Luria–Delbrück experiment

E160513

The Luria–Delbrück experiment was a landmark 1943 study in bacterial genetics that demonstrated mutations arise randomly rather than in response to selective pressure, providing key evidence for the genetic basis of evolution.

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Statements (47)

Predicate Object
instanceOf bacterial genetics experiment ⓘ
fluctuation test ⓘ
scientific experiment ⓘ
analyzed distribution of resistant colonies across cultures ⓘ
contrastedWith Poisson distribution expected for induced mutations ⓘ
countryOfOrigin United States ⓘ
dataCharacteristic jackpot events of early mutations ⓘ
demonstrated mutations are not induced by selective pressure ⓘ
mutations arise randomly ⓘ
pre‑adaptive mutations ⓘ
field bacterial genetics ⓘ
evolutionary biology ⓘ
microbiology ⓘ
hasAlternativeName Luria–Delbrück fluctuation test ⓘ
fluctuation test ⓘ
hasAuthor Max Delbrück ⓘ
Salvador Luria ⓘ
hasImpactOn antibiotic resistance studies ⓘ
cancer mutation models ⓘ
influenced modern microbial genetics ⓘ
population genetics of mutation ⓘ
keyConcept bacteriophage resistance ⓘ
mutation rate estimation ⓘ
spontaneous mutation ⓘ
mainSubject bacterial mutation ⓘ
evolution ⓘ
random mutation ⓘ
measured number of phage‑resistant mutants per culture ⓘ
providedEvidenceFor Darwinian evolution ⓘ
genetic basis of evolution ⓘ
publicationYear 1943 ⓘ
publishedIn Genetics ⓘ
recognizedAs classic experiment in genetics ⓘ
landmark in molecular biology ⓘ
refuted Lamarckian inheritance in bacteria ⓘ
relatedConcept Darwinian selection ⓘ
linked to: Darwinism

Lamarckian adaptation ⓘ
linked to: Lamarckism

mutation-selection theory ⓘ
relatedTo Salvador Luria Nobel Prize in Physiology or Medicine 1969 ⓘ
showed high variance in number of resistant colonies ⓘ
supportsView mutations occur before exposure to selective agent ⓘ
testedOrganism Escherichia coli ⓘ
bacteriophage T1 ⓘ
timePeriod World War II era ⓘ
usedControl multiple independent bacterial cultures ⓘ
usedMethod fluctuation analysis ⓘ
statistical distribution of mutants ⓘ

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Referenced by (5)

Full triples — surface form annotated when it differs from this entity's canonical label.

Max Delbrück → knownFor → Luria–Delbrück experiment ⓘ
Salvador Luria → notableWork → Luria–Delbrück experiment ⓘ
Luria–Delbrück experiment → hasAlternativeName → Luria–Delbrück fluctuation test ⓘ
linked to: Luria–Delbrück experiment
Salvatore Luria → notableWork → Luria–Delbrück experiment ⓘ
subject linked to: Salvatore
Bacteriophage T1 → relatedTo → Luria–Delbrück fluctuation test ⓘ
subject linked to: bacteriophage T1
linked to: Luria–Delbrück experiment