congenital Zika syndrome
E419030
Congenital Zika syndrome is a pattern of birth defects, including severe microcephaly and brain, eye, and joint abnormalities, that occurs in infants exposed to Zika virus during pregnancy.
All labels observed (1)
| Label | Occurrences |
|---|---|
| congenital Zika syndrome canonical | 2 |
How this entity was disambiguated
This entity first appeared as the object of triple T4200529 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: congenital Zika syndrome Context triple: [2015–2016 Zika virus outbreak, associatedWith, congenital Zika syndrome]
-
A.
2015–2016 Zika virus outbreak
The 2015–2016 Zika virus outbreak was a major global health crisis, centered in the Americas, marked by mosquito-borne transmission and severe birth defects such as microcephaly, prompting international public health emergencies and coordinated responses.
-
B.
Dyskolos
Dyskolos is an ancient Greek comedy by the playwright Menander, renowned as one of the best-preserved examples of New Comedy.
-
C.
progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy is a rare, often fatal demyelinating brain disease caused by reactivation of the JC virus in immunocompromised individuals, leading to rapidly progressive neurological decline.
-
D.
Tshilamoya
Tshilamoya is the popular nickname of Highlanders F.C., one of Zimbabwe’s oldest and most successful football clubs.
-
E.
CV-2
CV-2 refers to the Imperial Japanese Navy aircraft carrier Hiryū, a key fleet carrier that participated in major early Pacific War battles before being sunk at Midway in 1942.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: congenital Zika syndrome Target entity description: Congenital Zika syndrome is a pattern of birth defects, including severe microcephaly and brain, eye, and joint abnormalities, that occurs in infants exposed to Zika virus during pregnancy.
-
A.
2015–2016 Zika virus outbreak
The 2015–2016 Zika virus outbreak was a major global health crisis, centered in the Americas, marked by mosquito-borne transmission and severe birth defects such as microcephaly, prompting international public health emergencies and coordinated responses.
-
B.
Dyskolos
Dyskolos is an ancient Greek comedy by the playwright Menander, renowned as one of the best-preserved examples of New Comedy.
-
C.
progressive multifocal leukoencephalopathy
Progressive multifocal leukoencephalopathy is a rare, often fatal demyelinating brain disease caused by reactivation of the JC virus in immunocompromised individuals, leading to rapidly progressive neurological decline.
-
D.
Tshilamoya
Tshilamoya is the popular nickname of Highlanders F.C., one of Zimbabwe’s oldest and most successful football clubs.
-
E.
CV-2
CV-2 refers to the Imperial Japanese Navy aircraft carrier Hiryū, a key fleet carrier that participated in major early Pacific War battles before being sunk at Midway in 1942.
- F. None of above. chosen
Statements (48)
| Predicate | Object |
|---|---|
| instanceOf |
congenital disorder
ⓘ
neurodevelopmental disorder ⓘ teratogenic syndrome ⓘ |
| affects |
fetuses
ⓘ
newborns ⓘ |
| affectsSystem |
central nervous system
ⓘ
musculoskeletal system ⓘ visual system ⓘ |
| associatedWith |
Flavivirus infections
ⓘ
Zika virus ⓘ |
| cause |
abnormal cortical development
ⓘ
arthrogryposis ⓘ brain calcifications ⓘ brainstem hypoplasia ⓘ cerebellar hypoplasia ⓘ chorioretinal atrophy ⓘ congenital joint contractures ⓘ developmental delay ⓘ feeding difficulties in infancy ⓘ hearing impairment ⓘ hypertonia ⓘ macular scarring ⓘ ocular abnormalities ⓘ optic nerve hypoplasia ⓘ reduced brain volume ⓘ seizures ⓘ severe microcephaly ⓘ spasticity ⓘ ventriculomegaly ⓘ |
| firstRecognizedAround | 2015 ⓘ |
| firstRecognizedDuring | Zika virus outbreak in Brazil ⓘ |
| hasCause |
intrauterine Zika virus exposure
ⓘ
maternal Zika virus infection during pregnancy ⓘ |
| hasFeature |
excessive crying in infancy
ⓘ
facial disproportion ⓘ irritability in infancy ⓘ neuromotor impairment ⓘ overlapping cranial sutures ⓘ redundant scalp skin ⓘ |
| prevention |
avoiding travel to Zika-affected areas during pregnancy
ⓘ
mosquito bite avoidance in pregnancy ⓘ prevention of Zika virus infection in pregnant women ⓘ |
| recognizedBy |
Centers for Disease Control and Prevention
ⓘ
World Health Organization ⓘ |
| riskFactor |
Zika virus infection in first trimester of pregnancy
ⓘ
Zika virus infection in second trimester of pregnancy ⓘ |
| transmissionRoute |
transplacental transmission
ⓘ
vertical transmission ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: congenital Zika syndrome Description of subject: Congenital Zika syndrome is a pattern of birth defects, including severe microcephaly and brain, eye, and joint abnormalities, that occurs in infants exposed to Zika virus during pregnancy.
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.