Guillain–Barré syndrome
E196711
acute inflammatory demyelinating polyradiculoneuropathy
autoimmune disease
neurological disorder
peripheral neuropathy
Guillain–Barré syndrome is an acute autoimmune disorder in which the immune system attacks peripheral nerves, leading to rapidly progressive muscle weakness and potential paralysis, often triggered by infections such as Campylobacter.
All labels observed (5)
| Label | Occurrences |
|---|---|
| Guillain–Barré syndrome canonical | 12 |
| Miller Fisher syndrome | 1 |
| acute inflammatory demyelinating polyradiculoneuropathy | 1 |
| acute motor and sensory axonal neuropathy | 1 |
| acute motor axonal neuropathy | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T1759109 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Guillain–Barré syndrome Context triple: [Campylobacter, complication, Guillain–Barré syndrome]
-
A.
spinal muscular atrophy
Spinal muscular atrophy is a genetic neuromuscular disorder characterized by progressive muscle weakness and atrophy due to degeneration of motor neurons in the spinal cord.
-
B.
ALS
ALS (amyotrophic lateral sclerosis) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and ultimately respiratory failure.
-
C.
relapsing-remitting multiple sclerosis
Relapsing-remitting multiple sclerosis is the most common form of multiple sclerosis, characterized by clearly defined attacks of neurological symptoms followed by periods of partial or complete recovery.
-
D.
progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy is a rare, often fatal demyelinating brain disease caused by reactivation of the JC virus in immunocompromised individuals, leading to rapidly progressive neurological decline.
-
E.
Leigh-Mallory
Leigh-Mallory is the surname of a prominent British military family, most notably borne by Air Chief Marshal Trafford Leigh-Mallory, a senior Royal Air Force commander during the Second World War.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Guillain–Barré syndrome Target entity description: Guillain–Barré syndrome is an acute autoimmune disorder in which the immune system attacks peripheral nerves, leading to rapidly progressive muscle weakness and potential paralysis, often triggered by infections such as Campylobacter.
-
A.
spinal muscular atrophy
Spinal muscular atrophy is a genetic neuromuscular disorder characterized by progressive muscle weakness and atrophy due to degeneration of motor neurons in the spinal cord.
-
B.
ALS
ALS (amyotrophic lateral sclerosis) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and ultimately respiratory failure.
-
C.
relapsing-remitting multiple sclerosis
Relapsing-remitting multiple sclerosis is the most common form of multiple sclerosis, characterized by clearly defined attacks of neurological symptoms followed by periods of partial or complete recovery.
-
D.
progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy is a rare, often fatal demyelinating brain disease caused by reactivation of the JC virus in immunocompromised individuals, leading to rapidly progressive neurological decline.
-
E.
Leigh-Mallory
Leigh-Mallory is the surname of a prominent British military family, most notably borne by Air Chief Marshal Trafford Leigh-Mallory, a senior Royal Air Force commander during the Second World War.
- F. None of above. chosen
Statements (66)
| Predicate | Object |
|---|---|
| instanceOf |
acute inflammatory demyelinating polyradiculoneuropathy
ⓘ
autoimmune disease ⓘ neurological disorder ⓘ peripheral neuropathy ⓘ |
| affectsSystem | peripheral nervous system ⓘ |
| canAffect | children ⓘ |
| hasCause | autoimmune attack on peripheral nerves ⓘ |
| hasClinicalCourse |
acute
ⓘ
monophasic ⓘ |
| hasComplication |
chronic neuropathic pain
ⓘ
deep vein thrombosis ⓘ paralysis ⓘ pulmonary embolism ⓘ respiratory failure ⓘ |
| hasDiagnosticFinding | albuminocytologic dissociation in cerebrospinal fluid ⓘ |
| hasDiagnosticTest |
electromyography
ⓘ
lumbar puncture ⓘ nerve conduction studies ⓘ |
| hasIncidence | about 1 to 2 cases per 100000 person-years ⓘ |
| hasMortalityRate | approximately 3–7 percent ⓘ |
| hasOnsetPattern | rapidly progressive ⓘ |
| hasPathophysiology |
immune-mediated axonal damage
ⓘ
immune-mediated demyelination of peripheral nerves ⓘ |
| hasPrimarySymptom |
areflexia
ⓘ
ascending muscle weakness ⓘ hyporeflexia ⓘ |
| hasPrognosis | most patients recover partially or completely ⓘ |
| hasSexDistribution | slightly more common in males ⓘ |
| hasSubtype |
Miller Fisher syndrome
ⓘ
linked to:
Guillain–Barré syndrome
acute inflammatory demyelinating polyradiculoneuropathy ⓘ
linked to:
Guillain–Barré syndrome
acute motor and sensory axonal neuropathy ⓘ
linked to:
Guillain–Barré syndrome
acute motor axonal neuropathy ⓘ
linked to:
Guillain–Barré syndrome
|
| hasSymptom |
autonomic dysfunction
ⓘ
blood pressure instability ⓘ bulbar weakness ⓘ cardiac arrhythmia ⓘ facial weakness ⓘ gait disturbance ⓘ numbness in extremities ⓘ paresthesia ⓘ respiratory muscle weakness ⓘ |
| hasSynonym |
GBS
ⓘ
acute inflammatory demyelinating polyneuropathy ⓘ |
| hasTreatment |
intravenous immunoglobulin
ⓘ
mechanical ventilation ⓘ physical rehabilitation ⓘ plasma exchange ⓘ supportive care ⓘ thromboprophylaxis ⓘ |
| hasTypicalAgeGroup | adults ⓘ |
| hasTypicalTrigger |
Campylobacter jejuni infection
ⓘ
Epstein–Barr virus infection ⓘ Mycoplasma pneumoniae infection ⓘ Zika virus infection ⓘ cytomegalovirus infection ⓘ gastrointestinal infection ⓘ infection ⓘ influenza infection ⓘ respiratory tract infection ⓘ surgery ⓘ vaccination ⓘ |
| isClassifiedUnder |
immune-mediated neuropathies
ⓘ
rare diseases ⓘ |
| wasFirstDescribedBy |
Georges Guillain
ⓘ
Jean Alexandre Barré ⓘ |
| wasFirstDescribedInYear | 1916 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Guillain–Barré syndrome Description of subject: Guillain–Barré syndrome is an acute autoimmune disorder in which the immune system attacks peripheral nerves, leading to rapidly progressive muscle weakness and potential paralysis, often triggered by infections such as Campylobacter.
Referenced by (16)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Guillain–Barré syndrome
linked to: Guillain–Barré syndrome
linked to: Guillain–Barré syndrome
linked to: Guillain–Barré syndrome