Mectizan

E579606

brand name pharmaceutical drug

Mectizan is the brand name for ivermectin, a medication widely used to prevent and treat river blindness (onchocerciasis) and certain other parasitic infections.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (3)

Label	Occurrences
Mectizan canonical	4
ivermectin	1
ivermectin (with collaborators)	1

How this entity was disambiguated

This entity first appeared as the object of triple T6251115 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: Mectizan
Context triple: [Decision to provide ivermectin (Mectizan) free of charge for river blindness, hasBrandName, Mectizan]

A. pyrantel pamoate
Pyrantel pamoate is an anthelmintic medication commonly used to treat intestinal worm infections such as pinworm, roundworm, and hookworm in humans.
B. albendazole
Albendazole is a broad-spectrum anthelmintic medication commonly used to treat a variety of parasitic worm infections in humans.
C. Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
D. Opekta
Opekta was a German-Dutch company that produced and sold pectin-based gelling agents for making jam, notably managed in its Amsterdam branch by Anne Frank’s father, Otto Frank.
E. Doxato
Doxato is a town in northern Greece located within the Drama regional unit, known for its agricultural surroundings and historical significance.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: Mectizan
Target entity description: Mectizan is the brand name for ivermectin, a medication widely used to prevent and treat river blindness (onchocerciasis) and certain other parasitic infections.

A. pyrantel pamoate
Pyrantel pamoate is an anthelmintic medication commonly used to treat intestinal worm infections such as pinworm, roundworm, and hookworm in humans.
B. albendazole
Albendazole is a broad-spectrum anthelmintic medication commonly used to treat a variety of parasitic worm infections in humans.
C. Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
D. Opekta
Opekta was a German-Dutch company that produced and sold pectin-based gelling agents for making jam, notably managed in its Amsterdam branch by Anne Frank’s father, Otto Frank.
E. Doxato
Doxato is a town in northern Greece located within the Drama regional unit, known for its agricultural surroundings and historical significance.
F. None of above. chosen

Statements (48)

Predicate	Object
instanceOf	brand name ⓘ pharmaceutical drug ⓘ
actsOn	parasites ⓘ
adverseEffectRelatedTo	Mazzotti reaction in onchocerciasis ⓘ
ATCCode	P02CF01 (ivermectin) ⓘ
commonAdverseEffect	fever ⓘ headache ⓘ itching ⓘ rash ⓘ
contraindication	known hypersensitivity to ivermectin ⓘ
developedBy	Merck & Co. ⓘ
distributedBy	Mectizan Donation Program ⓘ linked to: Merck Mectizan Donation Program
donatedFor	lymphatic filariasis elimination programs ⓘ onchocerciasis control programs ⓘ
drugClass	anthelmintic ⓘ antiparasitic ⓘ
effect	causes paralysis and death of susceptible parasites ⓘ
hasActiveIngredient	ivermectin ⓘ
hasDosageForm	oral tablet ⓘ oral tablet for mass drug administration ⓘ
hasFormulationStrength	3 mg tablet ⓘ 6 mg tablet ⓘ
indication	control of onchocerciasis transmission ⓘ prevention of onchocerciasis-related blindness ⓘ
legalStatus	prescription drug in many countries ⓘ
manufacturer	Merck & Co. ⓘ
mechanismOfAction	binds to glutamate-gated chloride channels in invertebrate nerve and muscle cells ⓘ
pregnancyCategory	use with caution; risk–benefit assessment required ⓘ
programAssociatedWith	Mectizan Donation Program ⓘ linked to: Merck Mectizan Donation Program
publicHealthRole	key medicine in global onchocerciasis control ⓘ key medicine in lymphatic filariasis elimination ⓘ
regimenType	mass drug administration ⓘ
routeOfAdministration	oral ⓘ
storageCondition	store at room temperature ⓘ
targetOrganism	Onchocerca volvulus microfilariae ⓘ
targetPopulation	people living in lymphatic filariasis-endemic areas ⓘ people living in onchocerciasis-endemic areas ⓘ
tradeNameOf	ivermectin ⓘ
typicalDosingRegimen	single oral dose given annually or semiannually in mass drug administration ⓘ
usedFor	lymphatic filariasis ⓘ onchocerciasis ⓘ other parasitic infections ⓘ river blindness ⓘ scabies ⓘ strongyloidiasis ⓘ
worldRegionOfUse	Africa ⓘ Latin America ⓘ Yemen ⓘ

How these facts were elicited

Referenced by (6)

Full triples — surface form annotated when it differs from this entity's canonical label.

Decision to provide ivermectin (Mectizan) free of charge for river blindness → hasBrandName → Mectizan ⓘ

Merck Mectizan Donation Program → usesDrugBrand → Mectizan ⓘ

Onchocerciasis Control Programme in West Africa → drugBrandName → Mectizan ⓘ

African Programme for Onchocerciasis Control → drugBrandName → Mectizan ⓘ

William C. Campbell → notableWork → ivermectin ⓘ

linked to: Mectizan

Satoshi Ōmura → developed → ivermectin (with collaborators) ⓘ