edaravone
E133688
Edaravone is a neuroprotective drug used to slow functional decline in patients with amyotrophic lateral sclerosis (ALS).
All labels observed (1)
| Label | Occurrences |
|---|---|
| edaravone canonical | 9 |
How this entity was disambiguated
This entity first appeared as the object of triple T1169550 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: edaravone Context triple: [ALS, hasTreatment, edaravone]
-
A.
Dani Ardor
Dani Ardor is the emotionally traumatized American graduate student who becomes entangled with a sinister Swedish pagan cult in Ari Aster’s 2019 folk horror film "Midsommar."
-
B.
Varhadi
Varhadi is a regional dialect of Marathi spoken primarily in the Vidarbha region of Maharashtra, India, known for its distinct phonetic and lexical features.
-
C.
Audenarde
Audenarde (Oudenaarde) is a historic city in East Flanders, Belgium, known for its medieval architecture, tapestry production, and role in early modern European conflicts.
-
D.
Barellan
Barellan is a small rural town in the Riverina region of New South Wales, Australia, known for its grain farming and association with tennis champion Evonne Goolagong-Cawley.
-
E.
daric
The daric was a high-purity gold coin of the Achaemenid Persian Empire, widely used across its territories and influential in ancient Near Eastern and Greek economies.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: edaravone Target entity description: Edaravone is a neuroprotective drug used to slow functional decline in patients with amyotrophic lateral sclerosis (ALS).
-
A.
Dani Ardor
Dani Ardor is the emotionally traumatized American graduate student who becomes entangled with a sinister Swedish pagan cult in Ari Aster’s 2019 folk horror film "Midsommar."
-
B.
Varhadi
Varhadi is a regional dialect of Marathi spoken primarily in the Vidarbha region of Maharashtra, India, known for its distinct phonetic and lexical features.
-
C.
Audenarde
Audenarde (Oudenaarde) is a historic city in East Flanders, Belgium, known for its medieval architecture, tapestry production, and role in early modern European conflicts.
-
D.
Barellan
Barellan is a small rural town in the Riverina region of New South Wales, Australia, known for its grain farming and association with tennis champion Evonne Goolagong-Cawley.
-
E.
daric
The daric was a high-purity gold coin of the Achaemenid Persian Empire, widely used across its territories and influential in ancient Near Eastern and Greek economies.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
antioxidant
ⓘ
free radical scavenger ⓘ neuroprotective agent ⓘ pharmaceutical drug ⓘ small molecule ⓘ |
| approvedBy |
FDA
ⓘ
linked to:
Food and Drug Administration
U.S. Food and Drug Administration ⓘ
linked to:
Food and Drug Administration
|
| belongsToDrugClass |
free radical scavengers
ⓘ
neuroprotective drugs ⓘ |
| developedFor | treatment of amyotrophic lateral sclerosis ⓘ |
| eliminatedBy | kidney ⓘ |
| FDAApprovalYear | 2017 ⓘ |
| firstApprovedForALS | Japan ⓘ |
| firstApprovedForIndication | acute ischemic stroke in Japan ⓘ |
| hasATCCode | N07XX11 ⓘ |
| hasBlackBoxWarning | risk of hypersensitivity reactions including anaphylaxis (U.S.) ⓘ |
| hasBrandName |
Radicava
ⓘ
Radicava ORS ⓘ Radicut ⓘ |
| hasCASNumber | 89-25-8 ⓘ |
| hasChemicalFormula | C10H10N2O ⓘ |
| hasCommonAdverseEffect |
contusion
ⓘ
eczema ⓘ gait disturbance ⓘ headache ⓘ respiratory failure ⓘ |
| hasEliminationHalfLife | approximately 4.5 to 6 hours (intravenous) ⓘ |
| hasIUPACName | 3-methyl-1-phenyl-2-pyrazolin-5-one ⓘ |
| hasLegalStatus | prescription-only medicine ⓘ |
| hasMechanismOfAction |
reduces oxidative stress
ⓘ
scavenges free radicals ⓘ |
| hasMolarMass | 174.20 g/mol ⓘ |
| hasPharmacologicalAction | neuroprotection in motor neurons ⓘ |
| hasPregnancyCategory | not well established in humans ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ |
| hasSeriousAdverseEffect |
anaphylaxis
ⓘ
hypersensitivity reactions ⓘ |
| hasTargetPopulation | adult patients with ALS ⓘ |
| hasTherapeuticEffect | slows functional decline in ALS patients ⓘ |
| indication | treatment of ALS in adults ⓘ |
| isAdministeredOnSchedule | cyclic dosing regimen for ALS ⓘ |
| isContraindicatedIn |
patients with history of hypersensitivity to edaravone
ⓘ
patients with sulfite hypersensitivity (for some formulations) ⓘ |
| metabolizedBy | liver ⓘ |
| treats |
ALS
ⓘ
amyotrophic lateral sclerosis ⓘ |
| wasFirstApprovedIn | Japan ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: edaravone Description of subject: Edaravone is a neuroprotective drug used to slow functional decline in patients with amyotrophic lateral sclerosis (ALS).
Referenced by (9)
Full triples — surface form annotated when it differs from this entity's canonical label.