voriconazole
E556657
Voriconazole is a broad-spectrum triazole antifungal medication commonly used to treat serious invasive fungal infections, particularly those caused by Aspergillus species.
All labels observed (1)
| Label | Occurrences |
|---|---|
| voriconazole canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T5931496 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: voriconazole Context triple: [Aspergillus fumigatus, treatedWith, voriconazole]
-
A.
Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
-
B.
Efate
Efate is a central island of Vanuatu that hosts the nation’s capital, Port Vila, and serves as its main political and economic hub.
-
C.
velpatasvir
Velpatasvir is a direct-acting antiviral medication used in combination with sofosbuvir to treat chronic hepatitis C virus infection across multiple genotypes.
-
D.
Biktarvy
Biktarvy is a prescription combination antiretroviral medication used to treat HIV-1 infection in adults and certain children.
-
E.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: voriconazole Target entity description: Voriconazole is a broad-spectrum triazole antifungal medication commonly used to treat serious invasive fungal infections, particularly those caused by Aspergillus species.
-
A.
Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
-
B.
Efate
Efate is a central island of Vanuatu that hosts the nation’s capital, Port Vila, and serves as its main political and economic hub.
-
C.
velpatasvir
Velpatasvir is a direct-acting antiviral medication used in combination with sofosbuvir to treat chronic hepatitis C virus infection across multiple genotypes.
-
D.
Biktarvy
Biktarvy is a prescription combination antiretroviral medication used to treat HIV-1 infection in adults and certain children.
-
E.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
azole antifungal
ⓘ
broad-spectrum antifungal agent ⓘ triazole antifungal drug ⓘ |
| affectsPathway | ergosterol biosynthesis ⓘ |
| hasAdministrationForm |
intravenous solution
ⓘ
oral suspension ⓘ tablet ⓘ |
| hasATCCode | J02AC03 ⓘ |
| hasBrandName | Vfend ⓘ |
| hasChemicalClass | triazole ⓘ |
| hasCommonAdverseEffect |
elevated liver enzymes
ⓘ
photosensitivity ⓘ rash ⓘ visual disturbances ⓘ |
| hasContraindication | coadministration with certain CYP3A4 substrates that prolong QT interval ⓘ |
| hasDrugInteraction |
CYP3A4 inducers
ⓘ
CYP3A4 inhibitors ⓘ carbamazepine ⓘ phenytoin ⓘ rifampin ⓘ |
| hasEffect | disruption of fungal cell membrane formation ⓘ |
| hasMechanismOfAction | inhibition of fungal cytochrome P450–dependent 14α-sterol demethylase ⓘ |
| hasPharmacokineticsProperty |
high oral bioavailability
ⓘ
nonlinear pharmacokinetics ⓘ |
| hasPregnancyCategory | D (US, historical classification) ⓘ |
| hasRouteConsideration | loading dose recommended for intravenous use ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| hasSeriousAdverseEffect |
QT interval prolongation
ⓘ
hepatotoxicity ⓘ torsades de pointes ⓘ |
| hasSpectrumOfActivity |
molds
ⓘ
yeasts ⓘ |
| hasTargetOrganism |
Aspergillus species
ⓘ
linked to:
Aspergillus
Candida species ⓘ |
| inhibits | lanosterol 14α-demethylase ⓘ |
| isDerivedFrom | fluconazole analogue ⓘ |
| isIndicatedFor | immunocompromised patients with invasive fungal infections ⓘ |
| isMetabolizedBy |
CYP2C19
ⓘ
CYP2C9 ⓘ CYP3A4 ⓘ |
| treats |
Fusarium infections
ⓘ
Scedosporium infections ⓘ candidemia ⓘ esophageal candidiasis ⓘ invasive aspergillosis ⓘ invasive fungal infections ⓘ |
| wasApprovedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: voriconazole Description of subject: Voriconazole is a broad-spectrum triazole antifungal medication commonly used to treat serious invasive fungal infections, particularly those caused by Aspergillus species.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.