Hodgkin–Huxley model

E381979

The Hodgkin–Huxley model is a mathematical description of how action potentials in neurons are initiated and propagated through voltage-gated ion channels in the cell membrane.

All labels observed (3)

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Statements (48)

Predicate Object
instanceOf biophysical model ⓘ
computational neuroscience model ⓘ
mathematical model ⓘ
appliesTo neuronal cell membrane ⓘ
approach conductance-based description of membrane currents ⓘ
assumes isopotential membrane patch ⓘ
voltage-dependent rate constants ⓘ
awarded Nobel Prize in Physiology or Medicine 1963 (to its developers) ⓘ
basedOn voltage clamp experiments ⓘ
characterizedBy refractory period dynamics ⓘ
threshold behavior of action potentials ⓘ
voltage-dependent ion channel kinetics ⓘ
describes generation of action potentials ⓘ
membrane potential dynamics ⓘ
propagation of action potentials ⓘ
voltage-gated ion channel dynamics ⓘ
developedBy Alan Lloyd Hodgkin ⓘ
linked to: Alan Hodgkin

Andrew Fielding Huxley ⓘ
linked to: Andrew Huxley
developedFor giant axon of the squid ⓘ
field biophysics ⓘ
computational biology ⓘ
neuroscience ⓘ
hasGatingVariable h ⓘ
m ⓘ
n ⓘ
hasParameter leak conductance ⓘ
leak reversal potential ⓘ
maximum potassium conductance ⓘ
maximum sodium conductance ⓘ
membrane capacitance per unit area ⓘ
potassium reversal potential ⓘ
sodium reversal potential ⓘ
includes gating variables ⓘ
leak current ⓘ
membrane capacitance ⓘ
potassium current ⓘ
sodium current ⓘ
influenced FitzHugh–Nagumo model ⓘ
Morris–Lecar model ⓘ
conductance-based neuron models ⓘ
integrate-and-fire neuron models ⓘ
mathematicalForm set of coupled ordinary differential equations ⓘ
publicationYear 1952 ⓘ
publishedIn The Journal of Physiology ⓘ
usedIn cardiac electrophysiology modeling ⓘ
computational simulations of neurons ⓘ
neural excitability studies ⓘ
uses nonlinear differential equations ⓘ

How these facts were elicited

Referenced by (8)

Full triples — surface form annotated when it differs from this entity's canonical label.

Alan Hodgkin → knownFor → Hodgkin–Huxley model ⓘ
Alan Hodgkin → developedModel → Hodgkin–Huxley model of the action potential ⓘ
linked to: Hodgkin–Huxley model
all-or-none principle in nerve excitation → isFundamentalTo → Hodgkin–Huxley model of the action potential ⓘ
linked to: Hodgkin–Huxley model
Julius Bernstein → influenced → Hodgkin–Huxley model of the action potential ⓘ
linked to: Hodgkin–Huxley model
Andrew Huxley → notableWork → Hodgkin–Huxley model ⓘ
Alan Lloyd Hodgkin → knownFor → Hodgkin–Huxley model ⓘ
subject linked to: Hodgkin family
Goldman–Hodgkin–Katz equation → usedIn → Hodgkin–Huxley model ⓘ
Biophysics of Computation: Information Processing in Single Neurons → topic → Hodgkin–Huxley models ⓘ
linked to: Hodgkin–Huxley model