Bohr effect
E442121
The Bohr effect is a physiological phenomenon in which increases in carbon dioxide concentration and acidity reduce hemoglobin’s affinity for oxygen, thereby facilitating oxygen release to tissues.
All labels observed (2)
| Label | Occurrences |
|---|---|
| Bohr effect canonical | 2 |
| Houssay phenomenon | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4457145 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Bohr effect Context triple: [Christian Bohr, notableWork, Bohr effect]
-
A.
Behring
Behring is a German surname most notably associated with Emil Adolf von Behring, the pioneering physiologist and first Nobel laureate in Physiology or Medicine for his work on serum therapy.
-
B.
Farrer hypothesis
The Farrer hypothesis is a theory of New Testament source criticism that proposes the Gospel of Mark was written first, Matthew used Mark, and Luke used both Mark and Matthew, thereby dispensing with the need for a separate Q source.
-
C.
Nernst equation
The Nernst equation is a fundamental electrochemistry formula that relates the reduction potential of a half-cell to the standard electrode potential, temperature, and activities (or concentrations) of the chemical species involved.
-
D.
Neebe
Neebe is a surname most notably associated with Oscar Neebe, an American labor activist and one of the defendants in the 1886 Haymarket affair.
-
E.
Rubin–Ford effect
The Rubin–Ford effect is an observed large-scale motion of galaxies relative to the cosmic microwave background that provided early evidence for peculiar velocities and inhomogeneities in the universe’s expansion.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Bohr effect Target entity description: The Bohr effect is a physiological phenomenon in which increases in carbon dioxide concentration and acidity reduce hemoglobin’s affinity for oxygen, thereby facilitating oxygen release to tissues.
-
A.
Behring
Behring is a German surname most notably associated with Emil Adolf von Behring, the pioneering physiologist and first Nobel laureate in Physiology or Medicine for his work on serum therapy.
-
B.
Farrer hypothesis
The Farrer hypothesis is a theory of New Testament source criticism that proposes the Gospel of Mark was written first, Matthew used Mark, and Luke used both Mark and Matthew, thereby dispensing with the need for a separate Q source.
-
C.
Nernst equation
The Nernst equation is a fundamental electrochemistry formula that relates the reduction potential of a half-cell to the standard electrode potential, temperature, and activities (or concentrations) of the chemical species involved.
-
D.
Neebe
Neebe is a surname most notably associated with Oscar Neebe, an American labor activist and one of the defendants in the 1886 Haymarket affair.
-
E.
Rubin–Ford effect
The Rubin–Ford effect is an observed large-scale motion of galaxies relative to the cosmic microwave background that provided early evidence for peculiar velocities and inhomogeneities in the universe’s expansion.
- F. None of above. chosen
Statements (42)
| Predicate | Object |
|---|---|
| instanceOf |
hemoglobin-oxygen binding effect
ⓘ
physiological phenomenon ⓘ |
| affects | hemoglobin ⓘ |
| category |
hematology concept
ⓘ
respiratory physiology concept ⓘ |
| contrastedWith | Haldane effect ⓘ |
| dependsOn |
2,3-bisphosphoglycerate concentration
ⓘ
pH ⓘ partial pressure of carbon dioxide ⓘ temperature ⓘ |
| describes |
decrease in hemoglobin oxygen affinity with decreasing pH
ⓘ
decrease in hemoglobin oxygen affinity with increasing carbon dioxide ⓘ |
| discoveredBy | Christian Bohr ⓘ |
| enhances | matching of oxygen supply to tissue demand ⓘ |
| historicalDiscoveryYear | 1904 ⓘ |
| importantFor |
oxygen delivery during exercise
ⓘ
oxygen delivery to metabolically active tissues ⓘ |
| influencedBy | metabolic activity of tissues ⓘ |
| involvesMolecule |
carbon dioxide
ⓘ
hemoglobin A ⓘ hydrogen ion ⓘ oxygen ⓘ |
| lessPronouncedIn | pulmonary capillaries ⓘ |
| mechanismInvolves |
formation of carbaminohemoglobin
ⓘ
increased carbon dioxide concentration ⓘ increased hydrogen ion concentration ⓘ protonation of hemoglobin ⓘ stabilization of deoxyhemoglobin ⓘ |
| morePronouncedIn | systemic capillaries ⓘ |
| namedAfter | Christian Bohr ⓘ |
| occursIn |
blood
ⓘ
humans ⓘ vertebrates ⓘ |
| relatedTo |
acid-base balance
ⓘ
carbon dioxide transport ⓘ oxygen-hemoglobin dissociation curve ⓘ |
| relevance |
anesthesiology
ⓘ
clinical medicine ⓘ critical care medicine ⓘ respiratory physiology ⓘ |
| resultsIn |
facilitated oxygen release to tissues
ⓘ
rightward shift of oxygen-hemoglobin dissociation curve ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Bohr effect Description of subject: The Bohr effect is a physiological phenomenon in which increases in carbon dioxide concentration and acidity reduce hemoglobin’s affinity for oxygen, thereby facilitating oxygen release to tissues.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Bohr effect