Hill–Robertson interference
E879131
Hill–Robertson interference is an evolutionary genetics concept describing how linkage between loci in finite populations reduces the efficiency of natural selection by causing beneficial and deleterious mutations to interfere with each other's fixation.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Hill–Robertson interference canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10687996 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Hill–Robertson interference Context triple: [Brian Charlesworth, researchFocus, Hill–Robertson interference]
-
A.
Dobzhansky–Muller incompatibilities
Dobzhansky–Muller incompatibilities are genetic conflicts between interacting genes that evolve in separate populations, causing reduced fitness or sterility in their hybrids and thereby contributing to reproductive isolation and speciation.
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B.
Lewontin’s paradox of variation
Lewontin’s paradox of variation is an evolutionary genetics puzzle highlighting that genetic diversity within species varies far less than expected from differences in their population sizes.
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C.
Haldane’s cost of selection
Haldane’s cost of selection is a population genetics concept quantifying the reproductive burden and time required for natural selection to replace one gene variant with a fitter alternative in a population.
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D.
Evolution in Mendelian Populations
"Evolution in Mendelian Populations" is a foundational 1931 paper by Sewall Wright that introduced key concepts of population genetics, including genetic drift, inbreeding, and the shifting balance theory of evolution.
-
E.
Genetics of the Evolutionary Process
Genetics of the Evolutionary Process is a seminal work in evolutionary biology that synthesizes genetic principles with natural selection to explain how evolutionary change occurs within and between populations.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Hill–Robertson interference Target entity description: Hill–Robertson interference is an evolutionary genetics concept describing how linkage between loci in finite populations reduces the efficiency of natural selection by causing beneficial and deleterious mutations to interfere with each other's fixation.
-
A.
Dobzhansky–Muller incompatibilities
Dobzhansky–Muller incompatibilities are genetic conflicts between interacting genes that evolve in separate populations, causing reduced fitness or sterility in their hybrids and thereby contributing to reproductive isolation and speciation.
-
B.
Lewontin’s paradox of variation
Lewontin’s paradox of variation is an evolutionary genetics puzzle highlighting that genetic diversity within species varies far less than expected from differences in their population sizes.
-
C.
Haldane’s cost of selection
Haldane’s cost of selection is a population genetics concept quantifying the reproductive burden and time required for natural selection to replace one gene variant with a fitter alternative in a population.
-
D.
Evolution in Mendelian Populations
"Evolution in Mendelian Populations" is a foundational 1931 paper by Sewall Wright that introduced key concepts of population genetics, including genetic drift, inbreeding, and the shifting balance theory of evolution.
-
E.
Genetics of the Evolutionary Process
Genetics of the Evolutionary Process is a seminal work in evolutionary biology that synthesizes genetic principles with natural selection to explain how evolutionary change occurs within and between populations.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf | evolutionary genetics concept ⓘ |
| appliesTo |
asexual populations
ⓘ
diploid populations ⓘ haploid populations ⓘ sexual populations ⓘ |
| consequence |
reduced effective population size for selected loci
ⓘ
selection on one locus affects response at another linked locus ⓘ |
| context | linkage disequilibrium among selected sites ⓘ |
| describes |
interference among selected loci in finite populations
ⓘ
reduction in efficiency of natural selection due to linkage ⓘ |
| effect |
increased fixation probability of deleterious mutations
ⓘ
increased genetic draft ⓘ reduced adaptive evolution ⓘ reduced efficacy of natural selection ⓘ reduced fixation probability of beneficial mutations ⓘ |
| field |
evolutionary biology
ⓘ
population genetics ⓘ |
| involves |
beneficial mutations
ⓘ
deleterious mutations ⓘ finite population size ⓘ genetic drift ⓘ genetic linkage ⓘ linkage between loci ⓘ recombination ⓘ |
| mechanism |
competition among linked beneficial alleles
ⓘ
hitchhiking of deleterious alleles with beneficial alleles ⓘ stochastic associations between loci due to drift ⓘ |
| mitigatedBy |
increased recombination rate
ⓘ
recombination ⓘ |
| moreSevereIn |
regions of low recombination
ⓘ
small populations ⓘ tightly linked loci ⓘ |
| namedAfter |
Alan Robertson
ⓘ
William G. Hill NERFINISHED ⓘ |
| originallyDescribedIn | paper on linkage and selection in finite populations ⓘ |
| proposedBy |
Alan Robertson
ⓘ
William G. Hill NERFINISHED ⓘ |
| publicationYear | 1966 ⓘ |
| relatedTo |
Muller’s ratchet
ⓘ
linked to:
Muller's ratchet
background selection ⓘ clonal interference ⓘ genetic draft ⓘ selective sweeps ⓘ |
| supports | selection for higher recombination rates ⓘ |
| usedIn |
interpretation of patterns of genetic diversity
ⓘ
models of genome evolution ⓘ theory of evolution of recombination ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Hill–Robertson interference Description of subject: Hill–Robertson interference is an evolutionary genetics concept describing how linkage between loci in finite populations reduces the efficiency of natural selection by causing beneficial and deleterious mutations to interfere with each other's fixation.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.