FDAApprovedFor |
prevention of relapse to opioid dependence after opioid detoxification
ⓘ
treatment of alcohol dependence ⓘ |
| formulationType | extended-release ⓘ |
| indication |
alcohol dependence
ⓘ
opioid dependence ⓘ prevention of relapse to opioid dependence ⓘ |
| legalStatus | prescription only ⓘ |
| manufacturer |
Alkermes plc
ⓘ
linked to:
Alkermes
|
| mechanismOfAction |
blocks mu-opioid receptors
ⓘ
opioid receptor antagonist ⓘ |
| pregnancyCategoryUS | Category C ⓘ |
| requires | opioid-free period of at least 7–10 days before initiation ⓘ |
| routeDetail | deep intramuscular injection in the gluteal muscle ⓘ |
| routeOfAdministration | intramuscular injection ⓘ |
| seriousAdverseEffect |
depression
ⓘ
hepatitis ⓘ injection site necrosis ⓘ suicidal ideation ⓘ |
| strength | 380 mg naltrexone base ⓘ |
| usedWith |
counseling
ⓘ
psychosocial support ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Vivitrol Description of subject: Vivitrol is an extended-release injectable formulation of naltrexone used to treat alcohol and opioid dependence by blocking the effects of these substances.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.