Rilutek
E561109
Rilutek is a brand-name medication containing riluzole, used to slow the progression of amyotrophic lateral sclerosis (ALS).
All labels observed (1)
| Label | Occurrences |
|---|---|
| Rilutek canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6005040 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Rilutek Context triple: [Riluzole, hasBrandName, Rilutek]
-
A.
Olite
Olite is a historic town in northern Spain renowned for its well-preserved medieval architecture and the royal palace of the kings of Navarre.
-
B.
Eltigen
Eltigen is a coastal village on the Kerch Peninsula in Crimea, historically notable as a key site of Soviet amphibious landings during World War II.
-
C.
Reitia
Reitia is an ancient goddess venerated by the Veneti people of northeastern Italy, often linked to writing, healing, and protection.
-
D.
Fremulon
Fremulon is a television production company founded by Michael Schur, best known for producing acclaimed comedy series such as Brooklyn Nine-Nine.
-
E.
Opekta
Opekta was a German-Dutch company that produced and sold pectin-based gelling agents for making jam, notably managed in its Amsterdam branch by Anne Frank’s father, Otto Frank.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Rilutek Target entity description: Rilutek is a brand-name medication containing riluzole, used to slow the progression of amyotrophic lateral sclerosis (ALS).
-
A.
Olite
Olite is a historic town in northern Spain renowned for its well-preserved medieval architecture and the royal palace of the kings of Navarre.
-
B.
Eltigen
Eltigen is a coastal village on the Kerch Peninsula in Crimea, historically notable as a key site of Soviet amphibious landings during World War II.
-
C.
Reitia
Reitia is an ancient goddess venerated by the Veneti people of northeastern Italy, often linked to writing, healing, and protection.
-
D.
Fremulon
Fremulon is a television production company founded by Michael Schur, best known for producing acclaimed comedy series such as Brooklyn Nine-Nine.
-
E.
Opekta
Opekta was a German-Dutch company that produced and sold pectin-based gelling agents for making jam, notably managed in its Amsterdam branch by Anne Frank’s father, Otto Frank.
- F. None of above. chosen
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
brand-name medication
ⓘ
pharmaceutical drug ⓘ riluzole-containing product ⓘ |
| actsOn | glutamatergic neurotransmission ⓘ |
| administrationSchedule | twice daily dosing is typical ⓘ |
| advice |
avoid high-fat meals close to dosing
ⓘ
take on an empty stomach ⓘ |
| approvedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
| approvedFor | treatment of ALS ⓘ |
| belongsTo | ALS disease-modifying therapies ⓘ |
| commonAdverseEffect |
dizziness
ⓘ
elevated liver enzymes ⓘ nausea ⓘ weakness ⓘ |
| contains | riluzole 50 mg per tablet (typical strength) ⓘ |
| contraindication |
history of severe hypersensitivity to riluzole
ⓘ
severe hepatic impairment ⓘ |
| developedFor | modifying disease course in ALS ⓘ |
| doesNot | cure ALS ⓘ |
| dosageForm | oral tablet ⓘ |
| drugInteraction |
CYP1A2 inducers may decrease riluzole exposure
ⓘ
CYP1A2 inhibitors may increase riluzole exposure ⓘ |
| effect |
delays need for tracheostomy in ALS patients
ⓘ
modestly prolongs survival in ALS ⓘ |
| eliminationRoute | renal excretion of metabolites ⓘ |
| hasActiveIngredient | riluzole ⓘ |
| hasATCCode | N07XX02 ⓘ |
| indicatedFor |
ALS
ⓘ
amyotrophic lateral sclerosis ⓘ |
| mechanismOfAction |
inactivates voltage-dependent sodium channels in CNS
ⓘ
inhibits glutamate release ⓘ interferes with intracellular events following excitatory amino acid receptor binding ⓘ |
| metabolism | extensively metabolized in the liver ⓘ |
| metabolizingEnzyme | CYP1A2 ⓘ |
| notIndicatedFor | pediatric patients ⓘ |
| pharmacologicalClass | glutamate release inhibitor ⓘ |
| pregnancyCategory | use only if potential benefit justifies potential risk ⓘ |
| regulatoryStatus | prescription-only medicine ⓘ |
| requiresMonitoring | liver function tests ⓘ |
| routeOfAdministration | oral ⓘ |
| seriousAdverseEffect | hepatotoxicity ⓘ |
| storageCondition | store at controlled room temperature ⓘ |
| targetPopulation | adults with ALS ⓘ |
| therapeuticUse | slowing progression of ALS ⓘ |
| warning |
discontinue if significant liver enzyme elevation occurs
ⓘ
use with caution in patients with liver disease ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Rilutek Description of subject: Rilutek is a brand-name medication containing riluzole, used to slow the progression of amyotrophic lateral sclerosis (ALS).
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
riluzole