Crohn’s disease

E242405

Crohn’s disease is a chronic inflammatory bowel disease that causes inflammation of the digestive tract, leading to symptoms such as abdominal pain, diarrhea, weight loss, and fatigue.

All labels observed (3)

How this entity was disambiguated

Statements (65)

Predicate Object
instanceOf autoimmune-related disorder ⓘ
chronic disease ⓘ
gastrointestinal disease ⓘ
inflammatory bowel disease ⓘ
affectsOrgan colon ⓘ
ileum ⓘ
large intestine ⓘ
small intestine ⓘ
affectsRegion any part of the gastrointestinal tract from mouth to anus ⓘ
affectsSystem digestive system ⓘ
associatedWith NOD2 gene variants ⓘ
immune dysregulation ⓘ
commonSymptom abdominal pain ⓘ
chronic diarrhea ⓘ
fatigue ⓘ
fever ⓘ
rectal bleeding ⓘ
reduced appetite ⓘ
weight loss ⓘ
course chronic ⓘ
relapsing-remitting ⓘ
diagnosticMethod CT enterography ⓘ
MR enterography ⓘ
blood tests for inflammation markers ⓘ
colonoscopy with biopsy ⓘ
endoscopy ⓘ
stool tests ⓘ
epidemiology more common in North America and Europe ⓘ
etiology multifactorial ⓘ
extraIntestinalManifestation arthritis ⓘ
erythema nodosum ⓘ
primary sclerosing cholangitis ⓘ
uveitis ⓘ
firstDescribed 1932 ⓘ
management dietary modification ⓘ
smoking cessation ⓘ
medicalSpecialty gastroenterology ⓘ
immunology ⓘ
namedAfter Burrill Bernard Crohn ⓘ
pathologyFeature cobblestone appearance of mucosa ⓘ
noncaseating granulomas ⓘ
skip lesions ⓘ
transmural inflammation ⓘ
possibleComplication abscesses ⓘ
bowel obstruction ⓘ
colon cancer ⓘ
fistulas ⓘ
intestinal strictures ⓘ
malnutrition ⓘ
perianal disease ⓘ
prognosis often requires lifelong management ⓘ
variable ⓘ
riskFactor Ashkenazi Jewish ancestry ⓘ
Western diet ⓘ
cigarette smoking ⓘ
family history of inflammatory bowel disease ⓘ
urban living ⓘ
treatment TNF inhibitors ⓘ
aminosalicylates ⓘ
biologic therapies ⓘ
corticosteroids ⓘ
immunomodulators ⓘ
surgical resection of affected bowel segments ⓘ
typicalOnset adolescence ⓘ
early adulthood ⓘ

How these facts were elicited

Referenced by (11)

Full triples — surface form annotated when it differs from this entity's canonical label.

Remicade → isUsedFor → Crohn’s disease ⓘ
Stelara → isUsedFor → Crohn’s disease ⓘ
David Garrard → diagnosedWith → Crohn's disease ⓘ
linked to: Crohn’s disease
Anastacia → hasHealthCondition → Crohn’s disease ⓘ
Mike McCready → hasMedicalCondition → Crohn's disease ⓘ
linked to: Crohn’s disease
Peter Michael Davidson → hasMedicalCondition → Crohn's disease ⓘ
linked to: Crohn’s disease
Burrill Bernard Crohn → knownFor → Crohn's disease ⓘ
linked to: Crohn’s disease
Burrill Bernard Crohn → authorOf → “Regional ileitis: a pathologic and clinical entity” ⓘ
linked to: Crohn’s disease
Burrill Bernard Crohn → hasEponym → Crohn's disease ⓘ
linked to: Crohn’s disease
tumor necrosis factor alpha → associatedWithDisease → Crohn's disease ⓘ
linked to: Crohn’s disease
infliximab-qbtx → usedFor → Crohn’s disease ⓘ