major histocompatibility complex (MHC)

E461225

cell-surface molecule gene cluster immune system component protein complex

The major histocompatibility complex (MHC) is a set of cell-surface proteins essential for the immune system to recognize foreign molecules and present antigens to T cells, playing a central role in adaptive immunity and transplant compatibility.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (3)

Label	Occurrences
MHC	1
human leukocyte antigen system	1
major histocompatibility complex (MHC) canonical	1

How this entity was disambiguated

This entity first appeared as the object of triple T4667792 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: major histocompatibility complex (MHC)
Context triple: [Rolf Zinkernagel, hasResearchFocus, major histocompatibility complex (MHC)]

A. HLA
HLA is the three-letter IATA airport code for Lanseria International Airport, a major privately owned airport serving the Johannesburg region in South Africa.
B. B lymphocytes
B lymphocytes are a type of white blood cell central to the adaptive immune system, responsible for producing antibodies and mediating humoral immunity.
C. ABO blood group system
The ABO blood group system is the primary human blood classification method based on the presence or absence of specific antigens on red blood cells, crucial for safe blood transfusions and organ transplantation.
D. ISOTYPE
ISOTYPE is a pictorial language and visual communication system developed in the 1920s–30s to present complex social and economic data through standardized icons and charts.
E. LHM
LHM is the station code for Lillehammer railway station in Norway.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: major histocompatibility complex (MHC)
Target entity description: The major histocompatibility complex (MHC) is a set of cell-surface proteins essential for the immune system to recognize foreign molecules and present antigens to T cells, playing a central role in adaptive immunity and transplant compatibility.

A. HLA
HLA is the three-letter IATA airport code for Lanseria International Airport, a major privately owned airport serving the Johannesburg region in South Africa.
B. B lymphocytes
B lymphocytes are a type of white blood cell central to the adaptive immune system, responsible for producing antibodies and mediating humoral immunity.
C. ABO blood group system
The ABO blood group system is the primary human blood classification method based on the presence or absence of specific antigens on red blood cells, crucial for safe blood transfusions and organ transplantation.
D. ISOTYPE
ISOTYPE is a pictorial language and visual communication system developed in the 1920s–30s to present complex social and economic data through standardized icons and charts.
E. LHM
LHM is the station code for Lillehammer railway station in Norway.
F. None of above. chosen

Statements (49)

Predicate	Object
instanceOf	cell-surface molecule ⓘ gene cluster ⓘ immune system component ⓘ protein complex ⓘ
abbreviatedAs	HLA in humans ⓘ
alsoKnownAs	MHC ⓘ linked to: major histocompatibility complex (MHC)
associatedWith	HLA-B27 ⓘ HLA-DRB1 alleles ⓘ ankylosing spondylitis risk ⓘ celiac disease risk ⓘ type 1 diabetes risk ⓘ
binds	foreign peptides ⓘ peptide antigens ⓘ self peptides ⓘ
encodedBy	MHC genes ⓘ
evolvedUnder	balancing selection ⓘ
expressedOn	cell surface ⓘ
foundIn	humans ⓘ jawed vertebrates ⓘ mammals ⓘ
hasFunction	interact with CD4 and CD8 co-receptors ⓘ present endogenous antigens via class I ⓘ present exogenous antigens via class II ⓘ shape T cell repertoire during thymic selection ⓘ
hasPart	MHC class I ⓘ MHC class II ⓘ MHC class III ⓘ
hasProperty	co-dominantly expressed ⓘ highly polymorphic ⓘ polygenic ⓘ
hasRegion	class I region ⓘ class II region ⓘ class III region ⓘ
inHumansCalled	human leukocyte antigen system ⓘ linked to: major histocompatibility complex (MHC)
involvedIn	autoimmune disease susceptibility ⓘ graft rejection ⓘ mate selection in some species ⓘ pathogen resistance ⓘ tissue typing ⓘ
locatedOn	chromosome 6 in humans ⓘ
playsRoleIn	T cell activation ⓘ adaptive immunity ⓘ antigen presentation ⓘ immune surveillance ⓘ self–non-self discrimination ⓘ transplant compatibility ⓘ
recognizedBy	CD4+ T cells ⓘ CD8+ T cells ⓘ T cell receptors ⓘ