Hodgkin–Huxley model

E381979

The Hodgkin–Huxley model is a mathematical description of how action potentials in neurons are initiated and propagated through voltage-gated ion channels in the cell membrane.

All labels observed (2)

How this entity was disambiguated

Statements (48)

Predicate Object
instanceOf biophysical model
computational neuroscience model
mathematical model
appliesTo neuronal cell membrane
approach conductance-based description of membrane currents
assumes isopotential membrane patch
voltage-dependent rate constants
awarded Nobel Prize in Physiology or Medicine 1963 (to its developers)
basedOn voltage clamp experiments
characterizedBy refractory period dynamics
threshold behavior of action potentials
voltage-dependent ion channel kinetics
describes generation of action potentials
membrane potential dynamics
propagation of action potentials
voltage-gated ion channel dynamics
developedBy Alan Lloyd Hodgkin
linked to: Alan Hodgkin

Andrew Fielding Huxley
linked to: Andrew Huxley
developedFor giant axon of the squid
field biophysics
computational biology
neuroscience
hasGatingVariable h
m
n
hasParameter leak conductance
leak reversal potential
maximum potassium conductance
maximum sodium conductance
membrane capacitance per unit area
potassium reversal potential
sodium reversal potential
includes gating variables
leak current
membrane capacitance
potassium current
sodium current
influenced FitzHugh–Nagumo model
Morris–Lecar model
conductance-based neuron models
integrate-and-fire neuron models
mathematicalForm set of coupled ordinary differential equations
publicationYear 1952
publishedIn The Journal of Physiology
usedIn cardiac electrophysiology modeling
computational simulations of neurons
neural excitability studies
uses nonlinear differential equations

How these facts were elicited

Referenced by (6)

Full triples — surface form annotated when it differs from this entity's canonical label.

Alan Hodgkin knownFor Hodgkin–Huxley model
Alan Hodgkin developedModel Hodgkin–Huxley model of the action potential
linked to: Hodgkin–Huxley model
all-or-none principle in nerve excitation isFundamentalTo Hodgkin–Huxley model of the action potential
linked to: Hodgkin–Huxley model
Julius Bernstein influenced Hodgkin–Huxley model of the action potential
linked to: Hodgkin–Huxley model
Andrew Huxley notableWork Hodgkin–Huxley model
Alan Lloyd Hodgkin knownFor Hodgkin–Huxley model
subject linked to: Hodgkin family