RNA world hypothesis
E725896
The RNA world hypothesis proposes that early life on Earth was based on self-replicating RNA molecules that both stored genetic information and catalyzed chemical reactions before the evolution of DNA and proteins.
All labels observed (1)
| Label | Occurrences |
|---|---|
| RNA world hypothesis canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T8321406 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: RNA world hypothesis Context triple: [Haldane–Oparin hypothesis of the origin of life, relatedConcept, RNA world hypothesis]
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A.
Haldane–Oparin hypothesis of the origin of life
The Haldane–Oparin hypothesis of the origin of life proposes that life first arose through a gradual chemical evolution of organic molecules in Earth’s early “primordial soup,” eventually leading to self-replicating systems.
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B.
The Origin of Life
The Origin of Life is a seminal 1967 scientific work by John Desmond Bernal that explores hypotheses on how life first emerged from non-living matter on Earth.
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C.
Origins of Life (book)
"Origins of Life" is a scientific book by physicist and mathematician Freeman Dyson that explores theoretical scenarios for how life might have first emerged from nonliving matter.
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D.
The Language of Life
The Language of Life is a popular science book by geneticist Francis Collins that explains how advances in genomics are transforming medicine and personal health.
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E.
Szostak Design
Szostak Design is an architectural firm known for designing prominent cultural and performing arts venues, including the Durham Performing Arts Center in North Carolina.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: RNA world hypothesis Target entity description: The RNA world hypothesis proposes that early life on Earth was based on self-replicating RNA molecules that both stored genetic information and catalyzed chemical reactions before the evolution of DNA and proteins.
-
A.
Haldane–Oparin hypothesis of the origin of life
The Haldane–Oparin hypothesis of the origin of life proposes that life first arose through a gradual chemical evolution of organic molecules in Earth’s early “primordial soup,” eventually leading to self-replicating systems.
-
B.
The Origin of Life
The Origin of Life is a seminal 1967 scientific work by John Desmond Bernal that explores hypotheses on how life first emerged from non-living matter on Earth.
-
C.
Origins of Life (book)
"Origins of Life" is a scientific book by physicist and mathematician Freeman Dyson that explores theoretical scenarios for how life might have first emerged from nonliving matter.
-
D.
The Language of Life
The Language of Life is a popular science book by geneticist Francis Collins that explains how advances in genomics are transforming medicine and personal health.
-
E.
Szostak Design
Szostak Design is an architectural firm known for designing prominent cultural and performing arts venues, including the Durham Performing Arts Center in North Carolina.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf | scientific hypothesis ⓘ |
| addresses |
how life originated from non-living chemistry
ⓘ
transition from prebiotic chemistry to biological evolution ⓘ |
| associatedWith | Walter Gilbert ⓘ |
| basedOn |
ability of RNA to store genetic information
ⓘ
dual role of RNA as information carrier and catalyst ⓘ existence of catalytic RNA (ribozymes) ⓘ |
| coinedBy | Walter Gilbert ⓘ |
| coinedIn | 1986 ⓘ |
| contrastedWith |
lipid world hypothesis
ⓘ
metabolism-first hypotheses ⓘ protein-first hypotheses ⓘ |
| field |
abiogenesis
ⓘ
biochemistry ⓘ evolutionary biology ⓘ molecular biology ⓘ |
| implies |
an early stage of life with RNA genomes
ⓘ
modern DNA–RNA–protein system evolved from an earlier RNA-based system ⓘ proteins and DNA evolved later than RNA ⓘ |
| influences |
experimental research on prebiotic RNA synthesis
ⓘ
models of early evolution and genetic systems ⓘ studies of minimal self-replicating systems ⓘ |
| openQuestion |
how RNA replication without enzymes was achieved
ⓘ
how long RNA genomes could remain stable in early Earth conditions ⓘ how prebiotic synthesis of ribonucleotides occurred ⓘ how proteins became the dominant biological catalysts ⓘ how the transition from RNA genomes to DNA genomes occurred ⓘ |
| proposes |
RNA molecules once catalyzed chemical reactions
ⓘ
RNA molecules once performed roles now carried out by both DNA and proteins ⓘ RNA molecules once stored genetic information ⓘ RNA preceded DNA and proteins in biological evolution ⓘ early life on Earth was based on RNA ⓘ self-replicating RNA molecules existed before cells with DNA genomes ⓘ |
| publishedIn | Nature ⓘ |
| relatedConcept |
DNA world
ⓘ
central dogma of molecular biology ⓘ prebiotic chemistry ⓘ protein world ⓘ protocell ⓘ ribosome ⓘ ribozymes ⓘ self-replicating molecules ⓘ |
| supportedBy |
catalytic activity of the ribosome’s rRNA
ⓘ
central role of RNA in translation ⓘ discovery of ribozymes ⓘ in vitro selection of self-ligating and self-cleaving RNAs ⓘ laboratory evolution of catalytic RNAs ⓘ presence of RNA cofactors such as ATP and NAD+ ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: RNA world hypothesis Description of subject: The RNA world hypothesis proposes that early life on Earth was based on self-replicating RNA molecules that both stored genetic information and catalyzed chemical reactions before the evolution of DNA and proteins.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.