Cancer, Ageing and Somatic Mutation
E890467
ageing research programme
cancer research programme
research programme
scientific research programme
Cancer, Ageing and Somatic Mutation is a research programme that investigates how genetic changes in cells drive cancer development and the biological processes of ageing.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Cancer, Ageing and Somatic Mutation canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10882251 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Cancer, Ageing and Somatic Mutation Context triple: [Wellcome Sanger Institute, hasResearchProgramme, Cancer, Ageing and Somatic Mutation]
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A.
Molecular Markers, Natural History and Evolution
Molecular Markers, Natural History and Evolution is a foundational book in evolutionary biology that explains how molecular genetic markers are used to study natural populations, phylogeny, and evolutionary processes.
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B.
Centre for Cancer Biomarkers
The Centre for Cancer Biomarkers is a research center focused on discovering, validating, and applying biomarkers to improve the diagnosis, prognosis, and treatment of cancer.
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C.
Cancer Discovery
Cancer Discovery is a leading peer-reviewed scientific journal that publishes cutting-edge research and clinical studies in oncology.
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D.
Division of Cancer Epidemiology and Genetics
The Division of Cancer Epidemiology and Genetics is a research branch of the U.S. National Cancer Institute that investigates the causes, distribution, and genetic factors of cancer in human populations.
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E.
Theories of Ageing
Theories of Ageing is an influential work in evolutionary biology that examines and explains the mechanisms and evolutionary basis of aging in organisms.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Cancer, Ageing and Somatic Mutation Target entity description: Cancer, Ageing and Somatic Mutation is a research programme that investigates how genetic changes in cells drive cancer development and the biological processes of ageing.
-
A.
Molecular Markers, Natural History and Evolution
Molecular Markers, Natural History and Evolution is a foundational book in evolutionary biology that explains how molecular genetic markers are used to study natural populations, phylogeny, and evolutionary processes.
-
B.
Centre for Cancer Biomarkers
The Centre for Cancer Biomarkers is a research center focused on discovering, validating, and applying biomarkers to improve the diagnosis, prognosis, and treatment of cancer.
-
C.
Cancer Discovery
Cancer Discovery is a leading peer-reviewed scientific journal that publishes cutting-edge research and clinical studies in oncology.
-
D.
Division of Cancer Epidemiology and Genetics
The Division of Cancer Epidemiology and Genetics is a research branch of the U.S. National Cancer Institute that investigates the causes, distribution, and genetic factors of cancer in human populations.
-
E.
Theories of Ageing
Theories of Ageing is an influential work in evolutionary biology that examines and explains the mechanisms and evolutionary basis of aging in organisms.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
ageing research programme
ⓘ
cancer research programme ⓘ research programme ⓘ scientific research programme ⓘ |
| aimsTo |
understand how somatic mutations accumulate in tissues
ⓘ
understand how somatic mutations contribute to ageing ⓘ understand how somatic mutations contribute to cancer ⓘ |
| examines |
how somatic evolution changes with age
ⓘ
how somatic evolution differs between tissues ⓘ interplay between somatic mutation and tissue microenvironment ⓘ |
| focusesOn |
ageing
ⓘ
cancer ⓘ somatic mutation ⓘ |
| goal |
identify mechanisms that maintain genome integrity in somatic cells
ⓘ
identify mechanisms whose failure accelerates ageing ⓘ identify mechanisms whose failure leads to cancer ⓘ link somatic mutation burden to ageing phenotypes ⓘ link somatic mutation burden to cancer risk ⓘ |
| investigates |
cellular mechanisms of DNA damage
ⓘ
cellular mechanisms of DNA repair ⓘ how cell lineages expand in tissues ⓘ how clonal expansions relate to cancer risk ⓘ mutation patterns in cancer ⓘ mutation patterns in normal tissues ⓘ |
| relatedTo |
cancer biology
ⓘ
cell biology ⓘ evolutionary biology ⓘ gerontology ⓘ molecular biology ⓘ |
| researchArea |
age-related disease
ⓘ
cancer genomics ⓘ clonal evolution ⓘ genomics ⓘ somatic mutation landscapes ⓘ tissue homeostasis ⓘ |
| studies |
age-related changes in tissue architecture
ⓘ
biological processes of ageing ⓘ cellular evolution over the human lifespan ⓘ early events in tumorigenesis ⓘ genetic changes in cells ⓘ how environmental exposures shape somatic mutation ⓘ how genetic changes drive cancer development ⓘ mutational signatures in tissues ⓘ |
| usesMethod |
bioinformatics analysis
ⓘ
computational modelling of evolution in tissues ⓘ genome sequencing ⓘ somatic mutation profiling ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Cancer, Ageing and Somatic Mutation Description of subject: Cancer, Ageing and Somatic Mutation is a research programme that investigates how genetic changes in cells drive cancer development and the biological processes of ageing.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.