glycinamide ribonucleotide formyltransferase
E561031
Glycinamide ribonucleotide formyltransferase is a key enzyme in the de novo purine biosynthesis pathway that catalyzes a formylation step essential for nucleotide production and is targeted by certain anticancer drugs.
All labels observed (1)
| Label | Occurrences |
|---|---|
| glycinamide ribonucleotide formyltransferase canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6003489 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: glycinamide ribonucleotide formyltransferase Context triple: [Alimta, targetsEnzyme, glycinamide ribonucleotide formyltransferase]
-
A.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
-
B.
DNA ligase
DNA ligase is an essential enzyme that joins breaks in the sugar-phosphate backbone of DNA, enabling processes such as DNA replication and genetic recombination.
-
C.
Edman
Edman is a masculine given name most notably borne by Edman Spangler, a carpenter implicated in the conspiracy surrounding U.S. President Abraham Lincoln’s assassination.
-
D.
GFATM
GFATM is a global financing institution that mobilizes and invests resources to combat HIV/AIDS, tuberculosis, and malaria in low- and middle-income countries.
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E.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: glycinamide ribonucleotide formyltransferase Target entity description: Glycinamide ribonucleotide formyltransferase is a key enzyme in the de novo purine biosynthesis pathway that catalyzes a formylation step essential for nucleotide production and is targeted by certain anticancer drugs.
-
A.
Flavin
Flavin is a surname most notably associated with American minimalist artist Dan Flavin, renowned for his fluorescent light installations.
-
B.
DNA ligase
DNA ligase is an essential enzyme that joins breaks in the sugar-phosphate backbone of DNA, enabling processes such as DNA replication and genetic recombination.
-
C.
Edman
Edman is a masculine given name most notably borne by Edman Spangler, a carpenter implicated in the conspiracy surrounding U.S. President Abraham Lincoln’s assassination.
-
D.
GFATM
GFATM is a global financing institution that mobilizes and invests resources to combat HIV/AIDS, tuberculosis, and malaria in low- and middle-income countries.
-
E.
Gi protein
Gi protein is a subtype of heterotrimeric G protein that inhibits adenylyl cyclase activity and modulates various intracellular signaling pathways when activated by G protein–coupled receptors.
- F. None of above. chosen
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
enzyme
ⓘ
formyltransferase ⓘ transferase ⓘ |
| associatedWith |
DNA synthesis
ⓘ
RNA synthesis ⓘ cell proliferation ⓘ |
| belongsToPathway | one-carbon metabolism via folate ⓘ |
| biologicalProcess |
nucleotide biosynthetic process
ⓘ
purine-containing compound biosynthetic process ⓘ |
| catalyzesReaction | formylation of glycinamide ribonucleotide to formylglycinamide ribonucleotide ⓘ |
| cellularLocation | cytosol ⓘ |
| dependsOn | availability of folate derivatives ⓘ |
| ECNumber | 2.1.2.2 ⓘ |
| essentialFor |
ATP biosynthesis
ⓘ
GTP biosynthesis ⓘ purine nucleotide biosynthesis ⓘ |
| foundIn |
animals
ⓘ
bacteria ⓘ humans ⓘ plants ⓘ yeast ⓘ |
| geneSymbolInHuman | GART ⓘ |
| inhibitedBy | antifolate inhibitors of de novo purine synthesis ⓘ |
| isDomainOf | phosphoribosylglycinamide formyltransferase / phosphoribosylglycinamide synthetase / phosphoribosylaminoimidazole synthetase ⓘ |
| isPartOf | trifunctional GART protein in humans ⓘ |
| isRateLimitingIn | certain steps of de novo purine biosynthesis ⓘ |
| isStepOf | multistep pathway from phosphoribosyl pyrophosphate to inosine monophosphate ⓘ |
| isTargetIn | antimetabolite chemotherapy strategies ⓘ |
| molecularFunction |
glycinamide ribonucleotide formyltransferase activity
ⓘ
one-carbon group transfer ⓘ |
| orthologIn |
Arabidopsis thaliana
ⓘ
Escherichia coli ⓘ Mus musculus ⓘ
linked to:
house mouse (Mus musculus)
Saccharomyces cerevisiae ⓘ |
| participatesIn |
IMP biosynthetic process
ⓘ
de novo purine biosynthesis ⓘ |
| produces | formylglycinamide ribonucleotide ⓘ |
| product |
formylglycinamide ribonucleotide
ⓘ
tetrahydrofolate ⓘ |
| requires | folate metabolism ⓘ |
| substrate |
10-formyltetrahydrofolate
ⓘ
glycinamide ribonucleotide ⓘ |
| targetOf |
antifolate drugs
ⓘ
certain anticancer drugs ⓘ |
| usesCofactor | 10-formyltetrahydrofolate ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: glycinamide ribonucleotide formyltransferase Description of subject: Glycinamide ribonucleotide formyltransferase is a key enzyme in the de novo purine biosynthesis pathway that catalyzes a formylation step essential for nucleotide production and is targeted by certain anticancer drugs.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.