CASP (Critical Assessment of protein Structure Prediction)

E200554

community-wide experiment protein structure prediction benchmark scientific experiment

CASP (Critical Assessment of protein Structure Prediction) is a biennial community-wide experiment and benchmark that objectively evaluates and compares the accuracy of computational methods for predicting protein structures.

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All labels observed (7)

Label	Occurrences
Critical Assessment of protein Structure Prediction (CASP)	2
13th Critical Assessment of protein Structure Prediction	1
14th Critical Assessment of protein Structure Prediction	1
CASP (Critical Assessment of protein Structure Prediction) canonical	1
Critical Assessment of protein Structure Prediction	1
Critical Assessment of protein Structure Prediction conference	1
Protein Structure Prediction Center	1

How this entity was disambiguated

This entity first appeared as the object of triple T1793145 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: CASP (Critical Assessment of protein Structure Prediction)
Context triple: [AlphaFold, relatedTo, CASP (Critical Assessment of protein Structure Prediction)]

A. AlphaFold
AlphaFold is an artificial intelligence system developed by DeepMind that predicts protein 3D structures from amino acid sequences with unprecedented accuracy, revolutionizing structural biology.
B. Commission on Biological Macromolecules
The Commission on Biological Macromolecules is a specialist body within the International Union of Crystallography that promotes and coordinates research, standards, and collaboration in the crystallographic study of biological macromolecules such as proteins and nucleic acids.
C. Crystallographic Information Framework
The Crystallographic Information Framework is a standardized data format and ontology used worldwide for representing, exchanging, and archiving crystallographic and related structural science data.
D. CASS
CASS is the Cargo Accounts Settlement System, a global IATA-managed platform that streamlines and standardizes financial transactions between airlines and freight forwarders.
E. PEPM
PEPM (Partial Evaluation and Program Manipulation) is an ACM SIGPLAN-sponsored symposium focused on research in program analysis, transformation, and generation techniques.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: CASP (Critical Assessment of protein Structure Prediction)
Target entity description: CASP (Critical Assessment of protein Structure Prediction) is a biennial community-wide experiment and benchmark that objectively evaluates and compares the accuracy of computational methods for predicting protein structures.

A. AlphaFold
AlphaFold is an artificial intelligence system developed by DeepMind that predicts protein 3D structures from amino acid sequences with unprecedented accuracy, revolutionizing structural biology.
B. Commission on Biological Macromolecules
The Commission on Biological Macromolecules is a specialist body within the International Union of Crystallography that promotes and coordinates research, standards, and collaboration in the crystallographic study of biological macromolecules such as proteins and nucleic acids.
C. Crystallographic Information Framework
The Crystallographic Information Framework is a standardized data format and ontology used worldwide for representing, exchanging, and archiving crystallographic and related structural science data.
D. CASS
CASS is the Cargo Accounts Settlement System, a global IATA-managed platform that streamlines and standardizes financial transactions between airlines and freight forwarders.
E. PEPM
PEPM (Partial Evaluation and Program Manipulation) is an ACM SIGPLAN-sponsored symposium focused on research in program analysis, transformation, and generation techniques.
F. None of above. chosen

Statements (48)

Predicate	Object
instanceOf	community-wide experiment ⓘ protein structure prediction benchmark ⓘ scientific experiment ⓘ
acronym	CASP ⓘ linked to: CASP conference
evaluationBy	independent assessors ⓘ
evaluationCriterion	accuracy of predicted 3D protein structures ⓘ contact prediction accuracy ⓘ global fold accuracy ⓘ local structural accuracy ⓘ model quality estimation ⓘ
field	computational biology ⓘ protein structure prediction ⓘ structural bioinformatics ⓘ
frequency	biennial ⓘ
fullName	Critical Assessment of protein Structure Prediction ⓘ linked to: CASP (Critical Assessment of protein Structure Prediction)
hasCategory	RNA structure prediction ⓘ contact prediction ⓘ free modeling ⓘ model quality assessment ⓘ protein complex prediction ⓘ refinement ⓘ template-based modeling ⓘ
hasOutcome	guidance for future method development ⓘ identification of strengths and weaknesses of prediction approaches ⓘ ranking of participating prediction methods ⓘ
hostedBy	Protein Structure Prediction Center ⓘ linked to: CASP (Critical Assessment of protein Structure Prediction)
impact	accelerated progress in accurate protein structure prediction ⓘ provided benchmarks for deep learning-based structure prediction methods ⓘ
influenced	benchmarking standards in structural bioinformatics ⓘ development of protein structure prediction algorithms ⓘ machine learning methods for protein structure prediction ⓘ
knownFor	public release of prediction results and assessments ⓘ rigorous blind testing of prediction methods ⓘ setting community standards for protein structure prediction ⓘ
method	blind prediction assessment ⓘ use of unpublished experimental protein structures as targets ⓘ
organizer	John Moult ⓘ University of Maryland, Institute for Bioscience and Biotechnology Research ⓘ
purpose	comparison of computational protein structure prediction accuracy ⓘ objective evaluation of protein structure prediction methods ⓘ
relatedTo	protein structure determination by NMR spectroscopy ⓘ protein structure determination by X-ray crystallography ⓘ protein structure determination by cryo-electron microscopy ⓘ
startYear	1994 ⓘ
typicalParticipants	academic research groups ⓘ developers of protein structure prediction software ⓘ industry research groups ⓘ
website	https://predictioncenter.org ⓘ

How these facts were elicited