TARDBP
E133685
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
All labels observed (4)
| Label | Occurrences |
|---|---|
| TAR DNA-binding protein 43 | 1 |
| TARDBP canonical | 1 |
| TDP-43 | 1 |
| transactive response DNA-binding protein 43 kDa | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T1169536 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: TARDBP Context triple: [ALS, associatedWithGene, TARDBP]
-
A.
DPPA
DPPA is the United Nations department responsible for conflict prevention, peacemaking, and supporting political and peacebuilding efforts worldwide.
-
B.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
C.
TPA
TPA is an abbreviation commonly used for a Tri-Party Agreement, a legal contract involving three separate parties that defines their respective rights and obligations.
-
D.
PZPR
PZPR was the ruling communist party that governed the Polish People's Republic from the late 1940s until the fall of communism in 1989.
-
E.
AGAT
AGAT is a Polish special forces unit known for high-risk direct action, counterterrorism, and rapid response operations.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: TARDBP Target entity description: TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
-
A.
DPPA
DPPA is the United Nations department responsible for conflict prevention, peacemaking, and supporting political and peacebuilding efforts worldwide.
-
B.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
C.
TPA
TPA is an abbreviation commonly used for a Tri-Party Agreement, a legal contract involving three separate parties that defines their respective rights and obligations.
-
D.
PZPR
PZPR was the ruling communist party that governed the Polish People's Republic from the late 1940s until the fall of communism in 1989.
-
E.
AGAT
AGAT is a Polish special forces unit known for high-risk direct action, counterterrorism, and rapid response operations.
- F. None of above. chosen
Statements (51)
| Predicate | Object |
|---|---|
| instanceOf |
human gene
ⓘ
protein-coding gene ⓘ |
| associatedWithDisease |
ALS
ⓘ
ALS-FTD spectrum disorders ⓘ amyotrophic lateral sclerosis ⓘ frontotemporal dementia ⓘ frontotemporal lobar degeneration ⓘ |
| associatedWithPathology |
TDP-43 proteinopathy
ⓘ
cytoplasmic TDP-43 inclusions ⓘ neuronal TDP-43 aggregates ⓘ |
| encodes |
TAR DNA-binding protein 43
ⓘ
linked to:
TARDBP
TDP-43 ⓘ
linked to:
TARDBP
transactive response DNA-binding protein 43 kDa ⓘ
linked to:
TARDBP
|
| expressedIn |
central nervous system
ⓘ
motor neurons ⓘ ubiquitous tissues ⓘ |
| hasBiologicalProcess |
RNA metabolism
ⓘ
alternative splicing ⓘ axon maintenance ⓘ neuronal survival ⓘ pre-mRNA splicing ⓘ stress granule dynamics ⓘ transcriptional repression ⓘ |
| hasMolecularFunction |
DNA binding
ⓘ
RNA binding ⓘ RNA splicing regulation ⓘ mRNA stability regulation ⓘ microRNA biogenesis regulation ⓘ transcription regulation ⓘ |
| hasProteinFeature |
RNA recognition motif
ⓘ
RRM1 domain ⓘ RRM2 domain ⓘ glycine-rich C-terminal domain ⓘ nuclear export signal ⓘ nuclear localization signal ⓘ prion-like domain ⓘ |
| involvedIn |
RNA transport
ⓘ
formation of ribonucleoprotein granules ⓘ stress response ⓘ |
| locatedOnChromosome | chromosome 1 ⓘ |
| locatedOnChromosomeArm | 1p ⓘ |
| mutationAssociatedWith |
familial ALS
ⓘ
sporadic ALS ⓘ |
| mutationType |
frameshift mutation
ⓘ
missense mutation ⓘ nonsense mutation ⓘ |
| orthologInSpecies |
mouse Tardbp
ⓘ
zebrafish tardbp ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
nucleus ⓘ stress granules ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: TARDBP Description of subject: TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.