Fasenra
E505485
Fasenra is a monoclonal antibody medication used to treat severe eosinophilic asthma by targeting and reducing eosinophil levels.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Fasenra canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T5248767 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Fasenra Context triple: [AstraZeneca, notableProduct, Fasenra]
-
A.
Renaelva
Renaelva is a river in eastern Norway that flows through Hedmark county before joining the larger Glomma river.
-
B.
Yasa'ur
Yasa'ur was a Mongol prince and military leader who played a significant role in the politics and conflicts of the Chagatai Khanate during the early 14th century.
-
C.
Baradine
Baradine is a small rural town in New South Wales, Australia, known as a gateway to the Pilliga Forest and for its agricultural and forestry activities.
-
D.
Teurnia
Teurnia was an important ancient Roman city that served as a major administrative and cultural center in the province of Noricum, located in what is now southern Austria.
-
E.
Frosta
Frosta is a rural municipality and peninsula in Trøndelag county, Norway, known for its fertile farmland and historical significance as a medieval assembly site.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Fasenra Target entity description: Fasenra is a monoclonal antibody medication used to treat severe eosinophilic asthma by targeting and reducing eosinophil levels.
-
A.
Renaelva
Renaelva is a river in eastern Norway that flows through Hedmark county before joining the larger Glomma river.
-
B.
Yasa'ur
Yasa'ur was a Mongol prince and military leader who played a significant role in the politics and conflicts of the Chagatai Khanate during the early 14th century.
-
C.
Baradine
Baradine is a small rural town in New South Wales, Australia, known as a gateway to the Pilliga Forest and for its agricultural and forestry activities.
-
D.
Teurnia
Teurnia was an important ancient Roman city that served as a major administrative and cultural center in the province of Noricum, located in what is now southern Austria.
-
E.
Frosta
Frosta is a rural municipality and peninsula in Trøndelag county, Norway, known for its fertile farmland and historical significance as a medieval assembly site.
- F. None of above. chosen
Statements (45)
| Predicate | Object |
|---|---|
| instanceOf |
medication
ⓘ
monoclonal antibody ⓘ |
| administrationFrequencyMaintenance | every 8 weeks ⓘ |
| administrationSetting | healthcare professional supervision ⓘ |
| antibodyType | IgG1 kappa ⓘ |
| approvalYear | 2017 ⓘ |
| approvedBy |
European Medicines Agency
ⓘ
U.S. Food and Drug Administration ⓘ
linked to:
Food and Drug Administration
|
| bindingTargetCellType |
basophils
ⓘ
eosinophils ⓘ |
| commonAdverseEffect |
headache
ⓘ
injection site reactions ⓘ pharyngitis ⓘ |
| contraindication | known hypersensitivity to benralizumab ⓘ |
| developedBy |
AstraZeneca
ⓘ
MedImmune ⓘ |
| dosingRegimen |
initially every 4 weeks for the first 3 doses
ⓘ
then every 8 weeks ⓘ |
| hasATCCode | R03DX10 ⓘ |
| hasDosageForm |
autoinjector pen
ⓘ
prefilled syringe ⓘ solution for injection ⓘ |
| hasDrugClass | interleukin-5 receptor alpha antagonist ⓘ |
| hasGenericName | benralizumab ⓘ |
| improves |
asthma symptom control
ⓘ
lung function in severe eosinophilic asthma ⓘ |
| indicatedFor | add-on maintenance treatment of severe eosinophilic asthma ⓘ |
| induces | apoptosis of eosinophils via NK cell-mediated cytotoxicity ⓘ |
| isBrandNameOf | benralizumab ⓘ |
| isHumanized | true ⓘ |
| isNotIndicatedFor |
acute bronchospasm
ⓘ
status asthmaticus ⓘ |
| isPrescriptionOnly | true ⓘ |
| mechanismOfAction |
induces antibody-dependent cell-mediated cytotoxicity of eosinophils
ⓘ
reduces eosinophil levels ⓘ |
| origin | recombinant DNA technology ⓘ |
| pregnancyCategory | insufficient human data ⓘ |
| reduces |
asthma exacerbation rate
ⓘ
blood eosinophil counts ⓘ |
| routeOfAdministration | subcutaneous injection ⓘ |
| seriousAdverseEffect | hypersensitivity reactions ⓘ |
| targets | interleukin-5 receptor alpha ⓘ |
| therapeuticArea |
allergy and immunology
ⓘ
respiratory disease ⓘ |
| treats | severe eosinophilic asthma ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Fasenra Description of subject: Fasenra is a monoclonal antibody medication used to treat severe eosinophilic asthma by targeting and reducing eosinophil levels.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.