Spinraza
E24879
Spinraza is a prescription medication used to treat spinal muscular atrophy (SMA) by modifying SMN2 gene expression to increase production of survival motor neuron (SMN) protein.
All labels observed (3)
| Label | Occurrences |
|---|---|
| nusinersen | 7 |
| Spinraza canonical | 4 |
| SMN2 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T195375 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Spinraza Context triple: [Biogen, hasProduct, Spinraza]
-
A.
Pregny-Chambésy
Pregny-Chambésy is a small, affluent municipality on the shores of Lake Geneva in the canton of Geneva, Switzerland, known for hosting several international organizations and diplomatic missions.
-
B.
Philortyx
Philortyx is a genus of New World quails known for their ground-dwelling habits and occurrence in scrub and grassland habitats of the Americas.
-
C.
Abital
Abital is one of the lesser-known wives of the biblical King David, mentioned in the Hebrew Bible as the mother of his son Shephatiah.
-
D.
BB-37
BB-37 is the hull number of USS Oklahoma, a Nevada-class battleship of the United States Navy that was sunk during the attack on Pearl Harbor in 1941.
-
E.
Neuralink
Neuralink is a neurotechnology company developing implantable brain–computer interfaces aimed at enabling direct communication between the human brain and computers.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Spinraza Target entity description: Spinraza is a prescription medication used to treat spinal muscular atrophy (SMA) by modifying SMN2 gene expression to increase production of survival motor neuron (SMN) protein.
-
A.
Pregny-Chambésy
Pregny-Chambésy is a small, affluent municipality on the shores of Lake Geneva in the canton of Geneva, Switzerland, known for hosting several international organizations and diplomatic missions.
-
B.
Philortyx
Philortyx is a genus of New World quails known for their ground-dwelling habits and occurrence in scrub and grassland habitats of the Americas.
-
C.
Abital
Abital is one of the lesser-known wives of the biblical King David, mentioned in the Hebrew Bible as the mother of his son Shephatiah.
-
D.
BB-37
BB-37 is the hull number of USS Oklahoma, a Nevada-class battleship of the United States Navy that was sunk during the attack on Pearl Harbor in 1941.
-
E.
Neuralink
Neuralink is a neurotechnology company developing implantable brain–computer interfaces aimed at enabling direct communication between the human brain and computers.
- F. None of above. chosen
Statements (49)
| Predicate | Object |
|---|---|
| instanceOf |
antisense oligonucleotide
ⓘ
biologic medicinal product ⓘ medication ⓘ orphan drug ⓘ prescription drug ⓘ |
| approvedBy |
European Medicines Agency
ⓘ
U.S. Food and Drug Administration ⓘ
linked to:
Food and Drug Administration
|
| developedBy |
Biogen
ⓘ
Ionis Pharmaceuticals ⓘ |
| hasActiveIngredient |
nusinersen
ⓘ
linked to:
Spinraza
|
| hasAdministrationSite | cerebrospinal fluid ⓘ |
| hasATCCode | M09AX07 ⓘ |
| hasBrandOwner | Biogen ⓘ |
| hasCommonAdverseEffect |
back pain
ⓘ
constipation ⓘ headache ⓘ nausea ⓘ respiratory infection ⓘ |
| hasDosageForm | solution for injection ⓘ |
| hasGenericName |
nusinersen
ⓘ
linked to:
Spinraza
|
| hasInternationalNonproprietaryName |
nusinersen
ⓘ
linked to:
Spinraza
|
| hasLoadingDoseRegimen | four loading doses over approximately two months ⓘ |
| hasMaintenanceDoseRegimen | one dose every four months ⓘ |
| hasPregnancyCategory | not assigned; use only if potential benefit justifies potential risk ⓘ |
| hasSeriousAdverseEffect |
coagulation abnormalities
ⓘ
renal toxicity ⓘ thrombocytopenia ⓘ |
| hasTherapeuticArea |
neurology
ⓘ
rare diseases ⓘ |
| increasesProductionOf |
SMN protein
ⓘ
linked to:
survival motor neuron protein
survival motor neuron protein ⓘ |
| indicatedFor |
adult patients with spinal muscular atrophy
ⓘ
pediatric patients with spinal muscular atrophy ⓘ |
| isAdministeredBy | healthcare professional ⓘ |
| isFirstDrugApprovedFor | spinal muscular atrophy ⓘ |
| isUsedAs | disease-modifying therapy for spinal muscular atrophy ⓘ |
| legalStatusInEuropeanUnion | prescription only ⓘ |
| legalStatusInUnitedStates | prescription only ⓘ |
| mechanismOfAction | antisense oligonucleotide that modulates SMN2 pre-mRNA splicing ⓘ |
| modifiesGeneExpression | SMN2 ⓘ |
| regulatoryApprovalYear | 2016 ⓘ |
| requiresMonitoringOf |
coagulation parameters
ⓘ
platelet count ⓘ renal function ⓘ |
| routeOfAdministration |
intrathecal
ⓘ
lumbar puncture ⓘ |
| targetsGene |
SMN2
ⓘ
linked to:
Spinraza
|
| treats |
5q spinal muscular atrophy
ⓘ
spinal muscular atrophy ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Spinraza Description of subject: Spinraza is a prescription medication used to treat spinal muscular atrophy (SMA) by modifying SMN2 gene expression to increase production of survival motor neuron (SMN) protein.
Referenced by (12)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Spinraza
linked to: Spinraza
linked to: Spinraza
linked to: Spinraza
linked to: Spinraza
linked to: Spinraza
linked to: Spinraza
linked to: Spinraza