From Genes to Systems: The Evolving Paradigm in Biology
E824760
"From Genes to Systems: The Evolving Paradigm in Biology" is a work by physiologist Denis Noble that argues for a shift from gene-centered views of life toward an integrative, systems-level understanding of biological organization and function.
All labels observed (1)
| Label | Occurrences |
|---|---|
| From Genes to Systems: The Evolving Paradigm in Biology canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T9844978 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: From Genes to Systems: The Evolving Paradigm in Biology Context triple: [Denis Noble, notableWork, From Genes to Systems: The Evolving Paradigm in Biology]
-
A.
The Future of Biology
"The Future of Biology" is an essay by David Lewis that explores how advances in biological science might reshape our understanding of life, mind, and philosophical questions about possibility and explanation.
-
B.
The Triple Helix: Gene, Organism, and Environment
The Triple Helix: Gene, Organism, and Environment is a book by evolutionary biologist Richard Lewontin that critiques genetic determinism and emphasizes the dynamic, reciprocal interactions among genes, organisms, and their environments in shaping biological traits.
-
C.
The Growth of Biological Thought
The Growth of Biological Thought is a landmark 1982 book by evolutionary biologist Ernst Mayr that traces the historical development and conceptual foundations of modern biology, especially evolutionary theory and systematics.
-
D.
Molecular Systems Biology
Molecular Systems Biology is a peer-reviewed scientific journal focusing on systems-level analysis of molecular and cellular processes in biology.
-
E.
Biological Systems Science
Biological Systems Science is a research subprogram that investigates the structure, function, and interactions of living systems, often using systems biology and omics approaches to understand and predict biological behavior.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: From Genes to Systems: The Evolving Paradigm in Biology Target entity description: "From Genes to Systems: The Evolving Paradigm in Biology" is a work by physiologist Denis Noble that argues for a shift from gene-centered views of life toward an integrative, systems-level understanding of biological organization and function.
-
A.
The Future of Biology
"The Future of Biology" is an essay by David Lewis that explores how advances in biological science might reshape our understanding of life, mind, and philosophical questions about possibility and explanation.
-
B.
The Triple Helix: Gene, Organism, and Environment
The Triple Helix: Gene, Organism, and Environment is a book by evolutionary biologist Richard Lewontin that critiques genetic determinism and emphasizes the dynamic, reciprocal interactions among genes, organisms, and their environments in shaping biological traits.
-
C.
The Growth of Biological Thought
The Growth of Biological Thought is a landmark 1982 book by evolutionary biologist Ernst Mayr that traces the historical development and conceptual foundations of modern biology, especially evolutionary theory and systematics.
-
D.
Molecular Systems Biology
Molecular Systems Biology is a peer-reviewed scientific journal focusing on systems-level analysis of molecular and cellular processes in biology.
-
E.
Biological Systems Science
Biological Systems Science is a research subprogram that investigates the structure, function, and interactions of living systems, often using systems biology and omics approaches to understand and predict biological behavior.
- F. None of above. chosen
Statements (44)
| Predicate | Object |
|---|---|
| instanceOf |
book
ⓘ
scientific work ⓘ |
| addresses |
conceptual change in modern biology
ⓘ
relationship between genes and higher-level functions ⓘ systems-level explanations of phenotype ⓘ |
| arguesAgainst | strict gene-centric reductionism ⓘ |
| arguesFor |
importance of physiological context for gene function
ⓘ
multi-level causation in biology ⓘ top-down as well as bottom-up causation ⓘ view of genes as components within regulatory networks ⓘ |
| author | Denis Noble ⓘ |
| contributor | Denis Noble ⓘ |
| emphasizes |
context-dependence of gene action
ⓘ
dynamic interactions among biological components ⓘ importance of organization and structure in living systems ⓘ |
| field |
biology
ⓘ
physiology ⓘ systems biology ⓘ |
| focusesOn |
feedback and regulation in biological systems
ⓘ
integration of experimental and computational approaches ⓘ network-based explanations of function ⓘ role of higher-level organization in controlling genes ⓘ shift from gene-centered to systems-level perspectives ⓘ |
| genre |
non-fiction
ⓘ
scientific literature ⓘ |
| language | English ⓘ |
| mainTopic |
biological networks
ⓘ
causation in biological systems ⓘ conceptual foundations of systems biology ⓘ critique of gene-centered views of life ⓘ dynamic systems in biology ⓘ emergent properties in biology ⓘ integration of molecular and organismal levels ⓘ integrative biology ⓘ limitations of genetic determinism ⓘ multi-level biological organization ⓘ multi-scale modeling in biology ⓘ philosophy of biology ⓘ systems approaches to physiology ⓘ systems-level understanding of biological organization ⓘ |
| perspectiveOf | physiologist ⓘ |
| relatedTo |
The Music of Life
ⓘ
integrative systems biology ⓘ systems physiology ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: From Genes to Systems: The Evolving Paradigm in Biology Description of subject: "From Genes to Systems: The Evolving Paradigm in Biology" is a work by physiologist Denis Noble that argues for a shift from gene-centered views of life toward an integrative, systems-level understanding of biological organization and function.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.