pyrantel pamoate
E400813
Pyrantel pamoate is an anthelmintic medication commonly used to treat intestinal worm infections such as pinworm, roundworm, and hookworm in humans.
All labels observed (1)
| Label | Occurrences |
|---|---|
| pyrantel pamoate canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T3927143 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: pyrantel pamoate Context triple: [Enterobius vermicularis, treatment, pyrantel pamoate]
-
A.
albendazole
Albendazole is a broad-spectrum anthelmintic medication commonly used to treat a variety of parasitic worm infections in humans.
-
B.
Wormit
Wormit is a small village in Fife, Scotland, situated on the south bank of the River Tay near the Tay Rail Bridge.
-
C.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
D.
Opekta
Opekta was a German-Dutch company that produced and sold pectin-based gelling agents for making jam, notably managed in its Amsterdam branch by Anne Frank’s father, Otto Frank.
-
E.
Ascaris lumbricoides
Ascaris lumbricoides is a large parasitic roundworm that infects the human intestine and is a common cause of ascariasis worldwide.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: pyrantel pamoate Target entity description: Pyrantel pamoate is an anthelmintic medication commonly used to treat intestinal worm infections such as pinworm, roundworm, and hookworm in humans.
-
A.
albendazole
Albendazole is a broad-spectrum anthelmintic medication commonly used to treat a variety of parasitic worm infections in humans.
-
B.
Wormit
Wormit is a small village in Fife, Scotland, situated on the south bank of the River Tay near the Tay Rail Bridge.
-
C.
Plaxtol
Plaxtol is a small rural village and civil parish in Kent, England, known for its historic buildings and surrounding countryside.
-
D.
Opekta
Opekta was a German-Dutch company that produced and sold pectin-based gelling agents for making jam, notably managed in its Amsterdam branch by Anne Frank’s father, Otto Frank.
-
E.
Ascaris lumbricoides
Ascaris lumbricoides is a large parasitic roundworm that infects the human intestine and is a common cause of ascariasis worldwide.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
anthelmintic drug
ⓘ
pyrimidine derivative ⓘ tetrahydropyrimidine anthelmintic ⓘ |
| availableAs |
chewable tablet
ⓘ
oral suspension ⓘ |
| contraindicatedIn | known hypersensitivity to pyrantel ⓘ |
| developedBy | Pfizer ⓘ |
| discoveredIn | 1960s ⓘ |
| effectOnParasite |
causes detachment of worms from intestinal wall
ⓘ
leads to expulsion of worms via peristalsis ⓘ |
| excretion | primarily excreted in feces ⓘ |
| hasActiveIngredient | pyrantel ⓘ |
| hasAdverseEffect |
abdominal cramps
ⓘ
diarrhea ⓘ dizziness ⓘ elevated liver enzymes ⓘ headache ⓘ nausea ⓘ vomiting ⓘ |
| hasATCCode | P02CC01 ⓘ |
| hasBioavailability | poorly absorbed from gastrointestinal tract ⓘ |
| hasCASNumber | 22204-24-6 ⓘ |
| hasCounterion | pamoate ⓘ |
| hasDrugInteraction | piperazine ⓘ |
| hasLegalStatus |
over-the-counter drug in some countries
ⓘ
prescription drug in some countries ⓘ |
| hasMolecularFormula |
C11H14N2S·C23H16O6
ⓘ
C34H30N2O6S ⓘ |
| hasPregnancyCategory | generally considered low risk in pregnancy when clearly needed ⓘ |
| hasRouteOfAdministration | oral ⓘ |
| interactionEffect | piperazine may antagonize the anthelmintic effect of pyrantel ⓘ |
| isOn | World Health Organization Model List of Essential Medicines ⓘ |
| mechanismOfAction |
acts as a nicotinic acetylcholine receptor agonist in nematodes
ⓘ
causes spastic paralysis of susceptible worms ⓘ depolarizing neuromuscular blocking agent in susceptible helminths ⓘ |
| primarySiteOfAction | intestinal lumen ⓘ |
| usedFor |
treatment of Ancylostoma duodenale infection
ⓘ
treatment of Ascaris lumbricoides infection ⓘ treatment of Enterobius vermicularis infection ⓘ treatment of Necator americanus infection ⓘ treatment of hookworm infection ⓘ treatment of intestinal helminth infections ⓘ treatment of intestinal nematode infections in animals ⓘ treatment of pinworm infection ⓘ treatment of roundworm infection ⓘ |
| usedIn |
human medicine
ⓘ
veterinary medicine ⓘ |
| useWithCautionIn | patients with liver impairment ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: pyrantel pamoate Description of subject: Pyrantel pamoate is an anthelmintic medication commonly used to treat intestinal worm infections such as pinworm, roundworm, and hookworm in humans.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.