Graves disease
E417002
Graves disease is an autoimmune disorder that causes hyperthyroidism, leading to symptoms such as weight loss, heat intolerance, goiter, and characteristic eye manifestations.
All labels observed (3)
| Label | Occurrences |
|---|---|
| Graves disease canonical | 1 |
| Graves’ disease | 1 |
| thyroid-associated ophthalmopathy | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T4160765 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Graves disease Context triple: [Kocher sign, associatedWith, Graves disease]
-
A.
Graves
Graves is a renowned wine-producing subregion on the left bank of Bordeaux, France, famous for its gravelly soils and high-quality red and white wines.
-
B.
Hashimoto
Hashimoto is a city in Wakayama Prefecture, Japan, known as a regional hub between Osaka and the Kii Mountain range.
-
C.
Graves classification
Graves classification is a Bordeaux wine classification system that ranks and recognizes the quality of wines produced in the Graves region of Bordeaux, France.
-
D.
Struma
The Struma is a significant river in the Balkans that flows from western Bulgaria into Greece, ultimately emptying into the Aegean Sea.
-
E.
SLE
SLE is the three-letter ISO 3166-1 alpha-3 country code assigned to Sierra Leone.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Graves disease Target entity description: Graves disease is an autoimmune disorder that causes hyperthyroidism, leading to symptoms such as weight loss, heat intolerance, goiter, and characteristic eye manifestations.
-
A.
Graves
Graves is a renowned wine-producing subregion on the left bank of Bordeaux, France, famous for its gravelly soils and high-quality red and white wines.
-
B.
Hashimoto
Hashimoto is a city in Wakayama Prefecture, Japan, known as a regional hub between Osaka and the Kii Mountain range.
-
C.
Graves classification
Graves classification is a Bordeaux wine classification system that ranks and recognizes the quality of wines produced in the Graves region of Bordeaux, France.
-
D.
Struma
The Struma is a significant river in the Balkans that flows from western Bulgaria into Greece, ultimately emptying into the Aegean Sea.
-
E.
SLE
SLE is a mid-level trim package for GMC vehicles that typically adds upgraded comfort, convenience, and appearance features over the base model.
- F. None of above. chosen
Statements (63)
| Predicate | Object |
|---|---|
| instanceOf |
autoimmune disease
ⓘ
cause of hyperthyroidism ⓘ endocrine disorder ⓘ thyroid disease ⓘ |
| affectsOrgan | thyroid gland ⓘ |
| alsoKnownAs |
Basedow disease
ⓘ
diffuse toxic goiter ⓘ |
| associatedWith |
HLA-B8
ⓘ
HLA-DR3 ⓘ other autoimmune diseases ⓘ |
| canLeadTo |
atrial fibrillation
ⓘ
heart failure ⓘ osteoporosis ⓘ thyroid storm ⓘ |
| hasCause |
autoimmune reaction against thyroid-stimulating hormone receptor
ⓘ
thyroid-stimulating immunoglobulins ⓘ |
| hasComplication |
compressive optic neuropathy
ⓘ
thyroid storm in untreated hyperthyroidism ⓘ vision loss from severe ophthalmopathy ⓘ |
| hasCourse | chronic ⓘ |
| hasDermatologicManifestation |
hyperpigmentation of shins
ⓘ
pretibial myxedema ⓘ warm moist skin ⓘ |
| hasImagingFinding | diffuse increased radioactive iodine uptake ⓘ |
| hasLaboratoryFinding |
elevated free T3
ⓘ
elevated free T4 ⓘ positive TSH receptor antibodies ⓘ positive thyroid-stimulating immunoglobulins ⓘ suppressed TSH ⓘ |
| hasOcularManifestation |
exophthalmos
ⓘ
lid lag ⓘ ophthalmopathy ⓘ periorbital edema ⓘ |
| hasSign |
bruit over thyroid
ⓘ
diffuse goiter ⓘ |
| hasSymptom |
anxiety
ⓘ
diarrhea ⓘ fatigue ⓘ goiter ⓘ heat intolerance ⓘ increased appetite ⓘ insomnia ⓘ oligomenorrhea ⓘ palpitations ⓘ proximal muscle weakness ⓘ tachycardia ⓘ tremor ⓘ weight loss ⓘ |
| moreCommonIn | women ⓘ |
| namedAfter | Robert J. Graves ⓘ |
| riskFactor |
family history of autoimmune disease
ⓘ
female sex ⓘ pregnancy ⓘ smoking ⓘ stress ⓘ |
| treatedWith |
antithyroid drugs
ⓘ
beta blockers ⓘ glucocorticoids for ophthalmopathy ⓘ methimazole ⓘ propylthiouracil ⓘ radioactive iodine ablation ⓘ thyroidectomy ⓘ |
| typicalOnset | adulthood ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Graves disease Description of subject: Graves disease is an autoimmune disorder that causes hyperthyroidism, leading to symptoms such as weight loss, heat intolerance, goiter, and characteristic eye manifestations.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: Graves disease
linked to: Graves disease