The Logic of Chemical Synthesis
E313121
The Logic of Chemical Synthesis is a seminal book by chemist Elias J. Corey that systematically presents the principles and strategies of retrosynthetic analysis for designing complex organic molecule syntheses.
All labels observed (1)
| Label | Occurrences |
|---|---|
| The Logic of Chemical Synthesis canonical | 3 |
How this entity was disambiguated
This entity first appeared as the object of triple T2947667 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: The Logic of Chemical Synthesis Context triple: [Elias J. Corey, notableWork, The Logic of Chemical Synthesis]
-
A.
The Nature of the Chemical Bond
The Nature of the Chemical Bond is a landmark chemistry book by Linus Pauling that systematically explains chemical bonding using quantum mechanics and became one of the most influential scientific texts of the 20th century.
-
B.
Chemical Reviews
Chemical Reviews is a leading peer-reviewed scientific journal that publishes comprehensive and authoritative review articles covering all areas of chemistry.
-
C.
Woodward–Hoffmann rules
The Woodward–Hoffmann rules are fundamental principles in organic chemistry that predict the stereochemistry and feasibility of pericyclic reactions based on orbital symmetry considerations.
-
D.
“Molecular computation of solutions to combinatorial problems”
“Molecular computation of solutions to combinatorial problems” is Leonard Adleman’s pioneering 1994 paper that introduced DNA computing by demonstrating how molecular biology techniques can solve a combinatorial search problem.
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E.
Accounts of Chemical Research
Accounts of Chemical Research is a leading peer-reviewed journal that publishes concise, critical reviews and perspectives on cutting-edge topics across the chemical sciences.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: The Logic of Chemical Synthesis Target entity description: The Logic of Chemical Synthesis is a seminal book by chemist Elias J. Corey that systematically presents the principles and strategies of retrosynthetic analysis for designing complex organic molecule syntheses.
-
A.
The Nature of the Chemical Bond
The Nature of the Chemical Bond is a landmark chemistry book by Linus Pauling that systematically explains chemical bonding using quantum mechanics and became one of the most influential scientific texts of the 20th century.
-
B.
Chemical Reviews
Chemical Reviews is a leading peer-reviewed scientific journal that publishes comprehensive and authoritative review articles covering all areas of chemistry.
-
C.
Woodward–Hoffmann rules
The Woodward–Hoffmann rules are fundamental principles in organic chemistry that predict the stereochemistry and feasibility of pericyclic reactions based on orbital symmetry considerations.
-
D.
“Molecular computation of solutions to combinatorial problems”
“Molecular computation of solutions to combinatorial problems” is Leonard Adleman’s pioneering 1994 paper that introduced DNA computing by demonstrating how molecular biology techniques can solve a combinatorial search problem.
-
E.
Accounts of Chemical Research
Accounts of Chemical Research is a leading peer-reviewed journal that publishes concise, critical reviews and perspectives on cutting-edge topics across the chemical sciences.
- F. None of above. chosen
Statements (46)
| Predicate | Object |
|---|---|
| instanceOf |
book
ⓘ
chemistry book ⓘ organic chemistry book ⓘ scientific monograph ⓘ |
| author | Elias J. Corey ⓘ |
| contribution |
formalization of retrosynthetic analysis as a planning tool
ⓘ
framework for teaching synthetic strategy ⓘ |
| describes |
criteria for evaluating synthetic routes
ⓘ
general strategies for bond disconnections ⓘ strategies for complexity building in organic molecules ⓘ systematic methods for planning multistep organic syntheses ⓘ use of idealized synthons in planning routes ⓘ |
| emphasizes | generalizable synthetic strategies over specific named reactions ⓘ |
| field |
organic chemistry
ⓘ
retrosynthetic analysis ⓘ synthetic organic chemistry ⓘ |
| hasAudience |
advanced students of organic chemistry
ⓘ
professional synthetic chemists ⓘ |
| hasConcept |
convergent synthesis design
ⓘ
disconnection approach ⓘ functional group interconversion ⓘ functional group strategy ⓘ linear versus convergent routes ⓘ protecting group strategy ⓘ retron analysis ⓘ stereochemical strategy in synthesis ⓘ strategic bonds ⓘ synthetic equivalents ⓘ synthons ⓘ topological strategy ⓘ transform-based planning ⓘ transform-based synthetic logic ⓘ |
| hasPerspective | retrosynthetic (backward) analysis from target to starting materials ⓘ |
| influenced |
computer-assisted synthesis planning methods
ⓘ
teaching of organic synthesis worldwide ⓘ |
| influencedBy | Elias J. Corey’s work on retrosynthetic analysis ⓘ |
| language | English ⓘ |
| mainSubject |
design of complex organic molecule syntheses
ⓘ
strategy in organic synthesis ⓘ |
| notableFor |
influence on modern synthetic planning in organic chemistry
ⓘ
systematic presentation of principles of retrosynthetic analysis ⓘ |
| relatedTo | Nobel Prize in Chemistry 1990 awarded to Elias J. Corey ⓘ |
| topic |
optimization of synthetic routes
ⓘ
planning of complex natural product syntheses ⓘ strategic use of key transformations in synthesis ⓘ |
| usedAs | reference text in graduate organic synthesis courses ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: The Logic of Chemical Synthesis Description of subject: The Logic of Chemical Synthesis is a seminal book by chemist Elias J. Corey that systematically presents the principles and strategies of retrosynthetic analysis for designing complex organic molecule syntheses.
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.