Renflexis
E242409
Renflexis is a biosimilar version of the monoclonal antibody infliximab, used to treat autoimmune conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Renflexis canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T2190627 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Renflexis Context triple: [Remicade, hasBiosimilar, Renflexis]
-
A.
Echo Flex
Echo Flex is a compact, plug-in smart speaker from Amazon’s Echo line designed to provide Alexa voice assistant capabilities in small spaces like hallways, bathrooms, and kitchens.
-
B.
Fremulon
Fremulon is a television production company founded by Michael Schur, best known for producing acclaimed comedy series such as Brooklyn Nine-Nine.
-
C.
Versonnex
Versonnex is a small commune in the Ain department of eastern France, located near the Swiss border in the Pays de Gex region.
-
D.
REX
REX is a radio science experiment instrument aboard NASA's New Horizons spacecraft used to study the atmospheres and surfaces of planetary bodies through radio signal measurements.
-
E.
Ornex
Ornex is a small commune in the Ain department of eastern France, located near the Swiss border in the Pays de Gex region.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Renflexis Target entity description: Renflexis is a biosimilar version of the monoclonal antibody infliximab, used to treat autoimmune conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
-
A.
Echo Flex
Echo Flex is a compact, plug-in smart speaker from Amazon’s Echo line designed to provide Alexa voice assistant capabilities in small spaces like hallways, bathrooms, and kitchens.
-
B.
Fremulon
Fremulon is a television production company founded by Michael Schur, best known for producing acclaimed comedy series such as Brooklyn Nine-Nine.
-
C.
Versonnex
Versonnex is a small commune in the Ain department of eastern France, located near the Swiss border in the Pays de Gex region.
-
D.
REX
REX is a radio science experiment instrument aboard NASA's New Horizons spacecraft used to study the atmospheres and surfaces of planetary bodies through radio signal measurements.
-
E.
Ornex
Ornex is a small commune in the Ain department of eastern France, located near the Swiss border in the Pays de Gex region.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
biologic drug
ⓘ
biosimilar medicine ⓘ infliximab biosimilar ⓘ monoclonal antibody ⓘ |
| belongsToClass |
immunosuppressants
ⓘ
tumor necrosis factor alpha inhibitors ⓘ |
| hasApprovalType | biosimilar approval ⓘ |
| hasATCCode | L04AB02 ⓘ |
| hasBlackBoxWarning |
malignancy risk
ⓘ
serious infections ⓘ |
| hasDosageForm | intravenous infusion ⓘ |
| hasGenericName |
infliximab-abda
ⓘ
linked to:
Remicade
|
| hasMechanismOfAction | TNF-alpha inhibition ⓘ |
| hasMolecularType | chimeric monoclonal antibody ⓘ |
| hasReferenceProduct | Remicade ⓘ |
| hasRouteOfAdministration | intravenous ⓘ |
| hasSpeciesComponents | human-mouse chimeric antibody ⓘ |
| hasTarget |
TNF-alpha
ⓘ
linked to:
tumor necrosis factor alpha
|
| isAdministeredBy | healthcare professional ⓘ |
| isApprovedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
| isBiosimilarTo | infliximab ⓘ |
| isContraindicatedIn |
patients with moderate or severe heart failure
ⓘ
patients with severe hypersensitivity to infliximab ⓘ |
| isIndicatedFor |
active ankylosing spondylitis
ⓘ
active psoriatic arthritis ⓘ chronic severe plaque psoriasis ⓘ moderate to severe Crohn’s disease ⓘ moderate to severe rheumatoid arthritis ⓘ moderate to severe ulcerative colitis ⓘ pediatric Crohn’s disease ⓘ pediatric ulcerative colitis ⓘ |
| isIntendedFor |
adult patients
ⓘ
pediatric patients for certain indications ⓘ |
| isManufacturedBy | Samsung Bioepis ⓘ |
| isMarketedBy | Merck & Co. ⓘ |
| isUsedFor |
Crohn’s disease
ⓘ
ankylosing spondylitis ⓘ plaque psoriasis ⓘ psoriatic arthritis ⓘ rheumatoid arthritis ⓘ ulcerative colitis ⓘ |
| isUsedWith | methotrexate in rheumatoid arthritis ⓘ |
| mayCause |
immunogenicity
ⓘ
infusion-related reactions ⓘ |
| modulates | immune response ⓘ |
| reduces | inflammation ⓘ |
| targets | tumor necrosis factor alpha ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Renflexis Description of subject: Renflexis is a biosimilar version of the monoclonal antibody infliximab, used to treat autoimmune conditions such as rheumatoid arthritis, Crohn’s disease, and ulcerative colitis.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.