Enantioselective Chemical Synthesis
E466664
Enantioselective Chemical Synthesis is a foundational work in organic chemistry that systematically presents strategies and methods for constructing chiral molecules with high stereocontrol.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Enantioselective Chemical Synthesis canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4741213 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Enantioselective Chemical Synthesis Context triple: [E. J. Corey, hasWritten, Enantioselective Chemical Synthesis]
-
A.
The Logic of Chemical Synthesis
The Logic of Chemical Synthesis is a seminal book by chemist Elias J. Corey that systematically presents the principles and strategies of retrosynthetic analysis for designing complex organic molecule syntheses.
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B.
Eschenmoser sulfide contraction
Eschenmoser sulfide contraction is an organic rearrangement reaction that converts certain sulfur-containing intermediates into carbonyl compounds, widely used in complex molecule and natural product synthesis.
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C.
Trost asymmetric allylic alkylation
Trost asymmetric allylic alkylation is a palladium-catalyzed enantioselective carbon–carbon bond-forming reaction that enables the synthesis of chiral molecules from prochiral allylic substrates.
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D.
Sharpless asymmetric dihydroxylation
Sharpless asymmetric dihydroxylation is a landmark chemical reaction that uses chiral catalysts to add two hydroxyl groups across an alkene with high enantioselectivity, revolutionizing asymmetric synthesis in organic chemistry.
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E.
Buchwald–Hartwig amination
The Buchwald–Hartwig amination is a palladium-catalyzed cross-coupling reaction that forms carbon–nitrogen bonds by coupling aryl (or vinyl) halides with amines, widely used in the synthesis of pharmaceuticals and fine chemicals.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Enantioselective Chemical Synthesis Target entity description: Enantioselective Chemical Synthesis is a foundational work in organic chemistry that systematically presents strategies and methods for constructing chiral molecules with high stereocontrol.
-
A.
The Logic of Chemical Synthesis
The Logic of Chemical Synthesis is a seminal book by chemist Elias J. Corey that systematically presents the principles and strategies of retrosynthetic analysis for designing complex organic molecule syntheses.
-
B.
Eschenmoser sulfide contraction
Eschenmoser sulfide contraction is an organic rearrangement reaction that converts certain sulfur-containing intermediates into carbonyl compounds, widely used in complex molecule and natural product synthesis.
-
C.
Trost asymmetric allylic alkylation
Trost asymmetric allylic alkylation is a palladium-catalyzed enantioselective carbon–carbon bond-forming reaction that enables the synthesis of chiral molecules from prochiral allylic substrates.
-
D.
Sharpless asymmetric dihydroxylation
Sharpless asymmetric dihydroxylation is a landmark chemical reaction that uses chiral catalysts to add two hydroxyl groups across an alkene with high enantioselectivity, revolutionizing asymmetric synthesis in organic chemistry.
-
E.
Buchwald–Hartwig amination
The Buchwald–Hartwig amination is a palladium-catalyzed cross-coupling reaction that forms carbon–nitrogen bonds by coupling aryl (or vinyl) halides with amines, widely used in the synthesis of pharmaceuticals and fine chemicals.
- F. None of above. chosen
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
book
ⓘ
chemistry textbook ⓘ scientific monograph ⓘ |
| aimsTo |
enable high levels of stereocontrol
ⓘ
guide the design of chiral molecules ⓘ provide systematic strategies for enantioselective synthesis ⓘ |
| contributesTo |
development of stereoselective synthetic methodology
ⓘ
understanding of chiral molecule construction ⓘ |
| covers |
biocatalytic enantioselective reactions
ⓘ
chiral ligand design ⓘ metal-catalyzed asymmetric reactions ⓘ organocatalysis ⓘ principles of enantioselectivity ⓘ principles of stereoselectivity ⓘ transition-state models for stereocontrol ⓘ |
| describes |
enantioselective C–C bond-forming reactions
ⓘ
enantioselective addition reactions ⓘ enantioselective catalysis design principles ⓘ enantioselective oxidation reactions ⓘ enantioselective reduction reactions ⓘ enantioselective substitution reactions ⓘ methods for constructing chiral centers ⓘ methods for constructing stereogenic centers ⓘ strategies for asymmetric synthesis ⓘ |
| field |
asymmetric synthesis
ⓘ
organic chemistry ⓘ stereochemistry ⓘ |
| focusesOn |
asymmetric catalysis
ⓘ
chiral auxiliaries ⓘ chiral pool synthesis ⓘ construction of chiral molecules ⓘ enantioselective catalysts ⓘ enantioselective reactions ⓘ enantioselective reagents ⓘ enantioselective transformations ⓘ stereocontrol in organic synthesis ⓘ |
| hasKeyConcept |
chiral recognition
ⓘ
diastereoselective control ⓘ enantioselective amplification ⓘ enantioselective catalysis mechanisms ⓘ enantioselective induction ⓘ |
| usedBy |
medicinal chemists
ⓘ
process chemists ⓘ synthetic organic chemists ⓘ |
| usedIn |
graduate-level organic chemistry education
ⓘ
research in asymmetric synthesis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Enantioselective Chemical Synthesis Description of subject: Enantioselective Chemical Synthesis is a foundational work in organic chemistry that systematically presents strategies and methods for constructing chiral molecules with high stereocontrol.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.